Download SDC 2. Pathogens Detected in 495 Specimens via Viral Culture and

SDC 2. Pathogens Detected in 495 Specimens via Viral Culture and Real-Time PCR Assays
Viruses
No. of pathogens by PCR No. of viruses by culture Viral detection ratesa Co-infection rateb N0. of patientsc Mean age (months)
RSV
138
71
51.5%
26.8%
138
33.3 ± 19.5
hMPV
66
15
22.7%
18.2%
66
37.9 ± 17.5
PIV1-3
73
29
39.7%
39.7%
73
35.8 ± 25.7
Type 1
20
6
30.0%
40.0%
20
39.1 ± 24.4
Type 2
17
6
35.3%
41.2%
17
53.9 ± 22.6
Type 3
36
17
47.2%
38.9%
36
25.4 ± 23.0
Adenovirus
124
118
95.2%
29.0%
124
37.7 ± 24.1
Type 1
NA
24
NA
Type 2
NA
45
NA
Type 3
NA
36
NA
Type 5
NA
11
NA
Type 6
NA
2
NA
Rhinovirus
23
2
8.7%
56.5%
23
33.6 ± 35.5
Enterovirus
35
19d
NA
68.4%
38d
38,3 ± 26.6
Influenza C virus
11
0
0%
81.8%
11
29.5 ± 16.2
M. pneumoniae
15
NA
NA
20.0%
15
76.8 ± 30.2
C. pneumoniae
3
NA
NA
66.7%
3
60.7 ± 12.1
Human parechovirus NA
5
NA
NA
5
27.2 ± 18.6
HSV-1
NA
3
NA
NA
3
31.0 ± 13.9
Mumps virus
NA
1
NA
NA
1
61
RSV indicates respiratory syncytial virus; hMPV, human metapeumovirus; PIV1-3, parainfluenza virus type 1, 2, and 3; M. pneumoniae,
Mycoplasma pneumoniae; C. pneumoniae, Chlamydophila pneumoniae; HSV-1, herpes simplex virus type 1. NA; not applicable. a Viral detection rates of
viral culture compared with real-time PCR assay. There were significant differences in viral detection rates among the four virus groups (RSV, hMPV,
PIV1-3, adenovirus): P < 0.01. b Three hundred and thirty had single-pathogen infections, 73 double-pathogen infections, and 8 triple-pathogen infections,
with coinfection rate of 19.7% among the 411 children infected with any pathogen. c Patients or specimens with coinfection were counted multiple times,
once for each pathogen. d Of the 19 specimens with positive cultures, three had lower number of virus copies than cutoff value; accordingly, the number of
patients with enterovirus infection was considered to be 38.
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