Download Powerpoint - Blood Journal

Platelets mediate increased endothelium permeability in
dengue through NLRP3-inflammasome activation
by Eugenio D. Hottz, Juliana F. Lopes, Carla Freitas, Rogério Valls-de-Souza,
Marcus F. Oliveira, Marcelo T. Bozza, Andrea T. Da Poian, Andrew S. Weyrich, Guy
A. Zimmerman, Fernando A. Bozza, and Patricia T. Bozza
Blood
Volume 122(20):3405-3414
November 14, 2013
©2013 by American Society of Hematology
IL-1β synthesis in DV-infected platelets and platelets from healthy volunteers.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
Dengue induces shedding of IL-1β–rich microparticles in platelets.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
Activation of the NLRP3 inflammasome in platelets from DV-infected patients.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
Platelet shedding of IL-1β–rich MPs depends on caspase-1 activation.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
DV-elicited inflammasome activation depends on mitochondrial-derived ROS and RIP kinases.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
Vascular permeability is associated to platelet shedding of IL-1β–containing MPs. A-C show the
percentage of (A) IL-1β–expressing platelets and (B) IL-1β–containing platelet-derived MPs and
(C) the MFI of FLICA indicating caspase-1 activation in platelets i...
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology
Schematic representation for DV-induced platelet shedding of IL-1β–containing MPs. Platelets
synthesize IL-1β after DV exposure.
Eugenio D. Hottz et al. Blood 2013;122:3405-3414
©2013 by American Society of Hematology