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Microbiome Ltd. The perfect DNA test for Chlamydia trachomatis (CT) infections Paul H.M. Savelkoul, Arnold Catsburg & Servaas A. Morré The disease * C. trachomatis: most prevalent sexually transmitted disease (STD) * 80% asymptomatic in women: mostly undetected & untreated * Untreated CT: ectopic pregnancy & tubal infertility * Treatment: easy 100% effective antibiotic treatment The commercial potential * 60.000 CT infections in the Netherlands * Up to 18% prevalence in high risk populations * Multi million annual tests market world-wide * 12 Dutch hospitals already use our test in home-brew format * Dutch CT screening initiated 16 April 2008. * Extension to other STDs in progress EXCELLENT COMMERCIAL OPPORTUNITIES The principle - No false negatives Isolate DNA out of clinical specimen Clinical specimen Perform patented CT PCR Highly validated test result - 10 x more sensitive (test patented) - New internal control (patented) - Monitoring all test steps Add patented internal control - Suited for every human specimen Impact for society Rapid, sensitive, controlled detection enables early Microbiome Name company: Microbiome Ltd. Origin: Spin-off company VU University Medical Center treatment of C. trachomatis infections. Company profile: (Medical) Microbiological detection, typing and laboratory consultancy Transmission of the infection among the population and severe complications like tubal infertility and adverse Directors & CEOs: Prof.dr. PHM Savelkoul & Dr. SA Morré E-mail: [email protected] & [email protected] Date of invention in 2007: 26 March 2007 pregnancy outcome will be reduced. Chlamydia test patent: 2008 CE certification: end of 2008