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Supplementary Table 3. Bioinformatic analyses of the differentially-secreted proteins by various prediction softwares and database Identified protein UniProtKB accession ID Gene name SignalPa) TMHMMb) SecretomePc) Human plasma databased) Human exosome databasee) Subcellular locationsf) Thioredoxin P10599 TXN No No No Yes Yes Galectin-1 P09382 LGALS1 No No No Yes Yes Eukaryotic translation initiation factor 5A-1 P63241 EIF5A No No No Yes Yes Ferritin heavy chain P02794 FTH1 No No Yes Yes Yes Peroxiredoxin-2 P32119 PRDX2 No No Yes Yes Yes Glutathione S-transferase P P09211 GSTP1 No No Yes Yes Yes Nucleoside diphosphate kinase A P15531 NME1 No No No Yes Yes Ubiquitin carboxyl-terminal hydrolase isozyme L1 14-3-3 protein sigma P09936 UCHL1 No No Yes Yes No Cytoplasm, Extracellular, Extracellular vesicular exosome, Nucleus, Secreted Cytoplasm, Extracellular, Nucleus, Plasma membrane, Secreted Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleolus, Nucleus Cytoplasm, Extracellular vesicular exosome Cytoplasm, Extracellular vesicular exosome, Plasma membrane Cytoplasm, Extracellular vesicular exosome, Mitochondrion, Nucleus Cytoplasm, Extracellular, Mitochondrion, Nucleus, Ruffle membrane Cytoplasm, Endoplasmic reticulum, Membrane P31947 SFN No No No Yes Yes Tropomyosin alpha-4 chain Proteasome activator complex subunit 1 P67936 TPM4 No No No Yes Yes Q06323 PSME1 No No No Yes Yes Cytoplasm, Extracellular vesicular exosome, Secreted Cytoskeleton, Extracellular vesicular exosome Cytoplasm, Nucleus, Extracellular vesicular exosome Cytoskeleton, Extracellular vesicular exosome, Membrane, Mitochondrion Cytoplasm. Extracellular vesicular exosome, Plasma membrane Cytoplasm, Extracellular vesicular exosome F-actin-capping protein subunit beta P47756 CAPZB No No Yes Yes Yes Annexin A3 P12429 ANXA3 No No No Yes Yes F-actin-capping protein subunit alpha-1 L-lactate dehydrogenase B chain 40S ribosomal protein SA P52907 CAPZA1 No No No Yes Yes P07195 LDHB No No Yes Yes Yes Cytoplasm, Extracellular vesicular exosome P08865 RPSA No No Yes Yes Yes Glutaredoxin-3 Serpin B5 O76003 P36952 GLRX3 SERPINB 5 No No No No Yes No Yes Yes Yesg) No Secretogranin-3 Q8WXD2 SCG3 Yes No No Yes No RuvB-like 2 Q9Y230 RUVBL2 No No No Yes Yes T-complex protein 1 subunit epsilon P48643 CCT5 No No No Yes Yes Alpha-enolase P06733 ENO1 No No Yes Yes Yes Plasminogen activator inhibitor 1 Acetyl-CoA P05121 SERPINE 1 ACAT2 Yes No Yes Yes Yes No No Yes Yes Yes Cytoplasm, Cytosol, Extracellular vesicular exosome, Nucleolus, Plasma membrane, Ribosome Cytoplasm, Plasma membrane Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Extracellular, Plasma membrane, Secreted Extracellular, Golgi apparatus, Membrane, Secreted, Secretory granule Chromosome, Cytoplasm, Extracellular vesicular exosome, Membrane, Nucleolus, Nucleus Centrosome, Cytoplasm, Extracellular vesicular exosome Cytoplasm, Extracellular, Extracellular vesicular exosome, Nucleus, Plasma membrane Extracellular, Plasma membrane, Secreted Cytoplasm, Endoplasmic Q9BWD1 acetyltransferase, cytosolic Annexin A1 reticulum P04083 ANXA1 No No Yes Yes Yes Malate dehydrogenase, cytoplasmic Glutathione S-transferase omega-1 P40925 MDH1 No No No Yes Yes P78417 GSTO1 No No No Yes Yes GTP-binding nuclear protein Ran P62826 RAN No No Yes Yes Yes Fructose-bisphosphate aldolase A P04075 ALDOA No No Yes Yes Yes Annexin A2 P07355 ANXA2 No No Yes Yes Yes Glyceraldehyde-3-pho sphate dehydrogenase P04406 GAPDH No No No Yes Yes Peroxiredoxin-1 Q06830 PRDX1 No No Yes Yes Yes Transgelin-2 P37802 TAGLN2 No No Yes Yes Yes Cofilin-1 P23528 CFL1 No No Yes Yes Yes Cytoplasm, Extracellular vesicular exosome , Mitochondrion, Nucleus, Plasma membrane Cytoplasm, Cytosol, Extracellular vesicular exosome, Mitochondrion Cytoplasm, Extracellular vesicular exosome, Nucleus, Plasma membrane Cytoplasm, Extracellular vesicular exosome, Mitochondrion, Nucleus Cytoplasm, Cytosol, Extracellular vesicular exosome, Mitochondrion, Nucleus Apical membrane, Cytoplasm, Cytoskeleton, Endosome, Extracellular, Extracellular vesicular exosome, Nucleolus, Nucleus, Plasma membrane, Secreted Cytoplasm, Extracellular, Extracellular vesicular exosome, Membrane, Mitochondrion, Nucleolus, Nucleus Cytoplasm, Extracellular vesicular exosome, Mitochondrion, Nucleolus, Nucleus Cytoplasm, Extracellular vesicular exosome, Plasma, Pseudopodia Cytoplasm, Cytosol, Nucleoside diphosphate kinase B P22392 NME2 No No No Yes Yes Endoplasmin P14625 HSP90B1 Yes No No Yes Yes Extracellular, Extracellular vesicular exosome, Microsome, Mitochondrion, Nucleus, Plasma membrane Cytoplasm, Extracellular vesicular exosome, Intermediate filament, Microtubule, Mitochondrion, Nucleus, Plasma membrane Cytosol, Endoplasmic reticulum, Extracellular vesicular exosome, Mitochondrion, Plasma membrane a) Results of SignalP software prediction. Yes represented signal peptide probability ≧ 0.45, and No represented < 0.45. b) Results of TMHMM software prediction. Yes represented sequence number of predicted TMHs ≧ 1, and No represented 0. c) Results of SecretomeP software prediction. Yes represented NN-score ≧ 0.5, and No represented < 0.5. d) Plasma proteome database. Yes represented identified protein exists in database and No represented not. e) Human exosome database of ExoCarta. Yes represented identified protein exists in database and No represented not. f) Subcellular locations of identified proteins classified by Gene Ontology database. g) Identified protein exists in database for Rattus norvegicus.
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