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Transcript 
Vascular Matrix Metalloproteinase-2 Cleaves Big
Endothelin-1 Yielding a Novel Vasoconstrictor
by Carlos Fernandez-Patron, Marek W. Radomski, and Sandra T. Davidge
Circulation Research
Volume 85(10):906-911
November 12, 1999
Copyright © American Heart Association, Inc. All rights reserved.
Identification of MMP-2 in rat mesenteric arteries.
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
Role of MMP-2 on vasoconstrictor effects of big ET-1 on endothelium-denuded rat mesenteric
arteries.
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
Coinfusion of MMP-2–specific polyclonal antibody (α MMP-2), but not control rabbit IgG, dosedependently inhibited vasoconstriction of big ET-1 (50 pmol).
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
High-performance liquid chromatography analysis of products of big ET-1 cleavage by MMP-2.
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
Vasoconstrictor effects of ET-1[1–32].
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
Pharmacological characteristics of vasoconstrictor effects of ET-1[1–32].
Carlos Fernandez-Patron et al. Circ Res. 1999;85:906-911
Copyright © American Heart Association, Inc. All rights reserved.
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