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Midsternal line 2ndFigure rib 18.1a Location of the Sternum heart in the mediastinum. Diaphragm Point of maximal intensity (PMI) Superior vena cava Aorta Parietal pleura (cut) Figure 18.1c Location of the Pulmonary Left lung trunk heart in the mediastinum. Pericardium (cut) Diaphragm (c) Apex of heart Pulmonary trunk Fibrous pericardium Parietal layer of serous pericardium Pericardial cavity Epicardium (visceral layer Heart of serous pericardium) wall Figure 18.2 The pericardial layers and layers of the heart wall. Myocardium Pericardium Myocardium Endocardium Heart chamber Brachiocephalic trunk Superior vena cava Right pulmonary artery Left common carotid artery Left subclavian artery Aortic arch Ligamentum arteriosum Left pulmonary artery Ascending aorta Pulmonary trunk Left pulmonary veins Right pulmonary veins Auricle of left atrium Figure 18.4b Gross anatomy of the heart. Right atrium Circumflex artery Right coronary artery (in coronary sulcus) Left coronary artery (in coronary sulcus) Anterior cardiac vein Left ventricle Right ventricle Right marginal artery Small cardiac vein Inferior vena cava (b) Anterior view Great cardiac vein Anterior interventricular artery (in anterior interventricular sulcus) Apex Aorta Left pulmonary artery Superior vena cava Left pulmonary veins Auricle of left atrium Right pulmonary veins Right pulmonary artery Right atrium Figure 18.4d Gross anatomy Left atrium Inferior vena cava of the heart. Coronary sinus Great cardiac vein Posterior vein of left ventricle Left ventricle Apex Right coronary artery (in coronary sulcus) Posterior interventricular artery (in posterior interventricular sulcus) Middle cardiac vein Right ventricle (d) Posterior surface view Aorta Superior vena cava Right pulmonary artery Pulmonary trunk Left pulmonary artery Left atrium Left pulmonary veins Right atrium Mitral (bicuspid) Figure 18.4e Gross anatomy Right pulmonary valve veins Fossa ovalis of the heart. Aortic valve Pectinate muscles Tricuspid valve Right ventricle Chordae tendineae Trabeculae carneae Inferior vena cava (e) Frontal section Pulmonary valve Left ventricle Papillary muscle Interventricular septum Epicardium Myocardium Endocardium Pulmonary Circuit Capillary beds of lungs where gas exchange occurs Pulmonary veins Aorta and branches Pulmonary arteries Figure 18.5 The systemic Left atrium and pulmonary circuits. Left ventricle Right atrium Venae cavae Right ventricle Oxygen-rich, CO2-poor blood Oxygen-poor, CO2-rich blood Heart Systemic Circuit Capillary beds of all body tissues where gas exchange occurs Aorta Pulmonary trunk Left atrium Superior vena cava Anastomosis (junction of vessels) Right atrium Figure 18.7 Coronary circulation. Left coronary artery Circumflex artery Superior vena cava Anterior cardiac veins Right coronary artery Left ventricle Right ventricle Anterior Right interventricular marginal artery Posterior artery interventricular artery (a) The major coronary arteries Great cardiac vein Coronary sinus Small cardiac vein (b) The major cardiac veins Middle cardiac vein Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Myocardium Figure 18.8a HeartTricuspid valves. (right atrioventricular) valve Mitral (left atrioventricular) valve Aortic valve Fibrous skeleton (a) Pulmonary valve Anterior Pulmonary valve Aortic valve Area of cutaway Mitral valve Tricuspid valve Figure 18.8c Heart valves. Chordae tendineae attached to tricuspid valve flap (c) Papillary muscle 1 Blood returning to the heart fills atria, putting pressure against atrioventricular valves; atrioventricular valves are forced open. 2 As ventricles fill, atrioventricular valve flaps hang limply into ventricles. Direction of blood flow 3 Atria contract, forcing Chordae tendineae Atrium Cusp of atrioventricular valve (open) Figure 18.9 The atrioventricular valves. additional blood into ventricles. Ventricle Papillary muscle (a) AV valves open; atrial pressure greater than ventricular pressure Atrium 1 Ventricles contract, forcing blood against atrioventricular valve cusps. Cusps of atrioventricular valve (closed) 2 Atrioventricular valves close. 3 Papillary muscles contract and chordae tendineae tighten, preventing valve flaps from everting into atria. (b) AV valves closed; atrial pressure less than ventricular pressure Blood in ventricle Aorta Pulmonary trunk As ventricles contract and intraventricular pressure rises, blood is pushed up against semilunar valves, forcing them open. (a) Semilunar valves open Figure 18.10 The semilunar valves. As ventricles relax and intraventricular pressure falls, blood flows back from arteries, filling the cusps of semilunar valves and forcing them to close. (b) Semilunar valves closed Aorta Pulmonary trunk As ventricles contract and intraventricular pressure rises, blood is pushed up against semilunar valves, forcing them open. (a) Semilunar valves open Figure 18.10a The semilunar valves. As ventricles relax and intraventricular pressure falls, blood flows back from arteries, filling the cusps of semilunar valves and forcing them to close. Figure 18.10b The semilunar valves. (b) Semilunar valves closed Superior vena cava Right atrium 1 The sinoatrial (SA) node (pacemaker) generates impulses. Internodal pathway Pacemaker potential SA node Figure 18.14 Cardiac intrinsic conduction system and action potential succession during one heartbeat. 2 The impulses Left atrium pause (0.1 s) at the atrioventricular (AV) node. 3 The atrioventricular (AV) bundle connects the atria to the ventricles. 4 The bundle branches conduct the impulses through the interventricular septum. 5 The Purkinje fibers depolarize the contractile cells of both ventricles. (a) Anatomy of the intrinsic conduction system showing the sequence of electrical excitation Atrial muscle Purkinje fibers AV node Interventricular septum Ventricular muscle Pacemaker potential Plateau Milliseconds (b) Comparison of action potential shape at various locations Superior vena cava Right atrium 1 The sinoatrial (SA) node (pacemaker) generates impulses. Internodal pathway 2 The impulses Left atrium pause (0.1 s) at the atrioventricular (AV) node. 3 The atrioventricular (AV) bundle connects the atria to the ventricles. Purkinje fibers 4 The bundle branches conduct the impulses through the interventricular septum. 5 The Purkinje fibers Interventricular septum depolarize the contractile cells of both ventricles. (a) Anatomy of the intrinsic conduction system showing the sequence of electrical excitation Nucleus (a) Intercalated discs Cardiac muscle cell Gap junctions Desmosomes Figure 18.11 Microscopic anatomy of cardiac muscle. Cardiac muscle cell Intercalated disc Mitochondrion Nucleus Mitochondrion T tubule Sarcoplasmic reticulum (b) Z disc Nucleus Sarcolemma I band A band I band QRS complex Sinoatrial node Ventricular depolarization Ventricular repolarization Figure 18.16 An Atrial depolarization electrocardiogram tracing (lead I). Atrioventricular node P-Q Interval S-T Segment Q-T Interval SA node Depolarization R Repolarization R T P T P Q S 1 Atrial depolarization, initiated by the SA node, causes the P wave. R AV node Q S 4 Ventricular depolarization is complete. R T P T P Q S 2 With atrial depolarization complete, the impulse is delayed at the AV node. R Q S 5 Ventricular repolarization begins at apex, causing the T wave. R T P T P Q S 3 Ventricular depolarization begins at apex, causing the QRS complex. Atrial repolarization occurs. Q S 6 Ventricular repolarization is complete.