Download CSC Conference program

Conference Directors: Jeremy Rich, Stanton Gerson, Arnold Caplan, Justin Lathia, and Huiping Liu
Sunday, August 17th
12:00PM
Arrival and Early Registration
Pre-Session – NIH Grants and Career Development Workshop (Chairperson: Huiping Liu)
2:00-2:30
Suresh Mohla, PhD (NIH ⁄ NCI): R01 Grants Overview
2:30-3:00
Angela Ng, PhD (NIH ⁄ CSR) : R01 Grant Review
3:00-3:30
Ming Lei, PhD (NIH ⁄ NCI) : Training and Career Development Awards
3:30-3:50
Justin Lathia, PhD (Cleveland Clinic), From K Awards to R01
3:50-4:10
Jill Barnholtz-Sloan, PhD (Case Western Reserve University): Biostatistics in Grants
4:10-4:40
Panel discussions
4:40PM
BREAK
Opening Session (Chairperson: Stanton Gerson, MD)
5:00-5:05
Welcome from Stanton Gerson
5:05-5:15
Opening Remarks from Dr. Jeremy Rich
Keynote Speaker: The Master Regulators of Stem Cells and Cancer in the Brain
5:15-5:45
Antonio Iavarone, MD (Columbia University)
Tumor Vascular Regulation of Stem Cell Asymmetric Division and Metastasis
5:45-6:15
Ronald J. Buckanovich MD, PhD (University of Michigan)
Dual Roles of EphA2 in Regulating Invasive Propensities of Brain Tumor Initiating Cells
6:15-6:35
Bingcheng Wang, PhD (Case Western Reserve University)
Investigating the Cell of Origin for Prostate Cancer
6:35-6:55
Michael M. Shen, PhD(Columbia University Medical Center)
SHORT TALK 1: Role of Exosomal Subsets in the Induction of Epithelial to
6:55-7:05
Mesenchymal Phenotype
Ganesh Shelke (Krefting Research Centre)
7:15
Reception(Cocktails & Heavy Hors D'oeuvres)
Monday, August 18th
8:30-8:45AM
8:45-9:20
Welcome Remarks
Justin Lathia, PhD (Cleveland Clinic) & Huiping Liu, MD, PhD (CWRU)
Keynote Speaker- Normal and Neoplastic Stem Cells
Irving Weissman, MD (Stanford School of Medicine)
Session I- Genetics (Chairperson: Justin Lathia, PhD)
Mouse Models of Glioma: Stem Cells
9:20- 9:40
Luis Parada, PhD (UT Southwestern Medical Center)
Stem Cells, Sexual Identity, and Tumors in the Drosophila Ovary
9:40-10:00
Helen Salz, PhD (Case Western Reserve University)
Target PIK3CA/p110 Alpha Mutations for Cancer Therapy
10:00-10:10
Zhenghe John Wang, PhD (Case Western Reserve University)
SHORT TALK 2: Ex Vivo Culture of Circulating Breast Tumor Cells for Testing Drug
10:10-10:20
Sensitivity and Cancer Stem Cell Properties
Min Yu, PhD (University of Southern California)
10:20-10:30
10:30-11:00
SHORT TALK 3: Sema3C Promotes The Survival and Tumorigenicity of Glioma Stem
Cells Through Rac1 Activation
Jianghong Man, PhD (Cleveland Clinic)
BREAK
Session II- Brain Tumor Session (Chairperson: Justin Lathia, PhD)
CIMP Phenotype in Posterior Fossa Ependymomas of Infancy
11:00-11:20
Michael Taylor, MD, PhD (Hospital for Sick Children, University of Toronto)
Glioblastoma Stem Cells and Vascular Pericytes
11:20-11:40
Shideng Bao, PhD (Cleveland Clinic)
Multiple Strategies for Cancer Stem Cell Targeting
11:4012:00PM
Ruggero De Maria, MD (Italian National Institute of Health)
SHORT TALK 4: Differential Connexin Function Enhances Self-Renewal in
12:00-12:10
Glioblastoma
Masahiro Hitomi, MD, PhD (Cleveland Clinic)
SHORT TALK 5: The Therapeutic Potential of Prostate Apoptosis Response-4 Against
12:10-12:20
Glioma Stem Cells
Craig Horbinski, MD, PhD (University of Kentucky)
Sponsor Lunch Discussion - Fluidigm
