Download Additional File 8

Additional File 8: Helminth secretome database (HSD): a collection of helminth excretory/secretory proteins predicted from expressed sequence tags
(ESTs)
Gagan Garg and Shoba Ranganathan
Table S8- Predicted therapeutic targets from predicted ES proteins of parasitic helminth organisms infecting humans with no homologue in the host, human
and homologous to known drug targets in DrugBank.
No.
Cluster ID
Description from NR
database
Interpro
hits
C. elegans gene
ontology
Interaction partner
DrugBank targets
hits
(sequence
length)
Small drug molecules
Verified
with
known ES
protein
Trematodes
1
Fgigantica_U
N1535
malate
dehydrogenase
[Schistosoma
mansoni] (Evalue:1e49, identity:70.08)
IPR003767
Molecular
Function:
oxidoreductase
activity
(GO:0016491)
Hypothetical_protein
_CBG12370_[Caenor
habditis_briggsae] {
Evalue:2e-32,
identity:53.78}
Dehydrogenase
Nicotinamide-AdenineDinucleotide
yes
copper_type_II,_asco
rbatedependent_monooxy
genase,_putative_[Ix
Dopamine betahydroxylase
Vitamin C; Disulfiram;
Dopamine (approved)
No
Biological Process:
oxidation-reduction
process
(GO:0055114)
2
Fgigantica_U
N2703
dopamine-betamonooxygenase
[Schistosoma
mansoni] (Evalue:5e-
IPR000945
IPR008977
Molecular
Function:
dopamine betamonooxygenase
09, identity:52.83)
activity
(GO:0004500)
odes_scapularis] {
Evalue:3e-07,
identity:34.38}
Biological Process:
oxidation-reduction
process
(GO:0055114)
3
Ofelineus_U
N080
IPR007856
No annotation
IPR008139
(Hypothetical
protein)
4
Oviverrini_U
N2048,
UN0180,
UN0195,
UN0201,
UN0213,
UN0464,
UN0465,
UN2007,
UN2071,
UN2086
IPR011001
beta-galactosidase apeptide [Cloning
vector pTriplEx2]
IPR000683
IPR001155
IPR012615
IPR008979
Biological Process:
lipid metabolic
process
(GO:0006629)
No interacting
partner
Proactivator
polypeptide
Di-Stearoyl-3-SnPhosphatidylethanolamine
No
betagalactosidase_alpha_
polypeptide_[Cloning
_vector_pTriplEx]
Beta-galactosidase
Dimethyl sulfoxide
(approved)
No
1-(Isopropylthio)-BetaGalactopyranside
D-Galctopyranosyl-1-On
1-O-[O-Nitrophenyl]-BetaD-Galactopyranose
2-Fluoro-2-Deoxy-Beta-DGalactopyranose
(5r,6s,7s,8s)-5Hydroxymethyl-6,7,8Trihydroxy-Tetrazolo[1,5-
a]Piperidine
1-O-[P-Nitrophenyl]-BetaD-Galactopyranose
Allolactose
2-Deoxy-Beta-D-Galactose
S,S-(2Hydroxyethyl)Thiocysteine
Cestodes
5
Egranulosus_
UN0139,
UN0390,
UN1219,
Emultilocaris
_UN0174,
Tsolium_UN
5206
Hypothetical protein
[Taenia solium]
IPR001602
6
Serinaceieuro
paei_UN138
8
SJCHGC02198
protein [Schistosoma
japonicum]
IPR001584
IPR012337
Molecular
Function: DNA
binding
(GO:0003677),
Biological Process:
DNA integration
CG31688,_isoform_
C_[Drosophila_mela
nogaster]
BH3498 protein
Acetic acid (approved)
No
PREDICTED:_simila
r_to_polyprotein_[Da
nio_rerio]
Pol polyprotein
N-(4{[amino(imino)methyl]ami
no}butyl)-2,4'-bi-1,3thiazole-4-carboxamide
No
N-1H-imidazol-2-yl-N'-[4(1H-imidazol-2-
(GO:0015074)
7
8
Serinaceieuro
paei_UN182
8
Tsolium_UN
5517
procollagen-lysine,
2-oxoglutarate 5dioxygenase 3
[Schistosoma
japonicum]
ylamino)phenyl]benzene1,4-diamine
PREDICTED:_simila
r_to_lysyl_hydroxyla
se,_partial_[Ornithor
hynchus_anatinus]
Procollagenlysine,2oxoglutarate 5dioxygenase
Vitamin C
No
Succinic acid
(both approved)
phosphate
acetyl/butaryl
transferase
[Escherichia coli
M863]
IPR002505
Biological Process:
metabolic process
(GO:0008152),
Molecular
Function:
acyltransferase
activity
(GO:0008415)
predicted_phosphotra Glucose-1nsacetylase_subunit_[ phosphatase
Escherichia_coli_str.
