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Table of Comparison Water-Soluble Hormones Chemical structure How transported in blood? Location of Receptor Mechanism of Cell Signaling Involves G Proteins? (Yes or No) Directly affects gene expression? (Yes or No) Involves Second Messengers? (Yes or No) T3 and T4 (Thyroxine) Insulin Cortisol Oxytocin Glucagon Testosterone Lipid-Soluble Hormones