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Supplementary Table 2. Amino acid substitutions specific to the prairie vole lineage Protein AVP AVP AVP AVP AVP AVP AVP AVP AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AVPR1A AR AR AR AR AR AR AR AR AR AR AR AR AR AR AR AR AR AR AR Substitution T8S S38P G52D S60N S134N A136G V151L L153M G13S T22S G25D R30W G36Q E37K D39S A164T V180L A264D G266A E321D S370R S382N K411R L7P Q115H P141L E182D A224V T289A K325R G329S G333V A359V P385Q A428V G460R A473V R479H T/A485V G500T P511S Q648K Type of amino acid substitution Conservative Conservative Radical Conservative Conservative Conservative Conservative Conservative Conservative Conservative Radical Radical Conservative Radical Radical Conservative Conservative Radical Conservative Conservative Radical Conservative Conservative Conservative Radical Conservative Conservative Conservative Conservative Conservative Conservative Conservative Conservative Radical Conservative Radical Conservative Conservative Conservative Conservative Conservative Radical AR AR AR BDNF BDNF BDNF BDNF CRH CRH CRH CRHR1 CRHR1 CRHR1 CRHR1 CRHR1 CRHR2 CRHR2 CRHR2 CRHR2 CRHR2 DRD1A DRD1A DRD1A1 DRD2 ESR1 ESR1 ESR1 ESR2 ESR2 ESR2 MC4R MC4R NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 NR3C1 S657T H744Q T873A F21L E90G E91V R211K A9V V14M A131T Q14H S147N V312I R349H T383S L7P P56S A75T V263L V300I E10G G173D D184A K332R R62S E64G T216A A253T R340G S363P A27T A167G G20V Y30H V39M P46S N137K T151P E209Q L246F S264P T336A Q341E Q343P T374A S375N Conservative Radical Conservative Conservative Radical Radical Conservative Conservative Conservative Conservative Radical Conservative Conservative Conservative Conservative Conservative Conservative Conservative Conservative Conservative Radical Radical Radical Conservative Conservative Radical Conservative Conservative Radical Conservative Conservative Conservative Radical Radical Conservative Conservative Radical Conservative Conservative Conservative Conservative Conservative Conservative Radical Conservative Conservative NR3C1 G383A Conservative NR3C1 V504A Conservative NR3C1 S505A Conservative NR3C1 T557N Conservative NR3C1 G614A Conservative NR3C1 D637E Conservative NR3C1 H641Q Radical NR3C1 S761T Conservative NTRK2 L23V Conservative NTRK2 R94K Conservative NTRK2 I120V Conservative NTRK2 I144V Conservative NTRK2 S167G Conservative NTRK2 K212N Radical NTRK2 T288S Conservative OXT S56N Conservative OXT T112M Radical OXTR T66I Radical SLC6A3 R198K Conservative SLC6A3 V227I Conservative TH A72S Conservative TH R78Q Radical TH V83I Conservative TH R91K Conservative TH V150I Conservative TH A497V Conservative UCN A29V Conservative UCN A69T Conservative UCN A75G Conservative UCN F118I Conservative UCN D119H Radical UCN3 G17S Conservative UCN3 R/S19G Conservative UCN3 H24R Conservative UCN3 T38M Radical UCN3 T/S64P Conservative UCN3 S68L Radical UCN3 A/S87P Conservative UCN3 T/I96L Conservative Location is based on the prairie vole protein sequences (longest) annotated in this study. The first amino acid listed represents the inferred ancestral state and the second is the amino acid observed in the prairie vole.
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