12:20-1:20
Session III- Microenvironment and New Concepts (Chairperson: Huiping Liu, MD, PhD)
Keynote Speaker: MSCs: The Gatekeepers for Metastasis
1:30-2:00
Arnold Caplan, PhD (Case Western Reserve University)
Featured Speaker: Hypoxia, Metabolism, and Stem Cells
2:00-2:30
M. Celeste Simon, PhD (University of Pennsylvania)
Exosomes and other Subgroups of Extracellular Vesicles – The New Nanocosmos in
2:30-2:50
our Body
Jan Lötvall, MD PhD (University of Gothenburg)
Silencing Self-Renewal: Identifying and Targeting Cancer Stem Cell Communication
2:50-3:10
Mechanisms
Justin Lathia, PhD (Cleveland Clinic)
SHORT TALK 6: Tumor-Promoting Microenvironment in Epithelial Transition Zones
3:10-3:20
Geraldine Guasch, PhD (Cincinnati Children’s Hospital Medical Center)
SHORT TALK 7: Gremlin-1, a Bone Morphogenetic Protein Antagonist, Inhibits
3:20-3:30
Cytokine Induced Epithelial-Mesenchymal Transition & Acquisition of Cancer Stem Cell
Properties
Jacob Smigiel (Case Western Reserve University)
BREAK
3:30-4:00
Session IV- Metabolism and Inflammation (Chairperson: Arnold Caplan, PhD)
Glioblastomas; Adaptive Mechanisms to Anti-Vascular Therapy
4:00-4:20
Rolf Bjerkvig, PhD (University of Bergen)
Leptin Receptors Integrate Metabolic Cues in Breast Cancer Stem Cells
4:20-4:40
Ofer Reizes, PhD (Cleveland Clinic)
Colon Cancer Initiating Cells and the Inflammatory Niche
4:40-5:00
Emina Huang, MD (Cleveland Clinic)
Dynamic Neutrophil Response in the Bone Marrow to Systemic LPS Exposure
5:00-5:15
Alex Huang, MD, PhD (Case Western Reserve University)
Proneural-Mesenchymal Transformation of Glioma Stem Cells
5:15–5:30
Ichiro Nakano, MD, PhD (Ohio State University)
SHORT TALK 8: A Novel Approach for Targeting Iron Metabolism in Cancer Stem Cells
5:30-5:40
David Schonberg (Cleveland Clinic)
SHORT TALK 9: Combined Upregulation of KDM5 and EZH2 Defines Most Aggressive
5:40-5:50
Breast Cancer Phenotype
Elizaveta Benevolenskaya (University of Illinois at Chicago)
5:50-6:20
Siemens- The Baton Pass™ / Stand Up To Cancer
Pamela B. Davis, MD, PhD (Case Western Reserve University School of Medicine)
Gregory Sorenson, MD (Siemens Healthcare USA)
Jeremy Rich, MD (Cleveland Clinic Lerner Research Institute)
Brian J. Bolwell, MD (Cleveland Clinic Taussig Cancer Institute)
Stanton L. Gerson, MD (Case Comprehensive Cancer Center)
Session V- Poster Lightening Round 1 (Chairperson: Arnold Caplan)
Poster Teaser 1: Small Molecule ONC201/TIC10 Targets Chemotherapy-Resistant
6:20-6:25
Colorectal Cancer Stem Cells in Vitro and in Vivo in an Akt- and TRAIL-Dependent
Manner
Varun Vijay Prabhu (Penn State Hershey Cancer Institute)
Poster Teaser 2: Deregulated IL8/CXCR1 Autocrine Circuit Sustains the Long-Term
6:25-6:30
Colon Cancer Stem Cell
Robert Fisher (Cleveland Clinic)
6:30-8:00PM
Poster Presentation I (Cocktails & Heavy Hors D’oeuvres)
Tuesday, August 19th
Session VI- Epithelial Tumor Stem Cells (Chairperson: Jeremy Rich, MD)
8:00-8:20AM Microenvironmental Control of Lung Stem Cells and Lung Cancer
Carla Kim, PhD (Harvard University)
Self-Renewal as a Therapeutic Target in Human Colorectal Cancer
8:20-8:40
Catherine O'Brien, MD (University of Toronto)
Epigenetic Targeting of Ovarian Cancer Stem Cells
8:40-9:00
Kenneth Nephew (Indiana University)
