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The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression by Lorena Sánchez-Martín, Ana Estecha, Rafael Samaniego, Silvia SánchezRamón, Miguel Ángel Vega, and Paloma Sánchez-Mateos Blood Volume 117(1):88-97 January 6, 2011 ©2011 by American Society of Hematology Expression of CXCL12 receptors, CXCR4 and CXCR7, in blood monocytes and contribution to CXCL12 mediated-chemotaxis. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology Intracellular expression and secretion of CXCL12 and its role in monocyte to macrophage differentiation. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology Effect of CXCL12 on monocyte-DCs differentiation and maturation and immunogenic function. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology Most CXCL12+ cells in metastatic melanoma tissues are CD209+ and CD163+ tumor-associated macrophages that display a perivascular location and express CXCR4. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology CXCL12 induces the proangiogenic factors VEGF and CCL1. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology CXCL12 modulates the transcription factor RUNX3. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology RUNX3 mediates the effects of CXCL12 in CD4 and CD14 expression. Lorena Sánchez-Martín et al. Blood 2011;117:88-97 ©2011 by American Society of Hematology
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