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Colony-Stimulating Factors Signal for Increased Transport of Vitamin C in Human Host Defense Cells by Juan Carlos Vera, Coralia I. Rivas, Rong H. Zhang, and David W. Golde Blood Volume 91(7):2536-2546 April 1, 1998 ©1998 by American Society of Hematology Transport of dehydroascorbic acid by human neutrophils and monocytes. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology Human neutrophils and monocytes take up dehydroascorbic acid through facilitative glucose transporters. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology GM-CSF and G-CSF increase the uptake of dehydroascorbic acid (DHA) by human neutrophils and monocytes. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology GM-CSF increases the transport of dehydroascorbic acid by HL-60 neutrophils. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology GM-CSF increases the accumulation of ascorbic acid by HL-60 neutrophils. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology Effect of GM-CSF on the uptake of deoxyglucose (DOG) and methylglucose (OMG) by HL-60 neutrophils. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology Effect of fMetLeuPhe on the uptake of dehydroascorbic acid (DHA) and ascorbic acid (AA) by HL-60 neutrophils. Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology Regulatory steps involved in the cellular uptake of vitamin C. We identified three possible regulatory sites at which HL-60 neutrophils regulate their uptake and content of vitamin C. These steps are also likely active in cells such as human neutrophils and... Juan Carlos Vera et al. Blood 1998;91:2536-2546 ©1998 by American Society of Hematology