Download PPT - Blood Journal

Colony-Stimulating Factors Signal for Increased Transport
of Vitamin C in Human Host Defense Cells
by Juan Carlos Vera, Coralia I. Rivas, Rong H. Zhang, and David W. Golde
Blood
Volume 91(7):2536-2546
April 1, 1998
©1998 by American Society of Hematology
Transport of dehydroascorbic acid by human neutrophils and monocytes.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
Human neutrophils and monocytes take up dehydroascorbic acid through facilitative glucose
transporters.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
GM-CSF and G-CSF increase the uptake of dehydroascorbic acid (DHA) by human neutrophils
and monocytes.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
GM-CSF increases the transport of dehydroascorbic acid by HL-60 neutrophils.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
GM-CSF increases the accumulation of ascorbic acid by HL-60 neutrophils.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
Effect of GM-CSF on the uptake of deoxyglucose (DOG) and methylglucose (OMG) by HL-60
neutrophils.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
Effect of fMetLeuPhe on the uptake of dehydroascorbic acid (DHA) and ascorbic acid (AA) by
HL-60 neutrophils.
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology
Regulatory steps involved in the cellular uptake of vitamin C. We identified three possible
regulatory sites at which HL-60 neutrophils regulate their uptake and content of vitamin C. These
steps are also likely active in cells such as human neutrophils and...
Juan Carlos Vera et al. Blood 1998;91:2536-2546
©1998 by American Society of Hematology