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Thomas Clavel
TU München
ZIEL Institute for Food and Health
Research Group Intestinal Microbiome
www.clavel-research.com
www.ziel.tum.de
Ilias
Lagkouvardos
Martin
Kapfhammer
Divya
Joseph
Sabahattin
Giritli
Microbes are very important on earth!
Anaerobic cultivation
High-throughput 16S rRNA gene amplicon SEQUENCING
16S rRNA
Make use of stored 16S sequencing data via IMNGS
Sequence Read Archive
(SRA)
DB of 88,579 samples
Test ecological relevance
of target bacteria
Study the diversity of
specific bacterial taxa
www.imngs.org
In the future…
Literature
1. Lagkouvardos, Joseph, Kapfhammer, Giritli, Horn, Haller, Clavel (2016) IMNGS:
A massive open resource of processed 16S rRNA microbial profiles for ecology
and diversity studies. Sci Rep 6:33721
2. Lagkouvardos, […] Overmann, Stecher, Clavel (2016) The mouse intestinal
Bacterial Collection (miBC) provides host-specific insight into cultured diversity
and functional potential of the gut microbiota. Nature Microbiol 1:16131
3. Lee,* Clavel,* […] Haller (2016) Oral versus intravenous iron replacement
therapy distinctly alters the gut microbiota and metabolome in patients with
inflammatory bowel diseases. Gut, doi: 10.1136/gutjnl-2015-309940
4. Clavel, Lagkouvardos, Hiergeist (2016) Microbiome sequencing: challenges and
opportunities for molecular medicine. Expert Rev Mol Diagn 16:795
5. Lagkouvardos, […] Rohn, Skurk, Clavel (2015) Gut metabolites and bacterial
community networks during a pilot intervention study with flaxseeds in healthy
adult men. Mol Nutr Food Res 59:1614