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Regulation of steady-state neutrophil homeostasis by macrophages by Claire Gordy, Heather Pua, Gregory D. Sempowski, and You-Wen He Blood Volume 117(2):618-629 January 13, 2011 ©2011 by American Society of Hematology c-FLIP is required for macrophage survival. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology Loss of macrophages in c-FLIPf/f LysM-Cre mice. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology Bone marrow stromal macrophages are lost and hematopoiesis is altered in c-FLIPf/f LysM-Cre mice. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology c-FLIPf/f LysM-Cre mice lack marginal zone macrophages and have splenomegaly and splenic extramedullary hematopoiesis. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology Neutrophilia in c-FLIPf/f LysM-Cre mice is G-CSF–dependent. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology Neutrophil clearance is delayed in c-FLIPf/f LysM-Cre mice. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology Neutrophilia, splenomegaly, decreased body size, and increased G-CSF production are secondary to the loss of macrophages in c-FLIPf/f LysM-Cre mice. Claire Gordy et al. Blood 2011;117:618-629 ©2011 by American Society of Hematology
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