Download 402_05_ps4

MEDCH402
Fall 2005
Problem Set #4
I.
Match the vitamin or mineral with the corresponding amount and unit.
Vitamin/Mineral
1) Vitamin D
2) Thiamin
3) Biotin
4) Vitamin A
5) Folacin
6) Vitamin E
7) Niacin
8) Pantothenic Acid
9) Vitamin C
10) Vitamin B6
11) Vitamin B12
12) Riboflavin
II.
Increased urinary xanthurenic acid
Increased plasma pyruvate
Increased plasma homocysteine
Decreased erythrocyte glutathione reductase activity
List the vitamins associated with the following functions.
a)
b)
c)
d)
e)
IV.
Unit
x) mg
y) g
z) IU
The following are signs of a vitamin deficiency. List the most appropriate single deficient
vitamin for each.
a)
b)
c)
d)
III.
Amount
a) 20
b) 0.3
c) 5000
d) 400
e) 6
f) 60
g) 10
h) 1.5
i) 30
j) 1.7
k) 0.4
l) 2
Decarboxylation
Transamination
Purine and pyrimidine synthesis
Electron transport
Niacin synthesis
For the following conditions, name the vitamin that has been shown to be of some benefit
and what enzyme/reaction is activated by high doses of that vitamin.
a)
b)
c)
d)
Homocysteineurea
Wernicke-Korsakoff syndrome
Methylmalonic acidurea
Xanthuronic acidurea
V.
Why is it important that a woman who is pregnant or is planning on becoming pregnant
should be receiving supplemental folate?
VI.
Why does folic acid require a prescription for high doses even though it is essentially
nontoxic?
VII.
L-Dopa is used in the treatment of Parkinson’s disease. Why is vitamin B6 contraindicated
for patients using L-Dopa and why is Carbi-Dopa often used in combination with L-Dopa?
VIII.
Provide a metabolic explanation for the following scenarios (schemes, not structures may
be necessary for a complete answer).
a) A folate deficiency is observed during a vitamin B12 deficiency.
b) Homocysteine levels may be elevated if vitamin B6 intake is inadequate.
c) Niacin may be deficient if B6 intake is inadequate.
IX.
Suggest the vitamin antagonized and one symptom that you might expect with chronic
administration of the following vitamin antagonist listed below.
a)
NH2
+
N
N
H3C
N
H3C
S
OH
b)
CH3
HO
H3C
OH
N
c)
O
CH3
N
N
H3C
N
N
O
N
H
N
CH3
OH
O
OH