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Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation by Rossana Trotta, Robin Parihar, Jianhua Yu, Brian Becknell, Jeffrey Allard, Jing Wen, Wei Ding, Hsiaoyin Mao, Susheela Tridandapani, William E. Carson, and Michael A. Caligiuri Blood Volume 105(8):3011-3018 April 15, 2005 ©2005 by American Society of Hematology SHIP1 expression in NK cells. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology Overexpression of SHIP1 blunts monokine-activated IFN-γ production in NK92 and primary human NK cells. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology Quantification of IFN-γ gene and protein expression in NK92 cells overexpressing SHIP1, or quantification of SHIP1 protein in NK92 cells, each following stimulation or costimulation by monokines. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology Effect of the PI-3K inhibitor LY294002 on IFN-γ production by monokine-activated primary human NK cells. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology Effect of catalytic mutant SHIP1 (D675A) overexpression on IFN-γ production induced by monokine costimulation of NK cells. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology Assessment of NK cell IFN-γ production in WT and Ship1–/– mice following monokine stimulation. Rossana Trotta et al. Blood 2005;105:3011-3018 ©2005 by American Society of Hematology
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