Download Table 2 - Genes down-regulated during the

Table 2 - Genes down-regulated during the secretory phase
ACCN.
FOLDGENE
DOWN
M77349
J02611
X57766
X15998
X52022
AJ000342
AL050214
D21255
M69148
J00123
-24.4
-18.7
TGFBI -transforming
growth factor, betainduced, 68kDa
APOD apolipoprotein D
-11.9
MMP11-matrix
metalloproteinase 11
(stromelysin 3)
-10.8
CSPG2-chondroitin
sulfate proteoglycan
2 (versican)
-8.0
-8.0
-7.9
-7.6
-6.4
-6.4
COL6A3-collagen,
type VI, alpha 3
DMBT1-deleted in
malignant brain
tumors 1
DKFZP586H2123
protein
CDH11-cadherin 11,
type 2, OB-cadherin
(osteoblast)
MDK -midkine
(neurite growthpromoting factor 2)
PENK -proenkephalin
U57646
-6.4
CSRP2-cysteine and
glycine-rich protein 2
AI362017
AF004430
-5.6
-5.3
CST3-cystatin C
TPD52L2-tumor
BIOLOGICAL
FUNCTION/
PATHWAY
(NETAFFX)
REGULATION BY
P. IN
ENDOMETRIUM
(LITERATURE)
Negative regulation
of cell adhesion.
Cell proliferation.
Integrin binding.
Decreased >80%
during the early to midluteal transition
Lipid metabolism.
Transport.
Development.
Embryogenesis and
morphogenesis.
Collagen
catabolism.
Heterophilic cell
adhesion.
Development. Cell
recognition.
Cell adhesion.
Muscle
development.
[18,20]
Up-regulated during
window of implantation
[11]
Suppressed by P in
secretory phase
[18,20] [46,47]
Down-regulated by P in
Ishikawa cells
[56]
Down-regulated during
decidualization in rat
[57]
Up-regulated in
secretory phase
[58]
Proteolysis and
peptidolysis.
Up-regulated by P in
cultured stroma
Cell adhesion.
Regulation of cell
cycle. Signal
transduction. Cellcell signalling.
Neurogenesis. Cell
proliferation. Cell
differentiation.
Signal transduction.
Neuropeptide
signalling pathway.
Cell-cell signalling.
Muscle
development. Cell
proliferation. Cell
growth. Cell
differentiation.
Extracellular matrix
remodelling.
Cell proliferation
[59]
Decreased in secretory
phase [20]
Restricted to
proliferative phase [48]
[18,20]
Down-regulated in
window of implantation
[11,19]
Suppressed by
progesterone [60]
protein D52-like 2
AF027208
-5.3
X16155
-5.0
PROM1-prominin 1
NR2F1 (COUP-TF)nuclear receptor
subfamily 2, group F,
member 1
X63556
-4.7
FBN1-fibrillin 1
(Marfan syndrome)
-4.4
ALDH1A1-aldehyde
dehydrogenase 1
family, member A1
-4.3
KPNA2-karyopherin
alpha 2 (RAG cohort
1, importin alpha 1)
-4.1
WNT5A -winglesstype MMTV
integration site
family, member 5A
L02870
-4.0
COL7A1-collagen,
type VII, alpha 1
AF041243
-3.7
X70683
-3.7
M20777
-3.6
HCRTR1-hypocretin
(orexin) receptor 1
SOX4-SRY (sex
determining region
Y)-box 4
COL6A2-collagen,
type VI, alpha 2
L04658
-3.6
CDK5-cyclindependent kinase 5
AB002134
-3.5
AJ005670
-3.4
D87119
-3.3
K03000
U28386
L20861
HAT -airway trypsinlike protease
DACH -Dachshund
homolog (Drosophila)
TRB2-tribbles
homolog 2
Integral to plasma
membrane.
Regulation of
transcription, DNAdependent. Signal
transduction
Skeletal
development.
Development.
Vision.
Aldehyde
metabolism.
Glycolysis /
Gluconeogenesis.
Regulation of DNA
recombination. G2
phase of mitotic cell
cycle. DNA
metabolism.
