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Cells: The Basics 1. A prokaryote is an organism made up of prokaryotic cells. A prokaryotic cell does not have a nucleus. Prokaryotes arose more than 2.5 billion years ago. 2. Prokaryotes are very small cells with simple structure. They have DNA, cytoplasm, and ribosomes. 3. A prokaryotic cell has a cell membrane, cell wall and some have a sticky outer surface called a capsule. 4. A eukaryote is an organism made up of one or more eukaryotic cells. Eukaryotes arose about 1.5 billion years ago. 5. Prokaryote – capsule and cell wall 6.Eukaryote – nucleus and many membrane-bound organelles 7. Both – cell membrane, DNA, cytoplasm, ribosomes 8. Multicellular organisms arose from both prokaryotic and eukaryotic cells.