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Structure and function of factor XI by Jonas Emsley, Paul A. McEwan, and David Gailani Blood Volume 115(13):2569-2577 April 1, 2010 ©2010 by American Society of Hematology Plasma coagulation protease reactions. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology Human FXI apple domains. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology The structure of zymogen FXI. Topology diagram of dimeric FXI viewed from 2 perspectives rotated 90 degrees. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology FXI-binding site for HK. (A) The relative positions of Gly104 and Gly155 in the A2 domain are shown. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology FXI activation. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology The FXIa protease domain. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology FIX activation. Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology Platelet-binding site on FXI. The locations of 2 residues (Ser248 and Arg250 in black), that probably form a GPIb platelet-binding site on the FXI A3 domain (orange), are shown relative to residues that form the heparin-binding site (Ly252, Lys253, and Lys2... Jonas Emsley et al. Blood 2010;115:2569-2577 ©2010 by American Society of Hematology
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