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47. Robert. Song, Zhenguo Zhang, Gil Mor, Richard J. Santen. Down-regulation of Bcl-2 enhances
estrogen apoptotic action in ER+ post-menopausal breast cancer cells. Apoptosis, 2005 (Accepted).
46. Robert X. Song, Zhenguo Zhang, Richard J. Santen. A Novel Role of EGFR and Shc in ERa
Membrane Translocation and Activation of MAPK in Breast Cancer Cells. The Endocrine Society’s 86th
Annual Meeting, 2004, OR4-4, 74
45. Zhenguo Zhang, Rakesh Kumar, Richard J. Santen and Robert X-D. Song. The role of adapter
protein Shc in estrogen non-genomic action. Steroid 2004, 69, 523-530.
44. Song RX, Chris Barne, Zhenguo Zhang, Yongde Bao, Rakesh Kumar and Richard J. Santen. The
role of Shc and IGF-1R in mediating the translocation of ERa to the plasma membrane. PNAS 2004,
101(7), 2076-2081
43. Santen,R.J.; Song, R.X.; Zhang, Z.; Yue,W.; Kumar,R. Adaptive hypersensitivity to estrogen:
mechanism for sequential responses to hormonal therapy in breast cancer. Clinical Cancer Res. 10,
337S-345S, .2004
42. Robert X-D Song, Zhenguo Zhang, Richard J Santen. Membrane-Targeted Era mediates the Effects
of 17β-Estradiol on MAPK Activation and Cell Proliferation. The Endocrine Society’s 84th Annual Meeting,
2003, OR 27-6, 101-102
41. Santen,R.J, Song,R.X., Zhang,Z, Kumar, R. Jeng,M.H., Masamura,S., Yue,W., Berstein,L..
International Congress on Hormonal Steroids and Hormones and Cancer: Adaptive hypersensitivity to
estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators
for breast cancer treatment and prevention. Endocr.Relat Cancer 2003, 10(2) 111-130.
40. Robert X-D Song; Zhenguo Zhang; Yongde Bao; Michael J Black; Richard J Santen. IGF-1 receptor
activation and it’s physical interactions with adapter protein Shc and ER mediate the non-genomic action
of estradiol in breast cancer cells. The Endocrine Society’s 85th Annual Meeting, 2003, P2-125, 337.
39. Zhenguo Zhang; Richard J. Santen; Robert X-D Song. MAP kinase negtively regulates estrogen
receptor-mediated transcriptional activity in human breast cancer cells. The Endocrine Society’s 85th
Annual Meeting, 2003, P1-135, 166.29.
38. Zhenguo Zhang; Richard J. Santen; Robert X-D Song. Antiestrogens and estrogens regulate cell
proliferation and apoptosis differently in Long-Term- Estrogen-Deprived and wild type MCF-7 cells. The
Endocrine Society’s 85th Annual Meeting, 2003, P1-134, 165.
37. Zhenguo Zhang, Berhard Maier, Richard J. Santen, and Robert X.-D. Song. Membrane association of
estrogen receptor mediates an estrogen effect on MAPK activation. Biochemical and Biophysical
Research Communication, 294 (2002), 926-933.
36. Xingsheng Yang, Zhenguo Zhang, Chongqi Jia, Jiafu Li, Lijj Yin, and Sen Jiang. The relationship
between expression of c-ras, c-erbB-2, nm23, and p53 gene products and development of trophblastic
tumor and their predictive significance for the malignant transformation of complete hydatidiform mole.
Gynecologic Oncology, 85, 438-444, 2002.
35. Robert X. Song, L Adam, R. Kumar, Zhenguo Zhang, Richard J. Santen. Up- regulation of an
estradiol mediated, non-genomic pathway involving Shc and MAPK in breast cancer cells adapted to
long-term estrogen deprivation. The Endocrine Society’s 83th Annual Meeting, 2001, P1-39, 158.