Intracellular protein
transport. Spindle
pole body and
microtubule cycle.
Frizzled-2 signalling
pathway. Cell-cell
signalling.
Development.
Embryogenesis and
morphogenesis.
Wnt Signalling
Cell adhesion.
Epidermal
differentiation.
Neuropeptide
signalling pathway.
Synaptic
transmission.
Regulation of
transcription, DNAdependent.
Muscle
development.
Cytokinesis. Protein
amino acid
phosphorylation.
Cell cycle.
Proteolysis and
peptidolysis.
Respiratory
gaseous exchange.
Cell growth and/or
maintenance.
Protein amino acid
phosphorylation.
Decreased in luteal
phase [18]
AL049998
-3.2
J03040
-3.2
PIK3C2A phosphoinositide-3kinase, class 2, alpha
polypeptide
SPARC -secreted
protein, acidic, richrich (osteonectin)
X06700
-3.1
COL3A1-collagen,
type III, alpha 1
Y12505
-3.1
HTR4-5hydroxytryptamine
(serotonin) receptor 4
AB023149
-3.1
U30521
-3.1
Y12711
-3.0
AA704137
-3.0
D10522
-2.9
L36033
-2.9
Y11999
-2.9
X05610
-2.9
Z24727
-2.9
AB017563
-2.8
TLL2-tolloid-like 2
C5orf13chromosome 5 open
reading frame 13
PGRMC1progesterone
receptor membrane
component 1
THY1-Thy-1 cell
surface antigen
MARCKS myristoylated
alanine-rich protein
kinase C substrate
CXCL12-chemokine
(C-X-C motif) ligand
12 (stromal cellderived factor 1)
ITPKC -inositol 1,4,5trisphosphate 3kinase C
COL4A2-collagen,
type IV, alpha 2
TPM1-tropomyosin 1
(alpha)
IGSF4immunoglobulin
phosphatidylinositol
biosynthesis.
Intracellular
signalling cascade.
Ossification.
Histogenesis and
organogenesis.
Circulation.
Inflammatory
response pathway
GPCRs Class A
Rhodopsin-like.
Monoamine
GPCRs.
Proteolysis and
peptidolysis.
Repressed by P. in rat
[11,53]
Cell motility.
Calcium ion
homeostasis.
Chemotaxis.
inflammatory
response. Immune
response. Cell
adhesion. G-protein
coupled receptor
protein signalling
pathway. Cell-cell
signalling.
Circulation.
Regulation of actin
polymerization.
Extracellular matrix
organization and
biogenesis.
Regulation of
muscle contraction.
Decreased in luteal
phase [18]
Z83844
D78014
-2.6
superfamily, member
4
LGALS1-lectin,
galactoside-binding,
soluble, 1 (galectin 1)
-2.6
DPYSL3dihydropyrimidinaselike 3
X87838
-2.6
X60435
-2.5
M25915
-2.5
CTNNB1-catenin
(cadherin-associated
protein), beta 1,
88kDa
ADCYAP1-adenylate
cyclase activating
polypeptide 1
(pituitary)
CLU -clusterin
(complement lysis
inhibitor, SP-40,40,
sulfated glycoprotein
2, testosteronerepressed prostate
message 2,
apolipoprotein J)
IGFBP4-insulin-like
growth factor binding
protein 4
NCOR2-nuclear
receptor co-repressor
2
PKP3-plakophilin 3
U20982
-2.5
U37146
Z98265
-2.4
-2.4
K02581
-2.4
AF016507
-2.4
TK1-thymidine kinase
1, soluble
CTBP2-C-terminal
binding protein 2
S79639
-2.3
EXT1-exostoses
(multiple) 1
Apoptosis.
Heterophilic cell
adhesion.
Nucleobase,
nucleoside,
nucleotide and
nucleic acid
metabolism. Signal
transduction.
Neurogenesis.
Regulation of
transcription from
Pol II promoter. Cell
adhesion. TGF Beta
signalling pathway.
Wnt Signalling.
Lipid metabolism.
Apoptosis.
Complement
activation, classical
pathway.
Fertilization. Cell
death.
Skeletal
development.
