Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Table S4. Functional annotation of genes that are significantly up-regulated by vitamin C for at least 1.5 folds in immortalized mouse embryonic fibroblasts Enrichment of genes in cell cycle functional category acidic (leucine-rich) nuclear phosphoprotein 32 family, member B aryl-hydrocarbon receptor asp (abnormal spindle)-like, microcephaly associated aurora kinase A breast cancer 2 budding uninhibited by benzimidazoles 1 homolog budding uninhibited by benzimidazoles 1 homolog, beta cell division cycle 25 homolog A cell division cycle 25 homolog B cell division cycle 25 homolog C cell division cycle 45 homolog-like cell division cycle 6 homolog cell division cycle associated 2 cell division cycle associated 3 cell division cycle associated 5 cell division cycle associated 8 centromere protein E centrosomal protein 55 checkpoint kinase 1 homolog chromatin assembly factor 1, subunit A (p150) chromatin assembly factor 1, subunit B (p60) claspin homolog CLIP associating protein 1 coiled-coil domain containing 99 CTF18, chromosome transmission fidelity factor 18 homolog cyclin A1 cyclin A2 cyclin B1 cyclin D1 cyclin F cyclin-dependent kinase 6 cyclin-dependent kinase inhibitor 3 DBF4 homolog DnaJ (Hsp40) homolog, subfamily C, member 2 discs, large (Drosophila) homolog-associated protein 5 E2F transcription factor 2 establishment of cohesion 1 homolog 2 excision repair cross-complementing rodent repair deficiency complementation group 6 - like extra spindle poles-like 1 Fanconi anemia, complementation group A fold 1.5 1.9 2.1 1.9 1.5 1.9 1.8 1.7 1.5 1.9 1.7 1.7 1.8 1.8 1.8 1.8 1.9 1.9 1.7 2.0 2.1 1.7 1.5 1.8 2.1 1.6 1.6 1.8 1.9 1.8 1.7 1.6 1.8 2.0 1.7 1.7 1.6 1.5 p 0.005 0.006 0.005 0.004 0.004 0.001 0.0005 0.005 0.006 0.0008 9.6E-05 0.002 0.001 0.009 0.006 0.002 0.002 0.006 0.004 0.003 0.004 0.007 0.004 0.004 0.006 0.009 0.008 0.008 0.003 0.0008 0.0002 0.003 0.007 0.003 0.0002 0.005 0.0008 0.008 2.2 1.9 0.002 0.004 Fanconi anemia, complementation group D2 helicase, lymphoid specific high mobility group AT-hook 2 inner centromere protein kinesin family member 11 kinesin family member 18A kinetochore associated 1 Mdm2, transformed 3T3 cell double minute p53 binding protein meiosis-specific nuclear structural protein 1 minichromosome maintenance deficient 2 mitotin minichromosome maintenance deficient 3 minichromosome maintenance deficient 7 minichromosome maintenance deficient 8 mitogen-activated protein kinase 4 NIMA (never in mitosis gene a)-related expressed kinase 2 nuclear autoantigenic sperm protein (histone-binding) nuclear distribution gene C homolog par-6 (partitioning defective 6) homolog beta 3-phosphoglycerate dehydrogenase polo-like kinase 1 polymerase (DNA directed), alpha 1 proteasome 26S subunit, ATPase 3, interacting protein protein kinase, membrane associated tyrosine/threonine 1 RAD51 homolog regulator of chromosome condensation 1 regulator of chromosome condensation 2 replication protein A1 ribosomal protein S6 kinase, polypeptide 2 Rap1 interacting factor 1 homolog (yeast) septin 3 SET domain containing (lysine methyltransferase) 8 shugoshin-like 1 sperm associated antigen 5 spindle assembly 6 homolog stathmin 1 structural maintenance of chromosomes 2 SUMO/sentrin specific peptidase 5 suppressor of variegation 3-9 homolog 1 suppressor of variegation 3-9 homolog 2 timeless homolog TPX2, microtubule-associated protein homolog ubiquitin-like, containing PHD and RING finger domains, 1 vomeronasal 2, receptor 53 ZW10 interactor 1.7 1.8 2.1 1.7 2.2 1.8 1.8 2.1 2.2 1.7 2.0 1.6 1.5 2.8 2.0 2.3 1.6 1.7 2.6 1.6 1.8 1.8 1.6 1.6 2.0 1.6 1.6 1.8 1.7 3.3 1.6 1.7 1.8 1.7 1.8 2.2 1.7 1.5 2.2 1.7 1.6 1.6 1.8 1.7 0.003 0.006 0.002 0.0008 0.006 0.0004 0.0002 0.002 0.008 0.0005 0.001 0.0008 0.002 0.008 0.003 0.003 0.006 0.005 0.001 0.004 0.003 0.002 0.009 0.008 0.001 0.008 0.001 0.001 0.0003 0.004 0.0001 0.003 0.001 0.006 1.004 0.007 0.002 0.0003 0.007 6.8E-05 0.002 0.009 0.0005 0.006 Enrichment of genes in cell division functional category asp (abnormal spindle)-like, microcephaly associated breast cancer 2 budding uninhibited by benzimidazoles 1 homolog budding uninhibited by benzimidazoles 1 homolog, beta cell division cycle 25 homolog A cell division cycle 25 homolog B cell division cycle 25 homolog C cell division cycle 45 homolog-like cell division cycle 6 homolog cell division cycle associated 2 cell division cycle associated 3 cell division cycle associated 5 cell division cycle associated 7 cell division cycle associated 8 centromere protein E centrosomal protein 55 CLIP associating protein 1 coiled-coil domain containing 99 cyclin A1 cyclin A2 cyclin B1 cyclin D1 cyclin F cyclin-dependent kinase 6 excision repair cross-complementing rodent repair deficiency, complementation group 6 - like excision repair cross-complementing rodent repair deficiency, complementation group 2 helicase, lymphoid specific high mobility group AT-hook 2 inner centromere protein kinesin family member 11 kinetochore associated 1 minichromosome maintenance deficient 5, cell division cycle 46 NIMA (never in mitosis gene a)-related expressed kinase 2 nuclear distribution gene C homolog par-6 (partitioning defective 6) homolog beta phosphatidylinositol 3-kinase, catalytic, beta polypeptide polo-like kinase 1 regulator of chromosome condensation 1 regulator of chromosome condensation 2 SET domain containing (lysine methyltransferase) 8 shugoshin-like 1 sperm associated antigen 5 fold 2.1 1.5 1.9 1.8 1.7 1.5 1.9 1.7 1.7 1.7 1.8 1.8 2.0 1.9 1.9 1.9 1.6 1.8 1.7 1.6 1.8 1.9 1.8 1.7 1.8 p 0.005 0.004 0.001 0.0006 0.005 0.006 0.0008 9.6E-05 0.002 0.004 0.009 0.002 0.005 0.002 0.002 0.006 0.003 0.0009 0.009 0.008 0.008 0.001 0.0008 0.0002 0.0001 1.5 0.002 1.8 1.9 1.7 2.2 1.8 1.9 2.0 1.6 1.7 1.7 1.6 2.0 1.6 1.6 1.7 1.8 0.006 0.0008 0.0008 0.006 0.0002 0.0002 0.003 0.006 0.005 0.003 0.004 0.001 0.008 0.0001 0.003 0.001 structural maintenance of chromosomes 2 SUMO/sentrin specific peptidase 5 timeless homolog topoisomerase (DNA) II alpha vomeronasal 2, receptor 53 ZW10 interactor 2.2 1.7 1.7 2.1 1.8 1.7 0.007 0.002 6.8E-05 0.0008 0.0005 0.006