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Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients by Cirino Botta, Domenico Ciliberto, Marco Rossi, Nicoletta Staropoli, Maria Cucè, Teresa Galeano, Pierosandro Tagliaferri, and Pierfrancesco Tassone BloodAdv Volume 1(7):455-466 February 28, 2017 © 2017 by The American Society of Hematology Cirino Botta et al. Blood Adv 2017;1:455-466 © 2017 by The American Society of Hematology PRISMA flowchart for study selection and review. Cirino Botta et al. Blood Adv 2017;1:455-466 © 2017 by The American Society of Hematology Forest plots of comparisons between experimental treatments and standard treatments in terms of PFS and OS. Bortezomib (BORT) with or without dexamethasone represents the standard treatment (ST) in (A) PFS and (C) OS; IMiDs represent the standard treatment in (B) PFS and (D) OS. Subgroups have been created according to drug classes. Cirino Botta et al. Blood Adv 2017;1:455-466 © 2017 by The American Society of Hematology Network of the comparisons and comparative efficacy and tolerance results. Cirino Botta et al. Blood Adv 2017;1:455-466 © 2017 by The American Society of Hematology Ranking of treatments based on NMA results. Cirino Botta et al. Blood Adv 2017;1:455-466 © 2017 by The American Society of Hematology