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Functional Expression of Fas (CD95) in Acute Myeloid
Leukemia Cells in the Context of CD34 and CD38
Expression: Possible Correlation With Sensitivity to
Chemotherapy
by Narikazu Iijima, Koichi Miyamura, Toshihide Itou, Mitsune Tanimoto, Ryou Sobue,
and Hidehiko Saito
Blood
Volume 90(12):4901-4909
December 15, 1997
©1997 by American Society of Hematology
Fas expression on leukemia cells from 64 patients with AML by flow cytometric analysis.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Induction of Fas expression on leukemia cells after the incubation with interferon γ and
interferon α at the concentration of 40, 200, and 1,000 IU/mL.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Fas and CD34 expression on cells from 64 patients with AML. The left half shows the percentage
of CD34+ cell and the right half shows the percentage of Fas+ cell corresponding with the left
column.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Normal BM MNC (A-D) and representative data of 16 AML cells (E-T) of two-color flow cytometric
analysis of Fas expression and CD34 expression.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Representative data of three-color analysis of three AML cells.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Three-color analysis of 13 leukemia samples.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Representative results of three colorimetric DNA fragmentation assays.
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
Fas expression and the induction of apoptosis is shown. Δ-apoptosis (Δ200 and Δ1000; %
increase of apoptosis after the incubation with anti-Fas MoAb at different concentration) is the
percentage of increased number of apoptotic cells by colorimetric DNA fra...
Narikazu Iijima et al. Blood 1997;90:4901-4909
©1997 by American Society of Hematology
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