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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BANGALORE. ANNEXURE – II APPLICATION FOR REGISTRATION OF SUBJECTS FOR DISSERTATION 1 NAME OF THE Dr. MUTTURAJ. B. HOOGAR CANDIDATE AND ADDRESS PRESENT ADDRESS: A.M.SHAIKH HOMOEOPATHIC MEDICAL COLLEGE, HOSPITAL AND P.G.RESEARCH CENTRE, NEHRU NAGAR, BELGAUM – 10 PERMANENT ADDRESS. 2 NAME OF THE DR.M. B. HOOGAR. NEAR GOVT HOSPITAL, A/P-NOGANIHAL TQ-HUKKERI- 591309, DIST – BELGAUM – 10 A.M.SHAIKH HOMOEOPATHIC INSTITUTION MEDICAL COLLEGE, HOSPITAL AND P.G.RESEARCH CENTRE, NEHRU NAGAR, BELGAUM – 10 3 COURSE OF THE STUDY DOCTOR OF MEDICINE & SUBJECT (HOMOEOPATHY) REPERTORY 4 DATE OF ADMISSION 10-06-2011 TO THE COURSE 5 TITLE OF THE TOPIC ROLE OF KENT’S REPERTORY IN THE MANAGEMENT OF “NOCTURNAL ENURESIS” – UNDERSTANDING ITS EFFECTIVENESS THROUGH CLINICAL TRIAL. 1 6. BRIEF RESUME OF THE INTENDED WORK 6.1. NEED FOR THE STUDY – Enuresis is defined as normal nearly complete evacuation of the bladder at a wrong place and time at least twice a month after the 5th year of life. Bed wetting at night is known as nocturnal enuresis. Although evacuation up to 5 year a common phenomenon. It is accompanied by or which can cause distress and anxiety to the child & parents. More than 85% children will have complete diurnal & nocturnal control by 5 years of age. The remaining 15% get continence at the rate of approximately 15% per year. By adolescence 0.5 – 1% children continue to have enuresis. CURRENT SCIENARIO: The recent studies have shown that, the spontaneous resolution of nocturnal enuresis occurs at the rate of 15% per annum4. In these days of globalization & result oriented competitive life these problems put children on psychological distress & discomfort; it is responsible for highest incidence of absenteeism resulting in loss of overall growth of children life & anxiety about their children in parents. SCOPE : The current study has prepared to study the effectiveness of homoeopathic medicines in the treatment of nocturnal enuresis because it is only through Homoeopathic case taking the set of most distinct, individual symptoms are obtained which are truly characteristic of the patient forming the basis of prescription which eventually lead to cure. In conventional system of medicine to treat nocturnal enuresis, the children are put either on antidepressants or on hormone therapy, antidiuretic drugs. But these therapies do not give permanent relief, always & affect the normal physiological functions of the body, thus adding enormous side effects in the patient. 2 Homoeopathy being therapeutic science manages each case on the virtue of individualization. The individual suffering from nocturnal enuresis is alone treated without disturbing the physiological functions. Experimental hypothesis : Homoeopathic medicines employed on the basis of constitutional approach are effective in treating nocturnal enuresis. 6.2. REVIEW OF LITERATURE – Nocturnal Enuresis can be defined as the involuntary voiding of urine at night, in a child over 5 years of age without structural & neurological disease of the bladder & urinary tract.1 Nocturnal enuresis which can cause much distress and anxiety to child & parents.1 Causes : Nocturnal enuresis may be Primary or Secondary i) PRIMARY (IDIOPATHIC) NOCTURNAL ENURESIS2 This is defined as repeated passage of urine at night, at least twice a week, for at least three consecutive months.2 This can affect 10% of 7 years old children. - This is three times more common in boys. - There is usually family history in close relatives. - Recent genetic studies in familial nocturnal enuresis have located two marker known as ENUR1, which flank the enuresis gene on chromosome 13 (Eiberg et al 1995). - It is related to sleep disorders, genetic & Psychological causes. - Reduced nocturnal ADH secretion. - Less than 3% causes have organic etiology such as obstructive