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Strategic Approaches to Unraveling Genetic Causes of Cardiovascular Diseases by A.J. Marian, and John Belmont Circulation Research Volume 108(10):1252-1269 May 13, 2011 Copyright © American Heart Association, Inc. All rights reserved. Genomic and genetic determinants of phenotype. A.J. Marian, and John Belmont Circ Res. 2011;108:12521269 Copyright © American Heart Association, Inc. All rights reserved. Gradients of disease prevalence, minor allele frequencies, and effect sizes. A.J. Marian, and John Belmont Circ Res. 2011;108:12521269 Copyright © American Heart Association, Inc. All rights reserved. Relationship between effect sizes of DNA sequence variants and proximity of the phenotype. A.J. Marian, and John Belmont Circ Res. 2011;108:12521269 Copyright © American Heart Association, Inc. All rights reserved. Detection of single nucleotide variant by whole-exome sequencing. A.J. Marian, and John Belmont Circ Res. 2011;108:12521269 Copyright © American Heart Association, Inc. All rights reserved. Clinical implications of DNA sequence variants (DSV). A.J. Marian, and John Belmont Circ Res. 2011;108:12521269 Copyright © American Heart Association, Inc. All rights reserved.