_K12_substr._MG1655]
Alpha-D-Glucose-1Phosphate
No
putative Lipid
Binding Protein
[Angiostrongylus
cantonensis]
IPR000463
Molecular
Function:
transporter activity
(GO:0005215),
Biological Process:
transport
(GO:0006810),
Molecular
Lipid_Binding_Protei
n_family_member
mber_(lbp1)_[Caenorhabditis_e
legans]
S- Hydroxycysteine
yes
Nematodes
9
Aceylanicum
_UN0876
IPR011038
Myelin P2 protein
Palmitic Acid
Lauryl Dimethylamine-NOxide
Oleic Acid
Function: lipid
binding
(GO:0008289)
10
11
Aceylanicum
_UN1029
Aceylanicum
_UN3131
Hypothetical protein
CBG23341
[Caenorhabditis
briggsae]
IPR002172
CBR-GEI-7 protein
[Caenorhabditis
briggsae AF16]
IPR000918
IPR001465
IPR011076
IPR01581
12
Bmalayi_UN
01195
predicted pyruvate
formate lyase
[Escherichia coli str.
K-12 substr.
MG1655]
IPR004184
Molecular
Function: protein
binding
(GO:0005515)
Hypothetical_protein
_CBG23341_[Caenor
habditis_briggsae]
Low-density
lipoprotein receptor
Porfimer (approved)
yes
Molecular
Function: malate
synthase activity
(GO:0004474),
Biological Process:
glyoxylate cycle
(GO:0006097)
GEX_Interacting_pro
tein_family_member
_(gei7)_[Caenorhabditis_e
legans]
Isocitrate lyase
Glyoxalate, Glyoxylate
No
Cellular
Component:
cytoplasm
(GO:0005737),
Biological Process:
glucose metabolic
process
(GO:0006006),
Molecular
Function: formate
C-acetyltransferase
activity
Predicted_pyruvate_f
ormate_lyase_[Esche
richia_coli_str._K12_substr._MG1655]
Glycerol
dehydratase
1,2-Propanediol
No
Alpha-D-Mannose
(GO:0008861)
13
14
Bmalayi_UN
04283
Bmalayi_UN
09455
Sensor histidine
kinase DpiB
[Escherichia albertii
TW07627]
cyclophilin-type
peptidyl-prolyl cistrans isomerase-13,
Bmcyp-13 [Brugia
malayi]
IPR015891
sensory_histidine_kin
ase_in_twocomponent_regulator
y_system_with_citB_
[Escherichia_coli_str.
