Download Powerpoint - Blood Journal

Myelodysplastic syndrome is not merely “preleukemia”
by Maher Albitar, Taghi Manshouri, Yu Shen, Diane Liu, Miloslav Beran, Hagop M.
Kantarjian, Anna Rogers, Iman Jilani, Chung Wu Lin, Sherry Pierce, Emil J.
Freireich, and Elihu H. Estey
Blood
Volume 100(3):791-798
August 1, 2002
©2002 by American Society of Hematology
Distribution of percentage of bone marrow blasts in patients with AML and MDS.There is no
bimodal distribution for the percentage of blasts.
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Increased apoptosis in MDS as measured by annexin V.(A) Representative example of annexin V
analysis showing greater annexin V level in a bone marrow sample in a patient with MDS than in
a patient with AML. (B) Box plot showing significantly greater levels ...
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Increased apoptosis in MDS as measured by mitochondrial potential.(A) Representative example
of mitochondrial potential analysis showing greater apoptotic activity in bone marrow of a
patient with MDS (green, detected on FL2, instead of orange, detected on ...
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Box plot showing significantly higher caspase 3 activity in patients with MDS than in those with
AML.
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Increased proliferation in MDS.(A) Representative example demonstrating greater BrdU
incorporation in CD34+cells of a patient with MDS than in those of a patient with AML. (B) Box
plot showing significantly greater BrdU incorporation in cells of patients wi...
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Representative example demonstrating clonality in various subpopulations of cells in patients
with MDS.(A) LOH (D5S471).
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology
Scatter plot showing increased numbers of apoptotic CD34+ cells in AML and MDS patients
when the percentage of total CD34+ cells is low.We gated here on all cells in the aspirate
samples rather than on mononuclear cells.
Maher Albitar et al. Blood 2002;100:791-798
©2002 by American Society of Hematology