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Molecular characterization of in-frame and out-of-frame
alternative splicings in coagulation factor XI pre-mRNA
by Rosanna Asselta, Valeria Rimoldi, Ilaria Guella, Giulia Soldà, Raimondo De
Cristofaro, Flora Peyvandi, and Stefano Duga
Blood
Volume 115(10):2065-2072
March 11, 2010
©2010 by American Society of Hematology
Global screening of the F11 splicing pattern.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
Characterization of F11 alternatively spliced transcripts.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
Impact of pharmacologic inhibition of the NMD pathway on F11 splicing and quantification of the
alternative transcript lacking exons 6+7.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
Metabolic labeling of wild-type and Δ6/7 mutant recombinant FXI in transiently transfected COS1 cells.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
Quantitation by ELISA and measurement of the specific activity of wild-type and Δ6/7
recombinant FXIs. pcDNA3/FXI, or pcDNA3/FXI-Δ6/7, or equimolar amounts of both plasmids
(heterozygous condition) were transiently transfected in COS-1 cells.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
Immunoprecipitation of FXI Δ6/7 isoform from normal plasma.
Rosanna Asselta et al. Blood 2010;115:2065-2072
©2010 by American Society of Hematology
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