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Table S4. Functional annotation of genes that are significantly up-regulated by vitamin C for at
least 1.5 folds in immortalized mouse embryonic fibroblasts
Enrichment of genes in cell cycle functional category
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
aryl-hydrocarbon receptor
asp (abnormal spindle)-like, microcephaly associated
aurora kinase A
breast cancer 2
budding uninhibited by benzimidazoles 1 homolog
budding uninhibited by benzimidazoles 1 homolog, beta
cell division cycle 25 homolog A
cell division cycle 25 homolog B
cell division cycle 25 homolog C
cell division cycle 45 homolog-like
cell division cycle 6 homolog
cell division cycle associated 2
cell division cycle associated 3
cell division cycle associated 5
cell division cycle associated 8
centromere protein E
centrosomal protein 55
checkpoint kinase 1 homolog
chromatin assembly factor 1, subunit A (p150)
chromatin assembly factor 1, subunit B (p60)
claspin homolog
CLIP associating protein 1
coiled-coil domain containing 99
CTF18, chromosome transmission fidelity factor 18 homolog
cyclin A1
cyclin A2
cyclin B1
cyclin D1
cyclin F
cyclin-dependent kinase 6
cyclin-dependent kinase inhibitor 3
DBF4 homolog
DnaJ (Hsp40) homolog, subfamily C, member 2
discs, large (Drosophila) homolog-associated protein 5
E2F transcription factor 2
establishment of cohesion 1 homolog 2
excision repair cross-complementing rodent repair deficiency
complementation group 6 - like
extra spindle poles-like 1
Fanconi anemia, complementation group A
fold
1.5
1.9
2.1
1.9
1.5
1.9
1.8
1.7
1.5
1.9
1.7
1.7
1.8
1.8
1.8
1.8
1.9
1.9
1.7
2.0
2.1
1.7
1.5
1.8
2.1
1.6
1.6
1.8
1.9
1.8
1.7
1.6
1.8
2.0
1.7
1.7
1.6
1.5
p
0.005
0.006
0.005
0.004
0.004
0.001
0.0005
0.005
0.006
0.0008
9.6E-05
0.002
0.001
0.009
0.006
0.002
0.002
0.006
0.004
0.003
0.004
0.007
0.004
0.004
0.006
0.009
0.008
0.008
0.003
0.0008
0.0002
0.003
0.007
0.003
0.0002
0.005
0.0008
0.008
2.2
1.9
0.002
0.004
Fanconi anemia, complementation group D2
helicase, lymphoid specific
high mobility group AT-hook 2
inner centromere protein
kinesin family member 11
kinesin family member 18A
kinetochore associated 1
Mdm2, transformed 3T3 cell double minute p53 binding protein
meiosis-specific nuclear structural protein 1
minichromosome maintenance deficient 2 mitotin
minichromosome maintenance deficient 3
minichromosome maintenance deficient 7
minichromosome maintenance deficient 8
mitogen-activated protein kinase 4
NIMA (never in mitosis gene a)-related expressed kinase 2
nuclear autoantigenic sperm protein (histone-binding)
nuclear distribution gene C homolog
par-6 (partitioning defective 6) homolog beta
3-phosphoglycerate dehydrogenase
polo-like kinase 1
polymerase (DNA directed), alpha 1
proteasome 26S subunit, ATPase 3, interacting protein
protein kinase, membrane associated tyrosine/threonine 1
RAD51 homolog
regulator of chromosome condensation 1
regulator of chromosome condensation 2
replication protein A1
ribosomal protein S6 kinase, polypeptide 2
Rap1 interacting factor 1 homolog (yeast)
septin 3
