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ANATOMY OF BRAINSTEM AND ASSOCIATED LESIONS - MIDBRAIN: MIDBRAIN: At the end of the lecture the student should be able to know: • External features of midbrain • Cranial Nerves of the Midbrain • Internal structure of midbrain • Lesions of midbrain MIDBRAIN: • LANDMARKS • Cerebral peduncles • Optic chiasm • Interpeduncular fossa • (Superior colliculi) • (Inferior colliculi) • (Superior cerebellar peduncle) MIDBRAIN: • Cranial Nerves III, IV • Midbrain is divided at the level of cerebral aqueduct into: • Dorsal portion called tectum which largely consists of inferior and superior colliculi • Ventral portion, known as tegmentum EXTERNAL STRUCTURE OF MIDBRAIN: 1. Optic chiasm 2. Interpeduncular fossa 3. Oculomotor nerve (CN III) 4. Trochlear nerve (CN IV) 5. Pons 6. Cerebral peduncles (crus cerebri). CRANIA NERVES OF THE MDBRAIN: • Anterior exit • CN III (1) • CN VI (5) • Posterior exit • CN IV (2) • MLF - Medial longitudinal fasciculus (7) • Vestibular nuclei (6) • Pons (3) INTERNAL DIVISIONS OF MIDBRAIN: • Tegmentum is bounded ventrally by the massive fibre system of the crus cerebri • The term cerebral peduncle is sometimes used as a synonym for crus cerebri • Cerebral peduncle refers to the whole midbrain on either side excluding the tectum. INTERNAL DIVISIONS OF MIDBRAIN: • Ventral to the colliculi the cerebral aqueduct runs the length of the midbrain • Surrounding the aqueduct is a pear shaped arrangement of grey matter called Periaqueductal grey matter. SUBSTANTIA NIGRA: • These neurons project to the caudate nucleus and putamen of the basal ganglia in the forebrain • Degeneration of the pars compacta of the substantia nigra is associated with Parkinson’s disease SUBSTANTIA NIGRA: • Other non pigmented subdivision of the substantia nigra is called the pars reticulata • Pars reticulata is considered to be a functional homologue of the medial segment of the globus pallidus which is also part of the basal ganglia. INTERNAL STRUCTURE OF MIDBRAIN: • Cross section at the level of inferior colliculus • CN IV Trochlear nerve • MLF • Dorsal raphe nucleus • Substantia nigra • Mesencephalic nucleus of V LOWER PART OF MIDBRAIN: • CAUDAL PART OF MIDBRAIN: • In the caudal part of the midbrain the inferior colliculus constitutes part of the ascending acoustic projection • Ascending auditory fibres run in the lateral lemniscus which terminates in the inferior colliculus CAUDAL PART OF MIDBRAIN: • Efferent fibres from the colliculus terminate in the medial geniculate nucleus of the thalamus • This nucleus projects to the auditory cortex of the temporal lobe. INTERNAL STRUCTURE OF MIDBRAIN: Cross section at the level of superior colliculus: • Medial geniculate body • Superior colliculus • Crus cerebri (cerebral peduncle) • Red nucleus –Controls arm movement • Substantia nigra • Upper midbrain • Cranial Nerves of Upper Midbrain ROSTRAL PART OF MIDBRAIN: • The superior colliculus of the rostral area of the midbrain is part of the visual system • Its main afferents are corticotectal fibres originating from the visual cortex of the occipital lobe and from the frontal eye field of the frontal lobe • These inputs are concerned with controlling movements of the eyes. BLOCKAGE OF CEREBRAL AQUEDUCT: • Cerebral aqueduct is one of the narrowest parts of ventricular system. • In congenital hydrocephalus, or tumors of midbrain, aqueduct may be blocked which blocks the flow of CSF.