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Supplementary MBBS II (Second) Professional Examination 2012-13 Course Code:MBS201 Paper ID:S322401 Pathology-I Time: 2 Hours 40 Minutes Max Marks: 30 Note: Attempt all questions. Draw proper diagrams to support your answer. Part ‘B’ 1. Write briefly about the role of cytokines and chemokines in acute inflammation. (7) 2. Enumerate anticipated laboratory findings in a case of severe iron deficiency anemia. Point out the differences from anemia of chronic disorder. (7) 3. Differentiate between: Necrosis and apoptosis Exudate and transudate (4+4) Write short notes on: a) Fate of thrombus b) Primary complex c) Turner’s syndrome d) Type IV hypersensitivity reaction (2x4=8) a) b) 4. Supplementary MBBS II (Second) Professional Examination 2012-13 Roll No. Student’s Name Student’s Signature Invigilator’s Signature Course Code:MBS201 Paper ID:S322401 Pathology-I Part ‘A’ Time: 20 Minutes Max Marks: 10 Note: 1. Attempt all questions and return this part of the question paper to the invigilator after 20 Minutes. 2. Please tick (√) correct one only. Cutting, overwriting or any other marking are not allowed. 3. For answering please use Ball- pen only. Q.1 Q.2 Coombs positive hemolytic anemia is associated with: a) TTP b) PAN c) SLE d) HUS (hemolytic uremic syndrome) Paraneoplastic syndrome is associated with RCC are all of the following except: a. Polycythemia b. hypercalcemia c. hypertension d. Cushing syndrome Q.3 Which of the following marker is specific for Gastrointestinal tumor (GIST): a) CD117 b) CD34 c) CD23 d) S-100 Q.4. Karyotyping is useful in diagnosis: a) Autosomal recessive disorder b) x-linked recessive disorder c) Chromosomal abnormalities d) Biochemical abnormalities Q.5 Which tumor has a viral carcinogenic agent as predisposing condition? a) Carcinoma breast b) Carcinoma prostate c) Nasopharyngeal carcinoma d) Carcinoma pancreas Q.6 Which is the iron transport protein: a) Ferritin b) Transferrin c) Hemosiderin d) Albumin Q.7 Anticoagulant used for ESR estimation by Westergren method is: a) Double oxalate b) Heparin c) Trisodium citrate d) Flouride Q.8 The following marker is also known as Leucocyte common antigen a) CD10 b) CD15 c) CD30 d) CD45 Q.9 Specific diagnostic test in DIC is: a) Prothrombin time b) D-Dimer assay c) Factor IX assay d) APTT Q.10 The HIV virus infects ………lymphocytes: a) B lymphocytes b) Suppressor T lymphocytes c) Helper T lymphocytes d) Cytotoxic hydrostatic pressure the P.T.O Q.11 Multiple myeloma shows all the features except: a) Russel bodies b) Dutcher bodies c) Councilman bodies d Mott cells and flame cells Q.19 Q.12 Brown induration is seen in: a) Pneumonia b) Asbestosis c) Tuberculosis d) Chronic venous congestion Q.20 Q.13 Bite cells are seen in: a) Microangiopathic hemolytic anemia b) G6PD deficiency c) Paroxysmal nocturnal hemoglobinuria d) Hemolytic disease of neworn Q.14 Starry sky appearance is seen in: a) Hodgkin lymphoma b) Burkitt lymphoma c) Multiple myeloma d) Follicular lymphoma Q.15 All vitamins shows antioxidant effect except: a) Vitamin A b) Vitamin K c) Vitamin C d) Vitamin E Q.16 Hematoxylin bodies seen in: a) SLE b) PAN c) Rheumatoid orthritis d) Wegeners granulomatosus Q.17 Which of the following is the most commonly used ‘fixative’ in diagnostic pathology: a) Formaldehyde b) Ethyl alcohol c) Mercuric chloride d) Picric acid Q.18 The characteristic feature of apoptosis on light microscopy is: a) Cellular swelling b) Nuclear contraction c) Intact cell membrane d) Cytoplasmic eosinophilia Action of Bradykinin following, except: a) vasodilatation b) c) d) include all of the Bronchodilation Increased vascular permeability Pain Burkitt’s lymphoma is associated with: a) t(8:14) b) t(11:14) c) t(15:17) d) t(14:18)