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Supporting Information Table S1. Functional classification of up-regulated serum proteins between the tuberculosis group and the
control group quantified by iTRAQ-based proteomics.
TB/Control-run1
Protein
Gene
ID
symbol
No.
Protein name
Biological process
TB/Control-run2
of
iTRAQ
No.
iTRAQ
peptides
ratio
peptides
ratio
(>95%)
(>95%)
Catalytic activity
Peptidyl-prolyl
P62937
cis-trans
PPIA
immune system process
1.63
4
2.19
2
response to stimulus
1.57
8
2.21
9
isomerase A
Mannan-binding lectin serine
O00187
MASP2
of
protease 2
P12955
PEPD
Xaa-Pro dipeptidase
metabolic process
2.23
7
4.92
8
P00488
F13A
Coagulation factor XIII A chain
Complement and coagulation cascades
1.31
12
1.53
12
P07195
LDHB
L-lactate dehydrogenase B chain
Propanoate metabolism
1.29
5
1.71
6
Q14520
HABP2
Hyaluronan-binding protein 2
biological adhesion
3.22
10
3.13
10
P00918
CAH2
Carbonic anhydrase 2
Collecting duct acid secretion
1.63
3
1.82
4
P00738
HPT
P08195
4F2
Haptoglobin
response to stimulus
4.29
286
99.08
254
immune system process
1.66
3
1.28
3
response to stimulus
2.01
6
2.03
6
4F2 cell-surface antigen heavy
chain
Extracellular
P08294
superoxide
SODE
dismutase [Cu-Zn]
Binding activity
O00151
PDLI1
PDZ and LIM domain protein 1
response to stimulus
1.50
5
1.98
7
P04003
C4BPA
C4b-binding protein alpha chain
Complement and coagulation cascades
3.84
37
4.17
32
Monocyte
Toll-like receptor signaling pathway; Phagosome;
P08571
CD14
2.11
19
2.40
21
differentiation
antigen CD14
Tuberculosis.
P02735
SAA
Serum amyloid A protein
immune system process
5.92
38
4.97
30
P01880
IGHD
Ig delta chain C region
immune system process
7.38
6
6.92
8
P01871
IGHM
Ig mu chain C region
immune system process
1.51
20
2.75
17
P04278
SHBG
Sex hormone-binding globulin
establishment of localization
2.91
33
2.78
32
Q15942
ZYX
Zyxin
Focal adhesion; immune system process
1.77
4
2.96
3
P04275
VWF
von Willebrand factor
1.38
47
1.79
47
ECM-receptor
interaction;
coagulation cascades
Complement
and
P21333
FLNA
Filamin-A
MAPK signaling pathway; Focal adhesion
2.68
6
2.61
4
P37802
TAGL2
Transgelin-2
developmental process
2.05
11
2.99
11
Q15485
FCN2
Ficolin-2
immune system process
3.77
10
2.42
12
P02042
HBD
Hemoglobin subunit delta
biological regulation
2.05
42
1.64
36
P18065
IBP2
biological regulation
2.88
6
1.41
5
Insulin-like
growth
factor-binding protein 2
P68871
HBB
Hemoglobin subunit beta
response to stimulus
6.55
55
99.08
50
Q9HCN6
GPVI
Platelet glycoprotein VI
ECM-receptor interaction; response to stimulus
1.56
2
1.63
2
Q9Y4L1
HYOU1
Hypoxia up-regulated protein 1
Protein processing in endoplasmic reticulum
2.23
4
1.72
5
P02766
TTHY
Transthyretin
establishment of localization
6.37
4
5.97
5
P69905
HBA
Hemoglobin subunit alpha
response to stimulus
8.55
18
6.92
14
Q9Y490
TLN1
Talin-1
Focal adhesion; response to stimulus
1.67
10
1.58
12
P61916
NPC2
Epididymal secretory protein E1
Lysosome; response to stimulus
1.84
1
1.79
1
P24821
TENA
Tenascin
ECM-receptor interaction; Focal adhesion
1.92
18
2.03
12
Q86YW5
TRML1
Trem-like transcript 1 protein
immune system process
3.08
4
1.42
2
P05556
ITB1
Integrin beta-1
Phagosome; Leukocyte transendothelial migration
1.29
1
1.28
2
P00738
HPT
Haptoglobin
response to stimulus
4.29
286
99.08
254
Q9Y6R7
FCGBP
IgGFc-binding protein
P07737
PROF1
Profilin-1
1.77
26
2.29
30
2.83
7
2.07
5
6.61
10
8.32
12
establishment of localization; Regulation of actin
cytoskeleton
response to stimulus; Complement and coagulation
P02675
FIBB
Fibrinogen beta chain
cascades
P27797
CALR
Calreticulin
Phagosome; Antigen processing and presentation
1.31
1
1.36
1
P01033
TIMP1
Metalloproteinase inhibitor 1
establishment of localization
1.57
1
1.64
1
CD5 antigen-like
response to stimulus
2.42
12
2.23
14
reproductive process
1.47
81
1.27
77
Receptor activity
O43866
CD5L
Enzyme regulator activity
P20742
PZP
Pregnancy zone protein