Stem Cell Pathway Addiction in Human Tumors
9:00-9:15
Austin Gurney, PhD (OncoMed Pharmaceuticals)
Keynote Speaker: Molecular Regulation of Self Renewal in Cancer Stem Cells
9:15-9:45
Michael Clarke, MD (Stanford University)
SHORT TALK 10: Oncostatin-M-Induced Senescence in Human Mammary Epithelial
9:45-9:55
Cells Acts as a Barrier to Cancer Stem Cell Properties
Benjamin Bryson (Case Western Reserve University)
BREAK
9:55
Session VII- Metastasis (Chairperson: Jeremy Rich, MD)
Featured Speaker: Cancer Stem Cell Markers and the Prediction of Distant Recurrence
10:20-10:50
of Breast Cancer
John Condeelis, PhD (Albert Einstein College of Medicine)
Tackling Breast Cancer Stem Cells, Metastasis and Chemoresistance
10:50-11:10
Huiping Liu, MD, PhD (Case Western Reserve University)
How Cancer Cells Acquire Metastatic Traits
11:10-11:30
Yibin Kang, PhD (Princeton University)
Mammary Epithelial Transformation and Metastasis: Role of Transient EMT:MET
11:30-11:50
Programs
William Schiemann, PhD (Case Western Reserve University)
SHORT TALK 11: Therapeutic Targeting of Distinct Subsets of Cancer Stem Cells
11:50Within Triple Negative Breast Cancers
12:00PM
Diana Azzam (University of Miami)
SHORT TALK 12: Analysis of Circulating Tumor and Cancer Stem Cells Using
12:00-12:10
Microfluidics
Sunitha Nagrath (University of Michigan)
Sponsor Lunch Discussion – Panasonic Healthcare
12:10-1:15
Session VIII- DNA and Tumorigenesis (Chairperson: Huiping Liu, MD, PhD)
DNA Repair Deficiency and Leukemia Genesis
1:30-1:50
Stanton Gerson, MD (Case Western Reserve University)
Regulation of Tet Family of DNA Dioxygenases
1:50-2:10
Yue Xiong, PhD (University of North Carolina at Chapel Hill)
15-PGDH: a Potent Regulator of Carcinogenesis in the Colon Crypt
2:10-2:30
Sanford Markowitz, MD, PhD (Case Western Reserve University)
The Role of Stem Cells, EMT and the Microenvironment in Resistance to Therapy for
2:30-2:50
Breast Cancer
Lyndsay Harris, MD (Case Western Reserve University)
SHORT TALK 13: A Role for Interferon Beta (IFNβ) in Suppressing Breast Cancer
2:50-3:00
Tumor Recurrence
Mary Doherty (Case Western Reserve University)
SHORT TALK 14: Collagen's Role in Glioblastoma Tumor Invasion and Patient Survival
3:00-3:10
Kelli Pointer (University of Wisconsin-Madison)
SHORT TALK 15: ALDH Inhibition as a Trigger for Necroptotic Cell Death of Ovarian
3:10-3:20
Cancer Stem Cells
Ilana Chefetz Menaker (University of Michigan)
BREAK
3:20
Session IX- Heterogeneity and Therapeutic Resistance (Chairperson: Stanton Gerson, MD)
Brain Tumor Stem Cells
3:50- 4:20
Keynote Speaker: Jeremy Rich, MD (Cleveland Clinic)
Spatial and Temporal Heterogeneity in Human Cancers: Single Cell Genotype and
4:20-4:40
Phenotype in Prostate Cancer Patients
Peter Kuhn, PhD (USC)
Imaging Cancer Heterogeneity and Therapy Resistance in Real Time
4:40-5:00
Tannishtha Reya, PhD (UC San Diego)
Prostate Cancer Stem Cells and Therapy Resistance
5:00-5:20
Dean Tang, PhD (University of Texas)
Targeting Glioma Initiating Cells in GBM: A Randomized Phase 0/II Study Targeting the
5:20-5:30
Sonic Hedgehog-Signaling Pathway in Recurrent GBM
Andrew Sloan, MD (Case Western Reserve University)
Targeting Brain Tumor Stem Cells: A Phase II Trial of RO4929097 Targeting the Notch
5:30-5:40
Pathway in Recurrent Glioblastoma