_K12_substr._MG1655]
Sensor kinase citA
C._briggsae_CBRCYN13_protein_[Caenorh
abditis_briggsae]
Peptidyl-prolyl cistrans isomerase,
mitochondrial
Heptamolybdate
No
Mo(Vi)(=O)(Oh)2
L-Proline (approved)
Yes
Dimethyl sulfoxide
(approved)
Methoxy-2-[2-(2-MethoxyEthoxy]-Ethane
7-AMINO-4-METHYLCHROMEN-2-ONE
15
Lloa_UN078
0
trypsin 5G1 [Culex
quinquefasciatus]
IPR001254
IPR01811
IPR009003
Molecular
Function: serinetype endopeptidase
activity
(GO:0004252),
Biological Process:
proteolysis
(GO:0006508)
CG14642,_isoform_
B_[Drosophila_mela
nogaster]
Myeloblastin
Fucose
No
16
Namericanus
_UN0697
UbiquinolCytochrome c
oxidoReductase
complex family
member (ucr-2.2)
[Caenorhabditis
elegans]
IPR007863
IPR011249
IPR001134
IPR00182
IPR00899
Molecular
Function:
metalloendopeptida
se activity
(GO:0004222),
Biological Process:
proteolysis
(GO:0006508),
Molecular
Function: zinc ion
binding
(GO:0008270)
Cytochrome b-c1
complex subunit 2,
mitochondrial
2-Hexyloxy-6HydroxymethylTetrahydro-Pyran-3,4,5Triol
No
5-n-undecyl-6-hydroxy-4,7dioxobenzothiazole
METHYL (2Z)-2-(2-{[6(2CYANOPHENOXY)PYRI
MIDIN-4YL]OXY}PHENYL)-3METHOXYACRYLATE
(5S)-3-ANILINO-5-(2,4DIFLUOROPHENYL)-5METHYL-1,3OXAZOLIDINE-2,4DIONE
FAMOXADONE
METHYL (2Z)-3METHOXY-2-{2-[(E)-2PHENYLVINYL]PHENY
L}ACRYLATE
17
Namericanus
Abnormal cell
migration protein 6,
IPR002223
Molecular
Function: serine-
Amyloid beta A4
Methionine Sulfoxide
Yes
18
_UN1021
isoform b, partially
confirmed
by transcript
evidence
[Caenorhabditis
elegans]
IPR02090
type endopeptidase
inhibitor activity
(GO:0004867)
Ovolvulus_U
N0760
hypothetical protein
LOAG_04392 [Loa
loa]
IPR008027
Cellular
Component:
mitochondrial
envelope
(GO:0005740),
Biological Process:
mitochondrial
electron transport,
ubiquinol to
cytochrome c
(GO:0006122),
Molecular
Function:
ubiquinolcytochrome-c
reductase activity
(GO:0008121)
protein
Cytochrome b-c1
complex subunit 9
2-Hexyloxy-6HydroxymethylTetrahydro-Pyran-3,4,5Triol
5-n-undecyl-6-hydroxy-4,7dioxobenzothiazole
METHYL (2Z)-2-(2-{[6(2CYANOPHENOXY)PYRI
MIDIN-4YL]OXY}PHENYL)-3METHOXYACRYLATE
5-HEPTYL-6-HYDROXY1,3-BENZOTHIAZOLE4,7-DIONE
ANILINO-5-(2,4DIFLUOROPHENYL)-5METHYL-1,3-
No
OXAZOLIDINE-2,4DIONE
(5S)-3-ANILINO-5-(2,4DIFLUOROPHENYL)-5METHYL-1,3OXAZOLIDINE-2,4DIONE
FAMOXADONE
METHYL (2Z)-3METHOXY-2-{2-[(E)-2PHENYLVINYL]PHENY
L}ACRYLATE
2-NONYL-4HYDROXYQUINOLINE
N-OXIDE
UBIQUINONE-2
19
Ovolvulus_U
N2296
Orn/Lys/Arg
decarboxylase, major
domain protein
[Escherichia coli MS
187-1]
IPR000310
IPR008286
IPR015424
Molecular
Function: catalytic
activity
(GO:0003824)
Biodegradative_argin
ine_decarboxylase_[
Escherichia_coli_str.
_K12_substr._MG1655]
Ornithine
decarboxylase,
inducible
Guanosine-5'-Triphosphate
No
20
Ovolvulus_U
N3521
adenosylmethionine8-amino-7oxononanoate
transaminase BioA
[Escherichia coli
UMNK88]
IPR005814
IPR005815
IPR015424
Molecular
Function:
adenosylmethionin
e-8-amino-7oxononanoate
transaminase
activity
(GO:0004015),
Biological Process:
biotin biosynthetic
process
(GO:0009102)
7,8diaminopelargonic_a
cid_synthase,_PLPdependent_[Escheric
hia_coli_str._K12_substr._MG1655]
Adenosylmethionin
e-8-amino-7oxononanoate
aminotransferase
7-Keto-8-Aminopelargonic
Acid
No
Amino-4-(4-AminoCyclohexa-2,5-Dienyl)Butyric Acid
N'-Pyridoxyl-Lysine-5'Monophosphate
21
Ovolvulus_U
N3760
predicted DNAbinding
transcriptional
regulator
[Escherichia coli str.