34. Robert X.-D. Song, Gil Mor, Fred Naftolin, Robert A. McPherson, Joon Song, Zhenguo Zhang, Wei
Yue, JiPing Wang, Richard J. Santen. Effect of long-term estrogen deprivation on apoptotic responses of
breast cancer cells to 17b-estradiol. Journal of the National Cancer institute. Vol. 93, No.22, 1714-1723,
November 21, 2001.
33. Z. Zhang, D.R.Abernethy, N.M.Soldatov. Age-dependent switch in expression of human Ca2+
channel a1c subunit isoforms. ASBMB/ASPET Joint Meeting, June 2000. Boston.
32. Zhenguo Zhang, Gengyin Zhou, Lingling Guo. Upper abdomen indisposition, hematemesis and
sudden death: autopsy analysis and cilnical discussion. Chinese Journal of Pathology, Vol 28, No.5, 1999
31. Xiangjun Yang, Zhenguo Zhang, Qun Zeng. A study of expression of p53, C-myc and PCNA in
retinoblastoma. Chinese Journal of Ophthalmology, Vol.35, No.4, 1999.
30. Xingsheng Yang, Zhenguo Zhang, Youzheng Zhang. The predicting value of C-Ha-ras, C-erbB2, p53
and nm23 gene products in malignant transformation of hydatidiform mole. Current Advances in
Obstetrics & Gynecology. Vol.7, No. 2, 1998
29. Yang Xingsheng, Zhenguo Zhang, Zhang Youzhong, et al. The role of antioncogene in the malignant
transformation of hydatidiform mole. Acta Academiae Medicine Shandong, 1998, 36: 165
28. Zhenguo Zhang, Xu Miaohou, Li Shengmei. Case report: Primary fallopian malignant mesodermal
mixed tumor. Chinese Journal of Pathology, 1998; 24: 56
27. Zhenguo Zhang , Xu Miaohou, Lichen, et al. The clinical usage of detection of C-erbB-2 in breast
benign and malignant diseases. The Chinese Current Advances of Cancer, 1998(vol.4): 326
26. Zhenguo Zhang, Xu Miaohou, Yu Chenghao. The role of Dept. of Pathology in general hospital.
Chinese Journal of Hospital Administration 1998; 14: 604
25. Zhenguo Zhang, Xu Miaohou. The expression and clinical significance of p16 in endometrial
carcinomas. Chinese Journal of Senior Medicine, 1998; 4
24. Yang Xingsheng, Zhenguo Zhang, Zhang Youzhong, et al. Study on the role of oncogenes and
gestational trophoblastic cell proliferative activity in malignant transformation of hydatidiform mole.
Current Advances in Gynecology & Obstetrics. 1997, 6: 213
23. Xu Miaohou, Zhenguo Zhang, Jing sen, et al. The study of endocrine charicteristics of luteal phase
defect and inadequate endometrial response. Chinese Journal of Gynecology & Obstetrics, 1997; 32: 14
22. Zhenguo Zhang, Xu Miaohou, Pang Liyi, et al. Study of overexpression of p53 in ovarian epithelial
carcinomas. Acta Academiae Medicinae Shandong, 1997; 35: 293
21. Zhenguo Zhang, Li Shengmei, Wang Yuanfu, et al. The significance of over-expression of p53 in
malignant lymphomas. Guo Wai Yi Xue: Oncology(Supple), 1997; 24: 56
20. Zhenguo Zhang, Xu Miaohou, Wang Meiqing. A clinicopathologic study of 110 cases of endometrial
carcinomas. Acta Academiae Medicinae Shandong, 1997; 35: 293
19. M.H.Xu, Z.G.Zhang, Q.Lu, et al. Study on the determination of p16 in endometrial carcinomas by
using immunohistochemistry and its clinical significance. Current Advances in Obstetetris & Gynecology,
1997; 6: 320
18. Zhenguo Zhang, Jianman Sun, Miaohou Xu, Hong Li, Chen Li. Expression of EGFR, c-erbB-2 in
benign and malignant breast diseases and their clinical significance. Chinese Medical Association
Meeting: Tumor Gene Diagnosis and Therapy. Dec. 1997. Guangxi.
