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Beta-agonists modulate T-cell functions via direct actions
on type 1 and type 2 cells
by Matthew J. Loza, Susan Foster, Stephen P. Peters, and Raymond B. Penn
Blood
Volume 107(5):2052-2060
March 1, 2006
©2006 by American Society of Hematology
Multiple agents promote VASP phosphorylation in a PKA-dependent manner.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
Modulation of PKA activity by PKC. (A) Freshly isolated PBLs were stimulated as described in
Figure 1B, using PHA (4 μg/mL) and PMA (5 nM) as the stimuli, then analyzed for VASP-phosphoSer157 by flow cytometry.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
β-agonist-induced PKA activity in type 2 T cells.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
Inhibition of CD25 induction in type 2 T cells by β-agonist.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
Modulation of cytokine production by β-agonist and PGE2.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
Regulation of p42/p44, p38, and NF-κB phosphorylation in T cells.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
MAPK dependence for cytokine production.
Matthew J. Loza et al. Blood 2006;107:2052-2060
©2006 by American Society of Hematology
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