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NB: Submission of a Complex Case and presentation at the Saturday Session at the Annual Meeting does not preclude you from submitting and presenting at the IARS or ASA Annual Meetings. All submitted cases will be considered for oral presentation. Those not selected for oral presentation will then be considered for poster presentation. Instructions for Submitting Complex Cases for oral presentation and poster presentation 1. Only cases submitted on the proper form will be considered. Cases are limited to one written page. 2. Please use the format shown on the enclosed example (see page 2 of this document). 3. Font size smaller than 10 point will not be accepted. 4. All cases must be received by December 18, 2009 at 12:00pm (ET). 5. All images need to be attached as a separate JPEG File. 6. Ensure that the Disclosure Form is completed and returned with complex case. (Only the Presenting Author needs to complete this form) 7. Complete application below. 8. Create a blinded copy on page 4. A. Copy only the Title and Case into their respective boxes. B. Leave the Author, Mentor and Affiliation lines blank 9. Save this document. 10. E-mail the file to [email protected]. Subject line should read: Complex Case Submission – Presenting Authors Last Name (i.e. – “Complex Case Submission – Smith”). If your case contains any images, please include it as a separate attachment to your email. Please make sure all figures, images, etc. are black and white. 11. These documents will be processed electronically. The blinded copy on Page 4 will be submitted to the judges. If your document does not strictly follow the proper format it will not be processed. 12. If you have not received an email receipt confirmation within two (2) working days, please notify the SCA Administrative Office at [email protected] or 804-282-0084. Case Submission Application 1. Title of Case: 2. Name of Submitting Fellow or Resident and Institution (please indicate whether you are a resident or fellow): 3. Name of faculty mentor: 4. Complete name and address of where correspondence should be sent: Address: Phone: Fax: Email: Presentations and Other Important Information: 1. All accepted cases will be presented at the 2010 Annual Meeting Session on Saturday, April 24, 2010. 2. The format for oral presentation will be PowerPoint presentation of the cases with discussion by the fellow and a panel of experts (8-10 minutes for presentation, 5-7 minutes for discussion). It is not necessary to prepare a poster. 3. Poster presentation of cases will follow the oral case presentations on Saturday, April 24, 2010. 4. If accepted, the fellow must attend the Annual Meeting to present the case. Registration fees are NOT waived. 5. Please remember to sign the bottom of page 7 and complete the COI Disclosure. 6. Applicants must be members of the SCA. The Successful Avoidance of Catecholamines Despite Severe Biventricular Dysfunction in a Patient Undergoing Multivalve Surgery For Carcinoid Syndrome Author: Mickey Mouse, MD (Fellow) Faculty Mentor: Donald Duck, MD Affiliation: Magic Kingdom School of Medicine Introduction: Though recent literature suggests that the perioperative use of catecholamines in conjunction with octreotide in patients with carcinoid heart disease may not be contraindicated, 1 their safety has not been unequivocally demonstrated. We present a case of severe biventricular dysfunction following multiple valve surgery in a patient with severe carcinoid syndrome where an alternative management strategy was successfully employed to avoid the issue entirely. Case Presentation: A 61 yr old male with widely metastatic carcinoid disease and carcinoid syndrome presented for tricuspid and pulmonic valve replacements and mitral annuloplasty. Preoperative cardiac workup revealed global hypokinesis of the left ventricle (EF approximately 20%), a dilated but normally functioning right ventricle, severe tricuspid and pulmonic regurgitation, moderate mitral regurgitation and mild aortic regurgitation. Carcinoid symptomatology was controlled perioperatively with a continuous intravenous infusion of octreotide (100 mcg/hr). Following placement of a radial arterial pressure monitoring cannula and a central venous access, anesthesia was induced with midazolam, etomidate, fentanyl and vecuronium. Aminocaproic acid was used as the antifibrinolytic agent. No carcinoid crises were observed in the pre-bypass period. Cardiopulmonary bypass (CPB) lasted for approximately four hours. Severe biventricular dysfunction was evident once the aortic cross-clamp was removed. A milrinone load (50 mcg/kg) was slowly administered while still on CPB. The patient was separated from CPB with the assistance of inhaled epoprostenol (12.5 mcg/kg/min), vasopressin (1.8 units/hr, IV), atrioventricular pacing and an intra-aortic balloon pump. At the conclusion of the case, TEE demonstrated that the prosthetic tricuspid and pulmonic valves were intact and there was no residual mitral regurgitation. Though biventricular function was moderately-severely depressed, the patient demonstrated good hemodynamic stability without the need for inotropes. The patient was extubated on the first postoperative day and the IABP removed on the second postoperative day. He was discharged from the hospital on postoperative day #9. Discussion: Traditional anesthetic management of the patient undergoing valvular surgery to address carcinoid heart disease revolved around the avoidance of inducing carcinoid crisis (e.g., hypotension and bronchospasm) by avoiding factors which would trigger release of kallikreins from the carcinoid tumor, leading to the formation of bradykinins that produce vasodilatation. Classic factors include the administration of catecholamines (e.g., epinephrine2, norepinephrine3, dopamine4, isoproteronol5), calcium6, and medications that can cause histamine release and tumor manipulation. However, the continuous administration of octreotide has become a mainstay of modern intraoperative management and is claimed to be somewhat protective against the potentially deleterious effects of catecholamine administration in this population. 