uropathy and UTI. 3 ii) SECONDARY ENURESIS2 – Child has been dry for several months & again starts bedwetting. In such cases look for underlying causes – - Too enthusiastic & immature toilet training can result in secondary enuresis. - Other causes include emotional stress, Parent child maladjustment, UTI, Diabetes mellitus, Diabetes incipedus2. Dr. J. T. Kent has described same useful constitutional remedies for treatment of nocturnal enuresis namely Apis, Arn, Ars, Benz. acid, Caustic, Kreos, Nit. acid, Sep, Silica, Sulph etc. Related rubrics found Kent’s Repertory : Chapter – Urinary Organs Rubric – Urination Sub rubric – Involuntary - at night Rubric – Bladder Sub rubric – Inactivity 5 6.3. AIMS AND OBJECTIVES OF STUDY : 1) To study the mode of presentation of nocturnal enuresis in clinical practice. 2) To study the constitutional approach in the management of nocturnal enuresis. 4 7. MATERIALS AND METHODS: 7.1. SOURCE OF DATA : The subjects for this study will be taken from OPD’s/IPD’s, satellite OPD’s of A.M. Shaikh Homoeopathic Medical College Hospital & PG center Belgaum & Village health camps. 7.2. METHOD OF COLLECTION OF DATA (INCLUDING SAMPLING PROCEDURES IF ANY): Study Design – Prospective study of randomized clinical trial. Sample Size – Minimum 30 in number. Participant Subjects - Both male & female subjects of age groups 3-12 years, irrespective their of socioeconomic ground. Selection Criteria – On the basis of inclusion & exclusion Criteria, history. Sample Method – Simple randomized sampling procedure will be adopted. Duration of Study – All the cases of nocturnal enuresis are registered between 10th May 2012 to 30th August 2013 will be selected for the study. Follow up – Follow up of every case will be done at every month up to 9 months to assess the prognosis. FOLLOWING IS THE INCLUSION CRITERIA FIXED FOR THE STUDY : Children with emotional stress, parent child maladjustment, psychological causes. All subjects will be selected based on clinical presentation. FOLLOWING IS THE EXCLUSION CRITERIA FIXED FOR THE STUDY : 1. Cases which have organic etiology such as obstructive uropathy or urinary treat infection, urethral stricture. 2. Cases having delay in neurological maturation to control bladder splinter associated – mental retardation or spinal cord abnormalities. 5 RESULT CRITERIA : Recovered Improved Not improved 7.3. DOES THE STUDY REQUIRE ANY INVESTIGATIONS OR INTERVENTION TO BE CONDUCTED ON PATIENTS OR OTHER HUMAN OR ANIMALS? IF SO PLEASE DESCRIBE BRIEFLY - Investigations will be done as per requirement of the case. - Blood investigation – ESR, Blood sugar if needed. - Urine for routine, microscopy. 7.4. HAS ETHICAL CLEARANCE HAS BEEN OBTAINED FROM YOUR INSTITUTION IN CASE OF 7.3? Yes ethical clearance has been obtained from institution. 6 8. LIST OF REFERENCES : 1. Neil McIntosh Forfar and Arnel’s “TEXT BOOK OF PEDIATRICS” published in UK, in 1998. 5th edition, pp957. 2. GHAI O.P. “GHAI ESSENTIAL PEDIATRICS” published at Delhi in 1992, 6 th edition, pp-61. 3. NELSON’s “TEXT BOOK OF PEDIATRICS” pulished in Bangalore in 1996, 15th edition pp-1544. 4. http://en.wikipedia.org/wiki/nocturnal enuresis. 28/02/2012 5. KENT J.T.’s Repertory of Homoeopathic Materia Medica by J.T.KENT published in New Delhi, in 1935. Indian 4th edition pp-659. 7 9. SIGNATURE OF CANDIDATE 10. REMARKS OF THE GUIDE 11. NAME AND DESIGNATION OF 11.1 GUIDE Dr. S. S. PUJAR M.D. (Hom.) Professor and Guide. HOD Department of Repertory, A.M.Shaikh Homoeopathic Medical College, Hospital & Post Graduate research center Nehru Nagar, Belgum-10 11.2 SIGNATURE 11.3 CO-GUIDE (IF ANY) ------- 11.4 SIGNATURE ……. 11.5 HEAD OF DEPARTMENT Dr. S. S. PUJAR M.D.(Hom.) Professor, Guide and HOD. Department of Repertory, A.M.Shaikh Homoeopathic Medical College, Hospital & Post Graduate research center Nehru Nagar, Belgaum-10 11.6 SIGNATURE 12. 12.1 REMARKS OF CHAIRMAN AND PRINCIPAL 12.2 SIGNATURE 8