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Transcript 
IL-21 in the bone marrow microenvironment contributes to
IgM secretion and proliferation of malignant cells in
Waldenstrom macroglobulinemia
by Lucy S. Hodge, Steve C. Ziesmer, Zhi Zhang Yang, Frank J. Secreto, Morie A.
Gertz, Anne J. Novak, and Stephen M. Ansell
Blood
Volume 120(18):3774-3782
November 1, 2012
©2012 by American Society of Hematology
IL-21, IL-21R, and common γ chain receptor expression on WM cells.
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
IL-21 in the WM bone marrow microenvironment is derived from activated T cells.
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
Biologic effects of IL-21 on the WM cell line, MWCL-1.
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
Biologic effects of IL-21 on CD19+CD138+ cells obtained from patients with WM (n = 5, WM14,
WM15, WM25-WM27).
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
IL-21 mediates its biologic effects through activation of STAT3.
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
IL-21 regulates gene and protein expression in WM. (A) qRT-PCR analysis of transcription
factors involved in B-cell differentiation.
Lucy S. Hodge et al. Blood 2012;120:3774-3782
©2012 by American Society of Hematology
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