Download BIOL 4260 Human Evolu.onary Anatomy Lecture 5: Bone

BIOL 4260 Human Evolu3onary Anatomy Lecture 5: Bone Development & Trunk Anatomy Lecture 2: Fossil Record
Segmentation
•  Cyclic genescreate segme ntation clock
for somite production
Final #s
4 occipital
8 cervical
12 thoracic
5 lumbar
5 sacral
4 coccygeal
Paraxial
mesoderm
somite
dermomyotome
and sclerotome
Fate of the
dermomyotome:
dermatome - dermis
myotome - muscles
Dermatome
Map:
Cutaneous
innervation of
skin follows
developmental
patterning
Myotome Fate
Epaxial and hypaxial muscles
Limb Buds
@ 4 weeks, C4-T1/2
@ 5 weeks, L1/2 -S3
Brains
Cranial end of neural
tube
More on this in 2
months
Summary & KeyPoints
•  Understand main stages of first few months
of life
•  Trace development of embryo during first
week, second week, third week
•  Understand gastrulation, neurulation,
segmental body organization
•  Trace fates of 3 germ layers & somites
(more on this next week)
BONES
Bone Markings
Q. Why would a bone have trochanter, tuberosi3es, etc. Microscopic Structure of Compact Bones
Spongy bone possess lamellae Chemical Composition of Bone
Bone consists of cells separated by an extracellular
matrix
35% organic components
Cells (osteoblast, osteoclasts, osteocytes) Osteoid -­‐ collagen fibers in ground substance composed of proteoglycans and glycoproteins Collagen – abundant in the ground substance and provides tensile strength 65% inorganic mineral salts invade the bone matrix
Primarily calcium phosphate Resists compression by making bone hard Osteogenesis: Bone (osteo) formation (genesis)
At six weeks of in-utero development, the skeleton is
composed of cartilage tissue or mesenchymal tissue
After six weeks bone begins to form by
Mesenchymal cells will be replaced by bone cells Car3lage cells will be replaced by bone cells This process of replacing other 3ssues with bone is called ossifica1on Calcification
The deposi3on of calcium ions into any 3ssue Though any 3ssue can be calcified, only ossifica3on results in bone forma3on Fetal Intramembranous and Endochondral
Ossification
10 week old human fetus
16 week old human fetus
Bone Development
Ossification (osteogenesis) – bone-tissue formation
Intramembranous ossifica1on Membranous bones – formed directly from (and within) mesenchyme. Mesenchyme is embryonic CT Bones of the roof of the skull (examples: frontal and parietal bones) and clavicles Begins about 8 weeks of fetal life Endochondral ossifica1on Bones develop from preexis1ng hyaline car1lage Involved in forma3on of all bones from base of the skull and many bones inferior to it such as limb bones, vertebrae, and hips Intramembranous (Dermal) Ossification
Endochondral Ossification
•  All bones except some bones of the skull and clavicles
•  Bones are modeled in hyaline cartilage
•  Begins forming late in the second month of embryonic
development
•  Continues forming until early adulthood
Stages in Endochondral Ossification
Fracture
Repair
Organization of Cartilage within
Epiphyseal Plate of Growing Long Bone
Epiphyseal Plates and Lines
Juvenile
Adult
Postnatal Growth of Endochondral Bones
During childhood and adolescence
•  Bones lengthen en3rely by growth of the epiphyseal plates •  Growing bones widen as they lengthen. •  Widening is achieved by addi3on of bone matrix by differen3a3on of the cells of the inner layer of periosteum into osteoblasts…..This is called apposi1onal growth •  Most bones stop growing in early childhood Appositional Bone Growth
- increases diameter of bone
Bone Remodeling
Bone is dynamic living tissue
•  500 mg of calcium may enter or leave the adult skeleton each day. •  Cancellous bone of the skeleton is replaced every 3 – 4 years •  Compact bone is replaced every 10 years •  Other real life examples: •  Realignment of teeth by orthodon3st •  Shrinking of bone following disuse •  Hardening of bone with exercise Bone Remodeling
•  Bone deposit and removal
•  Occurs at periosteal and endosteal surfaces •  Bone remodeling
•  Bone deposi1on – accomplished by osteoblasts (blast=Greek germinate) •  Bone reabsorp1on – accomplished by osteoclasts (clast=Greek to break). •  Summary: Bone remodeling is coordinated by a fine mix of osteoblast, osteocyte ac1vity •  Control: •  Indirectly via Calcium regula1on •  Directly arising from stresses Vertebral Column
Dual pillar system
for weight
bearing:
anterior/ventral
pillar (bodies) &
posterior/dorsal
pillar (arch)
Monotonic
increase in size of
body
The Axial Skeleton
80 named bones
Consists of:
skull-­‐22 bones associated bones Hyoid+6 auditory bones vertebral column bony thorax Support for head, neck,
trunk
Protection
The Vertebral Column
•  Formed from 26 bones in the adult
•  Supports and transmits weight of head, neck and
trunk to the appendicular skeleton of lower limbs
•  Surrounds and protects the spinal cord
•  Serves as attachment sites for the ribs and muscles
of the neck and back
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Held in place by ligaments
¤  Anterior and posterior longitudinal ligaments
¤  Ligamentum flavum
¤  Others
The Vertebral Column regions and Normal
curvatures
Vertebral column is divided into five major regions Four dis1nct curvatures give vertebral column an S-­‐shape Normal Curvatures
•  Four distinct curvatures give vertebral column
an S-shape
•  Primary: Thoracic and sacral curvatures •  Are convex posteriorly •  Secondary: Cervical and lumbar curvature •  Are concave posteriorly •  Curvatures increase the resilience of the spine
•  Note: In fetus, only the primary curves
present. Column therefore C shaped
Abnormal curvatures
•  Abnormal spinal curvatures
•  Scoliosis – an abnormal lateral curvature •  Kyphosis – an exaggerated thoracic curvature •  Lordosis – an accentuated lumbar curvature – “swayback” •  Stenosis of the lumbar spine
•  A narrowing of the vertebral canal Regions Vertebral Characteristics
•  Specific regions of the spine perform specific
functions
•  Types of movement that occur between
vertebrae
•  Flexion and extension •  Lateral flexion •  Rota3on in the long axis General features of vertebrae
•  A. Centrum-aka body: weight bearing
•  Separated by IV discs • 
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B. Pedicle paired: Encloses posteriolateral
C. Lamina paired
D. Spinous process
E. Transverse process paired
F. Neural arch b+c. Some people say
“A” contributes to arch. Not entirely accurate
G. Intervertebral disc
H. Articular facets
General Structure of Vertebrae
PLAY Spine (horizontal) Cervical Vertebrae
•  Seven cervical vertebrae (C1 – C7) – smallest
and lightest vertebrae
•  Atlas has no body or spinous process
•  Axis has unique odontoid process
•  C3 – C7 are typical cervical vertebrae
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Body is wider laterally, but small Spinous processes are short and bifid (except C7) Vertebral foramina are large and triangular Transverse processes contain transverse foramina Superior ar3cular facets face superoposteriorly Cervical Vertebrae
Cervical Vertebrae
The Atlas
•  C1 is termed the atlas
•  Lacks a body and spinous process
•  Supports the skull
•  Superior ar3cular facets are oval and receive the occipital condyles •  Inferior ar3cular facets are round •  Allows flexion and extension of neck
•  Nodding the head “yes” The Atlas