Regulation of cell
growth. DNA
metabolism. Signal
transduction. Cell
proliferation.
Cell adhesion.
DNA metabolism.
Pyrimidine
metabolism
Negative regulation
of cell proliferation.
Skeletal
development.
Glycosaminoglycan
biosynthesis. Signal
transduction. Cell
growth and/or
maintenance.
Negative regulation
of cell cycle.
AL120815
-2.3
D44466
-2.2
U10688
-2.2
AF053944
AF026692
-2.2
-2.2
U73824
-2.2
M76125
-2.2
X59543
-2.1
U18244
-2.1
U68186
-2.1
D87969
-2.1
J04599
X51688
-2.1
-2.1
LITAF lipopolysaccharideinduced TNF factor
PSMD1-proteasome
(prosome,
macropain) 26S
subunit, non-ATPase,
1
MAGEA4-melanoma
antigen, family A, 4
AEBP1-AE binding
protein 1
SFRP4-secreted
frizzled-related
protein 4
EIF4G2-eukaryotic
translation initiation
factor 4 gamma, 2
AXL -AXL receptor
tyrosine kinase
RRM1-ribonucleotide
reductase M1
polypeptide
SLC1A6-solute
carrier family 1 (high
affinity
aspartate/glutamate
transporter), member
6
ECM1-extracellular
matrix protein 1
C6orf165chromosome 6 open
reading frame 165
Regulation of
transcription from
Pol II promoter.
Proteasome
degradation.
Skeletal
development.
Proteolysis and
peptidolysis. Cell
adhesion. Muscle
development.
Signal transduction.
Development.
Embryo
implantation. Wnt
signalling.
Regulation of
protein
biosynthesis.
Regulation of
translational
initiation. Cell cycle
arrest. Cell death.
[51,52] [11,18,20]
DNA replication.
Purine metabolism.
Pyrimidine
metabolism.
Nucleotide
metabolism.
Dicarboxylic acid
transport. Synaptic
transmission. Laspartate transport.
L-glutamate
transport.
Down-regulated
during window of
implantation [11]
BGN -biglycan
CCNA2-cyclin A2
Down-regulated in
secretory phase
Regulation of CDK
activity. Cytokinesis.
Mitosis. Mitotic G2
checkpoint. Cell
cycle
AB005043
-2.1
SOCS1-suppressor
of cytokine signalling
1
M77698
-2.1
YY1-YY1
transcription factor
M36341
-2.0
Y14690
-2.0
ARF4-ADPribosylation factor 4
COL5A2-collagen,
type V, alpha 2
Regulation of cell
growth. Intracellular
signalling cascade.
JAK-STAT cascade.
Regulation of
transcription from
Pol II promoter.
Antimicrobial
humoral response.
Intracellular protein
transport. Small
GTPase mediated
signal transduction.
Cell growth and/or
maintenance.
ACCN. : GenBank accession number
Additional reference list:
56.
EE Hanekamp, SC Gielen, E Smid-Koopman, LC Kuhne, PE de Ruiter, S
Chadha-Ajwani, AO Brinkmann, JA Grootegoed, CW Burger, FJ Huikeshoven,
LJ Blok: Consequences of loss of progesterone receptor expression in
development of invasive endometrial cancer. Clin Cancer Res 2003, 9: 41904199.
57.
J Mulholland, JD Aplin, S Ayad, L Hong, SR Glasser: Loss of collagen type VI
from rat endometrial stroma during decidualization. Biol Reprod 1992, 46:
1136-1143.
58.
CI Ace, WC Okulicz: A progesterone-induced endometrial homolog of a new
candidate tumor-suppressor, DMBT1. J Clin Endocrin Metab 1998, 83: 35693573.
59.
GT Chen, S Getsios, CD MacCalman: Cadherin-11 is a hormonally regulated
cellular marker of decidualization in human endometrial stromal cells. Mol
Reprod Dev 1999, 52: 158-165.
60.
OD Slayden, K Hettrich, RS Carroll, LN Otto, AL Clark, RM Brenner: Estrogen
enhances cystatin C expression in the macaque vagina. J Clin Endocrinol
Metab 2004, 89: 883-891.