K-12 substr.
MG1655]
IPR000847
Molecular
Function:
sequence-specific
DNA binding
transcription factor
activity
(GO:0003700),
Biological Process:
regulation of
transcription,
DNA-dependent
(GO:0006355)
Predicted_DNAbinding_transcription
al_regulator_[Escheri
chia_coli_str._K12_substr._MG1655]
Hydrogen
peroxide-inducible
genes activator
Benzoic Acid
No
22
Sstercoralis_
UN0659
hypothetical protein
F58H1.7
[Caenorhabditis
IPR002172
Molecular
Function: protein
binding
hypothetical_protein_
F58H1.7_[Caenorhab
Low-density
lipoprotein
receptor-related
Antihemophilic Factor
Tenecteplase Coagulation
Yes
elegans]
(GO:0005515)
ditis_elegans]
protein 1
Factor IX
All biotech approved drugs
23
Sstercoralis_
UN2092
CRE-TAG-196
protein
[Caenorhabditis
remanei]
IPR013128
IPR01320
Molecular
Function: cysteinetype peptidase
activity
(GO:0008234)
Temporarily_Assigne
d_Gene_name_famil
y_member_(tag196)_[Caenorhabditis
_elegans]
Cathepsin F
[1-(1-Methyl-4,5-DioxoPent-2-Enylcarbamoyl)-2Phenyl-Ethyl]-Carbamic
Acid Benzyl Ester
[1-(1-Benzyl-3-Hydroxy-2Oxo-Propylcarbamoyl)-2Phenyl-Ethyl]-Carbamic
Acid Benzyl Ester
4-Morpholin-4-YlPiperidine-1-Carboxylic
Acid [1-(3Benzenesulfonyl-1-PropylAllylcarbamoyl)-2Phenylethyl]-Amide
Benzoyl-Arginine-AlanineMethyl Ketone
WRR-99
WRR-112
HOMOPHENYLALANIN
YLMETHANE
Yes
BENZOYL-TYROSINEALANINE-METHYL
KETONE
24
25
26
Sstercoralis_
UN2761
Tspiralis_UN
1020
Tspiralis_UN
4092
Serine/threonineprotein kinase H1
[Ascaris suum]
IPR011009
cleavage and
polyadenylation
specificity factor
subunit 2 [Trichinella
spiralis]
IPR003953
ribonucleotide
reductase R2 subunit
[Trichinella spiralis]
IPR020636
IPR000358
Molecular
Function:
transferase activity,
transferring
phosphoruscontaining groups
(GO:0016772)
Hypothetical_protein
_CBG22088_[Caenor
habditis_briggsae]
Calcium/calmoduli
n-dependent
protein kinase type
1D
N-(5-METHYL-1HPYRAZOL-3-YL)-2PHENYLQUINAZOLIN4-AMINE
No
Molecular
Function: electron
carrier activity
(GO:0009055),
Molecular
Function:
oxidoreductase
activity
(GO:0016491)
Hypothetical_protein
_CBG05192_[Caenor
habditis_briggsae]
Fumarate reductase
flavoprotein
subunit
Fumarate
Yes
Molecular
Function:
ribonucleosidediphosphate
reductase activity
(GO:0004748),
Biological Process:
Heme
Flavin-Adenine
Dinucleotide
Malate Like Intermediate
Citraconic acid
Ribonucleosidediphosphate
reductase M2
subunit
Cladribine
Gallium nitrate
(both approved)
No
deoxyribonucleosid
e diphosphate
metabolic process
(GO:0009186),
Biological Process:
oxidation-reduction
process
(GO:0055114)