SET domain containing (lysine methyltransferase) 8
shugoshin-like 1
sperm associated antigen 5
spindle assembly 6 homolog
stathmin 1
structural maintenance of chromosomes 2
SUMO/sentrin specific peptidase 5
suppressor of variegation 3-9 homolog 1
suppressor of variegation 3-9 homolog 2
timeless homolog
TPX2, microtubule-associated protein homolog
ubiquitin-like, containing PHD and RING finger domains, 1
vomeronasal 2, receptor 53
ZW10 interactor
1.7
1.8
2.1
1.7
2.2
1.8
1.8
2.1
2.2
1.7
2.0
1.6
1.5
2.8
2.0
2.3
1.6
1.7
2.6
1.6
1.8
1.8
1.6
1.6
2.0
1.6
1.6
1.8
1.7
3.3
1.6
1.7
1.8
1.7
1.8
2.2
1.7
1.5
2.2
1.7
1.6
1.6
1.8
1.7
0.003
0.006
0.002
0.0008
0.006
0.0004
0.0002
0.002
0.008
0.0005
0.001
0.0008
0.002
0.008
0.003
0.003
0.006
0.005
0.001
0.004
0.003
0.002
0.009
0.008
0.001
0.008
0.001
0.001
0.0003
0.004
0.0001
0.003
0.001
0.006
1.004
0.007
0.002
0.0003
0.007
6.8E-05
0.002
0.009
0.0005
0.006
Enrichment of genes in cell division functional category
asp (abnormal spindle)-like, microcephaly associated
breast cancer 2
budding uninhibited by benzimidazoles 1 homolog
budding uninhibited by benzimidazoles 1 homolog, beta
cell division cycle 25 homolog A
cell division cycle 25 homolog B
cell division cycle 25 homolog C
cell division cycle 45 homolog-like
cell division cycle 6 homolog
cell division cycle associated 2
cell division cycle associated 3
cell division cycle associated 5
cell division cycle associated 7
cell division cycle associated 8
centromere protein E
centrosomal protein 55
CLIP associating protein 1
coiled-coil domain containing 99
cyclin A1
cyclin A2
cyclin B1
cyclin D1
cyclin F
cyclin-dependent kinase 6
excision repair cross-complementing rodent repair deficiency,
complementation group 6 - like
excision repair cross-complementing rodent repair deficiency,
complementation group 2
helicase, lymphoid specific
high mobility group AT-hook 2
inner centromere protein
kinesin family member 11
kinetochore associated 1
minichromosome maintenance deficient 5, cell division cycle 46
NIMA (never in mitosis gene a)-related expressed kinase 2
nuclear distribution gene C homolog
par-6 (partitioning defective 6) homolog beta
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
polo-like kinase 1
regulator of chromosome condensation 1
regulator of chromosome condensation 2
SET domain containing (lysine methyltransferase) 8
shugoshin-like 1
sperm associated antigen 5
fold
2.1
1.5
1.9
1.8
1.7
1.5
1.9
1.7
1.7
1.7
1.8
1.8
2.0
1.9
1.9
1.9
1.6
1.8
1.7
1.6
1.8
1.9
1.8
1.7
1.8
p
0.005
0.004
0.001
0.0006
0.005
0.006
0.0008
9.6E-05
0.002
0.004
0.009
0.002
0.005
0.002
0.002
0.006
0.003
0.0009
0.009
0.008
0.008
0.001
0.0008
0.0002
0.0001
1.5
0.002
1.8
1.9
1.7
2.2
1.8
1.9
2.0
1.6
1.7
1.7
1.6
2.0
1.6
1.6
1.7
1.8
0.006
0.0008
0.0008
0.006
0.0002
0.0002
0.003
0.006
0.005
0.003
0.004
0.001
0.008
0.0001
0.003
0.001
structural maintenance of chromosomes 2
SUMO/sentrin specific peptidase 5
timeless homolog
topoisomerase (DNA) II alpha
vomeronasal 2, receptor 53
ZW10 interactor
2.2
1.7
1.7
2.1
1.8
1.7
0.007
0.002
6.8E-05
0.0008
0.0005
0.006
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