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CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells by Aurelie Thedrez, Claudia de Lalla, Sophie Allain, Luca Zaccagnino, Stephane Sidobre, Claudio Garavaglia, Giovanna Borsellino, Paolo Dellabona, Marc Bonneville, Emmanuel Scotet, and Giulia Casorati Blood Volume 110(1):251-258 July 1, 2007 ©2007 by American Society of Hematology Blocking CD4 inhibits antigen-specific activation of CD4 + iNKT cell clones. Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology The CD4-CD1d interaction is critical for the antigen-specific activation of CD4 + iNKT cells clones. Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology The CD4-CD1d interaction is critical for the antigen-specific activation of CD4 + invTCR transfectants. Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology DN and CD4 + NKT cell clones expressing identical TCR are differentially activated after αGalCer/CD1d activation. Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology Differential binding of α-GalCer–loaded CD1d tetramers on CD4 + and DN human iNKT cell clones expressing identical TCR. (A) iNKT cell clones 20.22 (open symbols) and 20.49 (closed symbols) were incubated with increasing concentrations of α-GalCer–loaded CD1... Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology Peptides corresponding to the MHC class II and the putative CD1 regions binding to CD4 affect effector responses and TCR engagement of CD4 + iNKT cells. Aurelie Thedrez et al. Blood 2007;110:251-258 ©2007 by American Society of Hematology
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