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Regulation of steady-state neutrophil homeostasis by
macrophages
by Claire Gordy, Heather Pua, Gregory D. Sempowski, and You-Wen He
Blood
Volume 117(2):618-629
January 13, 2011
©2011 by American Society of Hematology
c-FLIP is required for macrophage survival.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
Loss of macrophages in c-FLIPf/f LysM-Cre mice.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
Bone marrow stromal macrophages are lost and hematopoiesis is altered in c-FLIPf/f LysM-Cre
mice.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
c-FLIPf/f LysM-Cre mice lack marginal zone macrophages and have splenomegaly and splenic
extramedullary hematopoiesis.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
Neutrophilia in c-FLIPf/f LysM-Cre mice is G-CSF–dependent.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
Neutrophil clearance is delayed in c-FLIPf/f LysM-Cre mice.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
Neutrophilia, splenomegaly, decreased body size, and increased G-CSF production are
secondary to the loss of macrophages in c-FLIPf/f LysM-Cre mice.
Claire Gordy et al. Blood 2011;117:618-629
©2011 by American Society of Hematology
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