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Differential Incorporation of Ara-C, Gemcitabine, and Fludarabine Into Replicating and Repairing DNA in Proliferating Human Leukemia Cells by Hiromichi Iwasaki, Peng Huang, Michael J. Keating, and William Plunkett Blood Volume 90(1):270-278 July 1, 1997 ©1997 by American Society of Hematology Incorporation of [3H]ara-C, [3H]dFdC, and [3H]F-ara-A into DNA. Approximately 1.5 × 107 exponentially growing CCRF-CEM cells suspended in 50 mL culture medium were labeled with: (A) [3H]dThd (0.2 μCi/mL), (B) [5-3H] dCyd (0.2 μCi/mL), (C) 0.6 nmol/L [3H]ara... Hiromichi Iwasaki et al. Blood 1997;90:270-278 ©1997 by American Society of Hematology Effect of hydroxyurea on [3H]ara-C incorporation into DNA. Exponentially growing CCRF-CEM cells were treated without (○) or with 0.2 mmol/L hydroxyurea (•) 15 minutes before adding 0.6 nmol/L [3H]ara-C (1.5 × 10−2 μCi/mL) in the presence of 1.0 μmol/L BrdUr... Hiromichi Iwasaki et al. Blood 1997;90:270-278 ©1997 by American Society of Hematology Changes of [3H]ara-C incorporation into DNA by dFdC. Hiromichi Iwasaki et al. Blood 1997;90:270-278 ©1997 by American Society of Hematology Effects of UV irradiation on [3H]ara-C incorporation into DNA. Exponentially growing CCRF-CEM cells were treated without (○), or with 10 J/m2 UV light (•). Hiromichi Iwasaki et al. Blood 1997;90:270-278 ©1997 by American Society of Hematology Effect of UV irradiation on the incorporation of dFdC or F-ara-A. Hiromichi Iwasaki et al. Blood 1997;90:270-278 ©1997 by American Society of Hematology
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