Manmeet Ahluwalia, MD (Cleveland Clinic)
Development of Cancer Stem Cell Inhibitors
5:40-5:50
Wei Li (Boston Biomedical)
Session X- Poster Lightening Round 2 (Chairperson: Stanton Gerson, MD)
Poster Teaser 3: Chemosensitivity Assay for Targeting Cancer Stem-Like Cells in
6:00-6:05
Malignant Brain Tumors
Pier Paolo Claudio (Marshall University)
Poster Teaser 4: Divergent Lipid Metabolism Drives Self-Renewal in Glioblastoma
6:05-6:10
James Hale (Cleveland Clinic)
Poster Teaser 5: Targeting Mitotic Kinesins to Inhibit Proliferation and Invasion of
6:10-6:15
Glioblastoma Stem Cells
Monica Venere (Cleveland Clinic)
6:20-8:00
Poster Presentation II (Cocktails & Heavy Hors D’oeuvres)
Wednesday, August 20th
Session XI- Epigenetics and RNAs (Chairperson: Jeremy Rich, MD)
8:00-8:20AM Keynote Speaker: Solid Tumor Stem Cells
8:20-8:40
8:40-8:55
8:55-9:10
9:10-9:25
9:25-9:40
9:40-9:50
9:50-10:00
10:00
Bradley Bernstein, MD, PhD (Massachusetts General Hospital)
miR-126 and Leukemia Stem Cells in Acute Myeloid Leukemia
Jianjun Chen, PhD (University of Chicago)
Epigenetic Regulation of Prometastatic Transcriptional Programs
Peter C. Scacheri, PhD (Case Western Reserve University)
AML Stem Cells
David Wald, MD, PhD (Case Western Reserve University)
Cancer: Origination in Stem Cells but Initiation by Progenitors
Yogen Saunthararajah, MD (Cleveland Clinic)
RNA Recoding and Malignant Progenitor Reprogramming
Catriona Jamieson MD, PhD (Moores UC San Diego Cancer Center):
SHORT TALK 16: Spatiotemporal Control of Cancer Stem Cell Asymmetric Division by
Versatile microRNA Mechanisms
Xiling Shen (Cornell University)
SHORT TALK 17: Loss of Tumor Suppressive MicroRNA-31 Enhances TRADD/NF-kB
Signaling in Gliomas
Susan Nozell (University of Alabama at Birmingham)
BREAK
Session XII- Development and Evolution (Chairperson: Justin Lathia, PhD)
Wnt ß-catenin Signaling: Developmental Insight into Tumor Heterogeneity
10:30-10:50
Jeffrey Rosen, PhD (Baylor College of Medicine)
Is There a Role for Fundamental Developmental Stem Cell Biology in Understanding
10:50-11:10
the Genesis & Treatment of CNS Neoplasms?
Evan Snyder, MD, PhD (Sanford-Burnham Medical Research Institute)
Asymmetry-Defective Cells with Oligodendrocyte Progenitor Characteristics in
11:10-11:30
Astrocytoma
Claudia Petritsch, PhD (UC San Francisco)
Interrogating the Clonal Evolutionary Dynamics in Glioblastoma: Spatial and Temporal
11:30-11:50
Perspectives
Collin Watts, MBBS, PhD, FRCS, HEFCE (Cambridge University)
Transcriptional Control of Breast Epithelial Cell States
11:50-12:10
Ruth Keri, PhD (Case Western Reserve University)
Roles of EZH2 in Cancer
12:10-12:30
Jeongwu Lee, PhD (Cleveland Clinic)
SHORT TALK 18: Mathematical Modeling of Hypoxic Glioma Stem Cell Niches
12:30-12:40
Suggests Rapid Selective Evolutionary Dynamics
Jacob Scott (H. Lee Moffitt Cancer Center and Research Institute)
SHORT TALK 19: Hunting the Pre-Malignant Stem Cells in Human Glioblastoma
12:40-12:50
Multiforme
Siddhartha Mitra (Stanford University School of Medicine)
SHORT TALK 20: The Tumor Suppressive Role of MIR-663 and Its Prognostic Value in
12:50-1:00
Human Glioblastoma
Yu Shi (Institute of Pathology and Southwest Cancer Center, China)
CLOSING REMARKS
1:00 PM
Stanton Gerson, MD (Case Western Reserve University)