1 Given that this patient’s carcinoid symptomatology was adequately controlled by his octreotide infusion, we elected to manage his severe biventricular dysfunction with selective therapies that would avoid conventional catecholamines if possible. As predicted by the principle of ventriculo-arterial coupling, reduction of the right ventricular afterload by inhaled epoprostenol allowed for adequate RV output despite poor intrinsic RV systolic mechanics. Intra-aortic balloon counterpulsation and atrioventricular pacing allowed for adequate output from the left ventricle. Vasopressin infusion was employed to provide systemic vasoconstriction without increasing pulmonary vascular resistance. Overall, this strategy proved very effective for a patient who otherwise clearly would have been placed on catecholamines to assist separation from CPB. References: 1) Anesth Analg 2007;105(5):1192-99; 2) Lancet 1959;2:715; 3) Proc R Soc Med1957;50:40; 4) Lancet 1969;2:293–7; 5) J CardiothoracAnesth 1988;2:658–65; 6) Surg Gynecol Obstet 1973;137:637–44 TITLE: AUTHOR: FACULTY MENTOR: AFFILIATION: ABSTRACT BODY: TITLE: AUTHOR: <BLINDED COPY LEAVE BLANK> FACULTY MENTOR: <BLINDED COPY LEAVE BLANK> AFFILIATION: <BLINDED COPY LEAVE BLANK> ABSTRACT BODY: Disclosure of Relevant Financial Relationships (Only Presenting Author needs to complete this form) SCA 32nd Annual Meeting & Workshops April 24-28, 2010 • New Orleans, LA Name: Content of Activity: Complex Case Presentation Date of Activity: April 24, 2010 First: List the names of proprietary entities producing health care goods and services, with the exception of non-profit or government organizations and non-health care related companies with which you or your spouse/partner have, or have had, a relevant financial relationship within the past 12 months. For this purpose we consider the relevant financial relationships of your spouse or partner that you are aware of to be yours. Second: Describe what you or your spouse/partner received (ex: salary, honorarium, etc). SCA does NOT want to know how much you received. Third: Describe your role. Nature of Relevant Financial Relationship (Include all those that apply) Commercial Interest What was received For What Role? Honorarium Speaker Example: Company ‘X’ I do not have any relevant financial relationships with any commercial interests. Signature Date Example terminology What was received: Salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Role(s): Employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and ‘other activities (please specify). Glossary of Terms Commercial Interest The ACCME defines a “commercial interest” as any proprietary entity producing health care goods or services, with the exemption of non-profit or government organizations and non-health care related companies. Financial relationships Financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received, or expected. ACCME considers relationships of the person involved in the CME activity to include financial relationships of a spouse or partner. Relevant financial relationships ACCME focuses on financial relationships with commercial interests in the 12-month period preceding the time that the individual is being asked to assume a role controlling content of the CME activity. ACCME has not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship. The ACCME defines “’relevant’ financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. Conflict of Interest Circumstances create a conflict of interest when an individual has an opportunity to affect CME content about products or services of a commercial interest with which he/she has a financial relationship. CME REQUIREMENTS The Accreditation Council for Continuing Medical Education (ACCME) accredits SCA. As such, we have made the choice to meet the ACCME’s expectations for our practice of continuing medical education. Our accreditation is important to us. We look forward to working together to provide CME at the highest standard. SCA has implemented a process where everyone who is in a position to control the content of an education activity has disclosed to us all relevant financial relationships with any commercial interest. In addition, should it be determined that a conflict of interest exists as a result of a financial relationship you may have, this will need to be resolved prior to the activity. This information is necessary in order for us to be able to move to the next steps in planning this CME activity. If you refuse to disclose relevant financial relationships, you will be disqualified from being a part of the CME activity. The Commercial Support Standards also require that your presentation is free of commercial bias and that any information regarding commercial products/services be based on scientific methods generally accepted by the medical community. When discussing therapeutic options, it is our preference that you use only generic names. If it is necessary to use a trade name, then those of several companies must be used. Further, should your presentation include discussion of any unlabeled/investigational use of a commercial product, you are required to disclose this to the participants. Should you determine that you cannot comply with these requirements or any of the provisions, please contact the SCA Administrative Office as soon as possible. It is the Society’s policy to conduct post-activity evaluations. These evaluations ask participants to indicate the appropriateness of presentations to their specific practices, if the presentations satisfied the stated objectives, if they were satisfied with the faculty presentations and if there was any evidence of commercial bias. The results of these evaluations are used to plan future CME activities and are shared with the faculty. Once again thank you for your willingness to participate in this event. We have worked hard to develop a program which will meet the expressed needs of our expected participants, who we anticipate will come from the US, Canada and overseas. A) Generic and Trade Names – Presentations must give a balanced view of therapeutic options. Presenter’s use of general names will contribute to this impartiality. If trade names are used, those of several companies should be used rather than only that of a single supporting company. B) Unlabeled Uses of Products – When an unlabeled use of a commercial product, or an investigational use not yet approved for any purpose is discussed during an educational activity, the presenter is required to disclose that the product is not labeled for the use under discussion or that the product is still investigational. My presentation will comply with sections A-B above. SIGNATURE:________________________________________ DATE:____________________ PLEASE RETURN TO THE SCA ADMINISTRATIVE OFFICE WITH YOUR CASE PRESENTATION SUBMISSION