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Table S2. Taxa, phylum or class, protein, and accession number for sequences from GenBank used in phylogenetic analyses of NRPS A domain. a. Bacteria Phylum Protein (module) Accession # Frankia sp. Actinobacteria AA adenylation YP_481079 Mycobacterium tuberculosis Actinobacteria peptide synthetase ZP_03425674 Streptomyces albus Actinobacteria ozmO ABS90476 Streptomyces clavuligerus Actinobacteria ACVS ZP_05002819 Bacillus amyloliquefaciens Firmicutes BaeJ YP_001421292 Bacillus cereus Firmicutes glycine-AMP ligase BC2306 Clostridium cellulolyticum Firmicutes AA adenylation YP_002506647 Achromobacter xylosoxidans Proteobacteria Pks12 EGP48546 Burkholderia cenocepacia Proteobacteria LCFAL YP_001763426 Burkholderia pseudomallei Proteobacteria NRPS ZP_03795572 Chondromyces crocatus Proteobacteria PKS/NRPS CAQ18839 marine gamma proteobacterium Proteobacteria peptide synthetase ZP_01618156 Marinobacter algicola Proteobacteria peptide synthetase ZP_01892961 Myxococcus xanthus Proteobacteria Ta1 CAB38084 Pseudomonas putida Proteobacteria non-ribosomal siderophore NP_746336 peptide synthetase b. Fungi Alternaria alternata Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Cochliobolus heterostrophus Arthroderma benhamiae Arthroderma gypseum Class Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Dothideomycetes Eurotiomycetes Eurotiomycetes Protein (module) AM-toxin NRPS1 NRPS2 NRPS3 NRPS4 NRPS5 NRPS6 NRPS7/PKS24 NRPS8 NRPS9 NRPS10 NPRS13 hypothetical protein L-aminoadipate-semialdehyde dehydrogenase Accession # AAF01762 AAX09983 AAX09984 AAX09985 AAX09986 AAX09987 AAX09988 AAR90278 AAX09990 AAX09991 AAX09992 AY884198 XP_003014124 XP_003176907 Arthroderma otae Aspergillus fumigatus Aspergillus fumigatus Aspergillus nidulans Aspergillus nidulans Aspergillus nidulans Aspergillus nidulans Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes NRPS NRPS6 SidE ACVS ACVS ACVS SidC XP_002850891 AAX11421 XP_748654 AN2621.4 AN2621.4 AN2621.4 AAP56239 Aspergillus niger Microsporum canis Penicillium chrysogenum Penicillium chrysogenum Penicillium chrysogenum Trichophyton equinum Trichophyton rubrum Trichophyton tosurans Trichophyton verrucosum Botrytis cinera Cordyceps bassiana Fusarium graminearum Chaetomium globosum Gibberella fujikuroi Gibberella zeae Magnaporthe grisea Metarhizium acridum Metarhizium anisopliae Neurospora crassa Trichoderma reesei Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Eurotiomycetes Leotiomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes Sordariomycetes hypothetical protein NRPS ACVS1 ACVS11 ACVS12 NRPS NRPS NRPS hypothetical protein hypothetical protein NRPS; tenellin PKS NRPS hypothetical protein PKS acyl CoA ligase-like protein Ace1 NRPS NRPS hypothetical protein PKS/NRPS CAK42046 EEQ28107 ABR12615 ABA70582 ABR12615 EGE01982 XP_003238870 EGD97139 XP_003020763 XP_001556764 CAL69597 XP_391202 XP_001224327 AAT28740 AAP12366 CAG28798 EFY84397 EFY95969 XP_963411 Trire2_58285
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