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Unit Six: Genetics Part One: DNA, RNA, and Protein Synthesis (Ch. 12) Part Two: Mendelian Genetics (Ch. 11) Part Three: Biotechnology (Ch. 13 & 14) Part One: DNA, RNA, and Protein Synthesis Chapter 12 (pages 286 – 308) Objectives: 1. Describe and model the structure of DNA. 2. Compare and contrast the structure and function of DNA and RNA 3. Explain the functional relationships between DNA, genes, alleles, and chromosomes….and their roles in inheritance. 4. Describe how the process of DNA replication results in the transmission and/or conservation of genetic information. 5. Explain the steps of the process of transcription 6. Model the steps of the process of translation (protein synthesis) 7. Describe processes that can alter the composition…of chromosomes (duplication, translocation, deletion, insertion, and inversion.) 8. Describe how genetic mutations alter the DNA sequence and may or may not affect phenotype. Assessments: See the Assessment sheet on the back of this packet! Vocabulary: Transformation Deoxyribonucleic Acid Nucleotide Base paring Chromosomes Chromatin Histone DNA replication Semiconservative replication DNA polymerase Gene RNA polymerase Messenger RNA Ribosomal RNA Transfer RNA Transcription Codon Translation (Protein synthesis) Ribosome Anticodon Mutation Frame shift mutation Point mutation DF 1 DNA Structure and Function Stands for: Function: Structure: Individual units are called: Three parts: 1) 2) 3) - - - - Scientific Discoveries: Frederick Griffith (1928) Transformation Erwin Chargaff (1952) Rosalind Franklin & Maurice Wilkins (1952) James Watson and Francis Crick (1953) The “Double Helix” structure of DNA Semiconservative replication How is DNA different in different organisms? DF 2 DNA Replication What? Why? When? Where? Who? (The enzymes involved…) - DNA Polymerase - DNA Helicase How? 1) 2) 3) 4) 5) The result? Mistakes = Error Rate: How is replication different in different organisms? DF 3 RNA Structure and Function Stands for: Function: Structure: Individual units are called: Three parts: 1) 2) 3) - - - - Three Types of RNA: 1) 2) 3) Differences: RNA DNA What RNA looks like: DF 4 Transcription What? Why? When? Where? Who? (the enzyme involved) RNA Polymerase How? 1) 2) 3) 4) How Much DNA is Transcribed? Example problems: DNA= ATCTAGCA DNA= DNA= ATCCGGAA RNA= DNA= AATTGGCC RNA= RNA= ACGUAAUC DNA= How is transcription different in different organisms? DF 5 Translation What? Why? When? Where? Who? (the molecules involved) - - - - How? 1) 2) 3) 4) 5) 6) 7) There are THREE letters per codon = ________ possible combinations There are 20 amino acids. So: DNA = RNA = CCCAAATTTGGG AUGCAUUUGUAA Amino Acids = How is transcription different in different organisms? DF 6 Unit Six: Genetics Part One: DNA, RNA & Protein Synthesis Name: ___________________________________ Mr. DePhillips DNA, RNA, & Protein Synthesis Assessments Vocabulary Everyone must take the Root Word Pre-Quiz 10 pts ________ pts Activities Complete the “DNA Isolation” Lab 10 pts ________ pts Complete “How Does DNA Fit…?” Lab 20 pts ________ pts Complete the “Mutations” question sheet 20 pts ________ pts Peer-Assessment Complete the “DNA Scavenger Hunt” 20 pts ________ pts Self-Assessment Protein Synthesis Project 50 pts ________ pts Bonus: Create a Code ATB Activity Bonus: “The Real Jurassic Park” Video (after school) Journal/At the Bell assignments (~15 days) up to +10 pts up to +30 pts ~45 pts (subject to change) Review Problem Review Worksheet Other reviews will be assigned as needed…and as time permits. Test Everyone must take a Keystone-based Exam ________ pts DF 7