17. Gengyin Zhou, Meisheng Li, Zhenguo Zhang, Xiaojuan Wang, Wenjun Liu. Gliosarcoma: Pathological
slides viewing and analysis. Journal of Clinical and Experenment Pathology, Vol. 13, No.2 (171), May
1997.
16. Baoxia Cui, Wenyao Zhang, Sen Jiang, Zhenguo Zhang, Xingsheng Yang. The overexpression and
clinical significance of p53, C-erbB2, C-ras and C-myc in ovary granulosa cell tumor. Current Advances in
Obstetrics & Gynecology, Vol.6, No. 2, 1997.
15. Zhenguo Zhang, Miaohou Xu, Meiqing Wang. Study on estrogen and progesterone receptors in
human endometrium with immunohistochemistry. Guo Wai Yi Xue: Clinical biology and Examination. Vol.
18 (Suppl.), 1997
14. Duo Wang, Zhuping Wang, Yanhong Wang, Zhenguo Zhang. Observing the distribution of cell
dendrity in dentin by marketing Vimentin. Vol. 35, No.4, 1997
13. Miaohou Xu, Zhenguo Zhang, Shuhua Lu. Etiology and advances in therapy for recurrent
spontaneous abortion(1). Zhong Ji Yi Kan, Vol. 32, No. 7, 1997
12. Miaohou Xu, Zhenguo Zhang, Shuhua Lu. Etiology and advances in therapy for recurrent
spontaneous abortion(2). Zhong Ji Yi Kan, Vol. 32, No. 8, 1997
11. Miaohou Xu, Zhenguo Zhang. Review: The examination of SCC for cervical carcinoma in clinical
using. Guo Wai Yi Xue: Oncology (Supple.), Vol.23, 209, Dec. 1996.
10. M.H.Xu, Z.G.Zhang. A case analysis: neonatal death due to rupture of blood vessel previa in
velamentous placenta. Current Advances in Obstetrics & Gynecololgy, 1996; 5: 295
9. Zhenguo Zhang, Xu Miaohou. The new considers about cancer research. Acta Academiae Medicinae
Shandong (Social Sciences Edition), 1996; 35:29
8. Zhenguo Zhang, Meiqing Wang. Study on estrogen receptor expression in endometrial carcinomas
with immunohistochemistry using monoclonal antibady. 2nd Meeting of Sino-American New Pathological
Technologics Development. Oct. 1995. Fuzhou
7. Zhenguo Zhang, Xu Miaohou, Wang Meiqing. Study on relationships between AgNORs and prognosis
of endometrial carcinomas. Current Advances in Gyneco and Obstet. 1995; 4:348
6. Genyin Zhou, Zhenguo Zhang, Wenlong Cao, Wenjun Liu, et al. Case report. Sudden death due to
embolism of pulmonary artery: Clinical- pathological analysis. Shandong Medical Journal, 1995, 35(8):54
5. Aijun Liu, Meiqing Wang and Zhenguo Zhang. Immunohistochemical study of ER and PR in ovarian
epithelial tumors. Current Advances in Obstetrics and gynecology 3(3): 208, 1994.
4. Zhenguo Zhang, Miaohou Xu, Meiqing Wang and Sen Jiang. Expression of estrogen receptors in
endometrial carcinoma with immunobloting analysis. Chinese Journal of Gynecology and Obstetrics,
29:667,1994.
3. Zhenguo Zhang. Immunohistochemical study of estrogen receptor (ER) and progesterone receptor
(PR) in endometrium of normal circle. Chinese Journal of Pathophysiology 9(1): 96, 1993.
2. Zhenguo Zhang, Meiqing Wang. Immunohistochemical detection of estrogen receptor (ER) in
endometrial carcinoma. Chinese Journal of Pathology 22(4): 227; 1993
1. M.H.Xu, Z.G.Zhang. To analyse the importance of developing the basic sciences in our country from
the relationship between basic and applying sciences. Acta Academiae Medicinae Shandong (Social
Science Edition), 1992; 31: 71.