Download Brain control thyroid RL 2010

BRAIN CONTROL OF THE THYROID 2010
Theme: Signalling between the brain and the periphery; Signalling in Health and Disease/Neuroscience
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If you only read one article read:
Chiamolera & Wondisford (2009) Minireview: TRH and the thyroid hormone feedback mechanism.
Endocrinology 150:1091-1096
Central and Pituitary regulation of the thyroid
Brabant et al (1990) J Clin Endocr Metab 70:403-409 Circadian and pulsatile TSH secretion
Brabant et al (1991) J Clin Endocr Metab 72:145-150 TRH controls TSH pulses
Zhao et al (1992) Endocrinology 130:3529-3536 TRH receptor cloned; effects TRH, glucocorticoids
Above are the historic first articles characterising the HPT axis
Mihaly et al (2000) J Clin Endocrinol Metab 85:2596-2603 TRH neurons innervated by NPY, AGRP
Human brain study showing innervation of TRH neurons by neurons involved in feeding
**Boelen et al (2008) Fasting induced changes in HPT axis. Thyroid, 18(2): 123-129
Thorough review of the evidence for resetting of HPT axis regulation in caloric deprivation
Feedback by T3 and T4
Kakucska et al (1992) Endocrinology 130:2845-50 Regulation of TRH involves T3 and T4
Prummel et al (2004) Ultra short feedback control of TSH secretion. Thyroid 10:825
Fekete (2007) Negative feedback regulation of TRH neurons, role of neuronal afferents and Type 2
Deiodinase. Frontiers Neuroendocrinology 28:97-114
A thorough review of regulation of the TRH neuron – more than you need but an invaluable source of
information.
Fliers et al (2006) Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and
pituitary gland. Mol Cell Endocrinol 251:1-8
Thyroid gland actions of TSH
Corvilain et al (1994) J Clin Endocr Metab 79:152-159 cAMP/PI-Ca cascades mediate TSH action
Postiglione et al (2002) TSH receptor role in thyroid gland development. PNAS 99:15462-15467
Transgenic mouse studies
Abel et al (1999) J Clin Invest 103:271-279. Knockout of TR in pituitary
Shibusawa et al (2003) Thyroid hormone action in the absence of DNA binding. J Clin Invest 112:588.
Dupre S et al (2004) Endocrinology 145:2337-2345 Both thyroid hormone receptor isoforms reg TRH
Rescue of specific TRbeta isoforms in TRbeta KO mice shows both regulate TRH
Nikrodhanond et al (2006) Dominant role of TRH in the HPT axis. J Biol Chem 281:5000-5007
Compares TRH KO, TRbeta KO and double TR KO
Galton VA et al (2007) Thyroid hormone homeostasis in Deiodinase 2 KO. Endocrinology 148: 3080-8
Trajkovic et al (2007) Abnormal thyroid metabolism in MCR8 KO mice. J Clin Invest. 117:627-35
LINKS TO OTHER LECTURES/THEMES
Non-genomic, rapid actions of thyroid hormones
Incerpi (2005) Thyroid hormones: rapid reply by surface delivery only. Endocrinology 146:2861-2863
(Commentary on article Bergh et al Endocrinology 146:2864)
Membrane transporter proteins: Thyroid hormone transport by MCT8
** Friesema et al (2006) Mutations in MCT8 thyroid transporter and disease. Nature Clin Practice 2:512523 or slightly more recent Visser WE et al (2007)Thyroid hormone transport in and out of cells. Trends
Endocrin Metabolism 19:50-56
This group have written many reviews of their discovery of MCT8 and thyroid hormone transport, any are
good reads
Circadian rhythms
Ono et al (2008) Involvement of thyrotropin (TSH) in photoperiodic signal transduction in mice. PNAS
105:18238-18242
Yang et al (2006) Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801
Appetite/obesity
Kong et al (2004) Triiodothyronine stimulates food intake via the hypothalamic ventromedial nucleus
independent of changes in energy expenditure endocrinology 145: 5252-5258
Reinehr (2010) Obesity and thyroid function. Mol Cell Endocrinol 316: 165-71
Stress and glucocorticoids
John CD, Christian HC, Morris JF, Flower RJ, Buckingham JC (2003). Kinase-dependent regulation of
the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin I peptides. J
Neuroendocrinology 15:946-957
Reproduction
Trokoudes et al (2006) Infertility and thyroid disorders. Current Opin Obstetrics and Gynecology 18:446
Metabolism
-see Thyroid Lecture in Growth and Metabolism Theme (Signalling)