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Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7 by Lior Zangi, Yael Zlotnikov Klionsky, Liran Yarimi, Esther Bachar-Lustig, Yaki Eidelstein, Elias Shezen, David Hagin, Yumi Ito, Toshiyuki Takai, Shlomit ReichZeliger, Assaf Lask, Oren Milstein, Steffen Jung, Vera Shinder, and Yair Reisner Blood Volume 120(8):1647-1657 August 23, 2012 ©2012 by American Society of Hematology Cell phenotype changes upon differentiation of LSKs into imDCs. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology Mechanisms of CD4+ and CD8+ T-cell deletion by imDCs. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology MHC-dependent killing of CD8+ T cells by imDCs is predominantly mediated by perforin and not by the NO system. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology MHC-dependent inhibition of alloreactive CD8+ T cells in MLR: perforin-mediated killing is associated with granzyme A activity. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology Granules of perforin and granzyme A are located near the cell membrane of the imDCs and are polarized toward the alloreactive CD8+ T-cell contact area. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology MHC-dependent perforin/granzyme A–mediated killing of cognate CD8+ T cells in MLR is associated with triggering of TLR7/8 and TREM-1. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology Proposed 4-stage model for mechanism of T-cell suppression by imDCs. Lior Zangi et al. Blood 2012;120:1647-1657 ©2012 by American Society of Hematology
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