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Recent insights into the mechanisms of myeloid
leukemogenesis in Down syndrome
by Sandeep Gurbuxani, Paresh Vyas, and John D. Crispino
Blood
Volume 103(2):399-406
January 15, 2004
©2004 by American Society of Hematology
A subset of genes located on chromosome 21.
Sandeep Gurbuxani et al. Blood 2004;103:399-406
©2004 by American Society of Hematology
GATA factors in hematopoiesis.
Sandeep Gurbuxani et al. Blood 2004;103:399-406
©2004 by American Society of Hematology
GATA1 is mutated in TMD and AMKL. Positions of the various alterations in GATA1.
Sandeep Gurbuxani et al. Blood 2004;103:399-406
©2004 by American Society of Hematology
Model for the progression of TMD and AMKL in DS. Trisomy 21 likely represents the initiating
event in leukemogenesis of DS because it occurs very early in embryogenesis.
Sandeep Gurbuxani et al. Blood 2004;103:399-406
©2004 by American Society of Hematology
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