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Supplemental Table 1. Differentially expressed genes following diactamnine exposure Systematic Name a Standard Gene mame YLL055W YBL005W PDR3 YOL151W GRE2 YHR140W YKL071W YGR281W YOR1 YLR346C YNL160W YGP1 YLL056C YOR049C YOL150C YFR030W YDR011W YPL261C YAL061W YPL136W YNL202W YKL001C RSB1 MET10 SNQ2 SPS19 MET14 YCR061W YLR303W YOR153W YBL065W MET17 PDR5 Fold Changeb product 34.0180 Hypothetical ORF Zinc-finger transcription factor related to 24.4367 Pdr1p NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress 24.3935 induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway 24.2269 Hypothetical ORF 23.7927 Hypothetical ORF 22.0427 ABC transporter Protein of unknown function; expression 21.1357 regulated by PDR1 gp37, a glycoprotein synthesized in response 18.4927 to nutrient limitation which is homologous to the sporulation-specific SPS100 gene 17.0376 Hypothetical ORF Resistance to Sphingoid long-chain Base. Putative transporter or flippase that 15.7267 translocates LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane. 14.8097 Hypothetical ORF 14.0085 Sulfite reductase alpha subunit 13.3661 ABC transporter 13.0429 Hypothetical ORF 13.0367 Putative polyol dehydrogenase 12.7651 Hypothetical ORF 12.5606 2,4-dienoyl-CoA reductase 11.9437 Adenylylsulfate kinase Protein of unknown function; green fluorescent protein (GFP)-fusion protein 11.5215 localizes to the cytoplasm in a punctate pattern 11.3605 O-acetylhomoserine (thiol)-lyase 11.1768 Multidrug resistance transporter 10.6658 Hypothetical ORF YER185W YIR017C MET28 YJR010W YLL060C YPR167C MET3 GTT2 MET16 YOR328W PDR10 YGL157W YKL162C-A YLR070C YDR406W XYL2 PDR15 YLR099C ICT1 YFL032W YML007C-A YOL085C YHR029C YNL203C YBR180W DTR1 YMR107W YMR102C YCR010C YNL134C YJL028W YAL042C-A ADY2 YGR035C YBR296C PHO89 YBR294W SUL1 YJR137C ECM17 10.5751 Hypothetical ORF Transcriptional activator in the 10.5446 Cbf1p-Met4p-Met28p complex 10.2359 ATP sulfurylase 10.1722 Glutathione transferase 9.9444 3phosphoadenylylsulfate reductase ABC transporter (putative)|highly similar to 9.9413 Pdr5p Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione 9.4784 (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2one (BCO2one6ol) 9.2599 Similar to PIR1, PIR2 and PIR3 proteins 8.8878 Xylitol Dehydrogenase 8.4551 Multidrug resistance transporter (putative) Protein of unknown function, null mutation leads to an increase in sensitivity to 8.3049 Calcofluor white; expression of the gene is induced in the presence of isooctane 8.2331 Hypothetical ORF Hypothetical ORF identified by homology. 8.2168 See FEBS Letters [2000] 487:31-36. 7.9293 Hypothetical ORF 7.8171 Hypothetical ORF 7.7313 Hypothetical ORF 7.7091 Dityrosine transporter MFS-MDR Protein required for survival at high 7.3442 temperature during stationary phase 7.2936 Hypothetical ORF 7.2769 Transmembrane protein 7.2467 7.0916 Hypothetical ORF 7.0871 Hypothetical ORF Protein of unknown function, potential 7.0658 Cdc28p substrate 6.1768 Na+/Pi symporter (putative) Sulfate uptake is mediated by specific sulfate transporters SUL1 and SUL2, which control 6.1742 the concentration of endogenous activated sulfate intermediates. 6.1227 Sulfite reductase beta subunit YHR139C SPS100 6.0301 YOR348C PUT4 5.6605 YML100W TSL1 5.6320 YLL057C 5.5611 YDR070C 5.5200 YLR152C YJL163C YLR338W 5.5049 5.5020 5.4195 YMR322C SNO4 5.3514 YDR374C 5.3125 YPL280W 5.1942 YOR391C YNL337W YGL156W YOR237W YOR152C YKR076W YBR067C YJR162C YOR214C YMR291W 5.1747 5.1728 5.0580 5.0323 5.0234 5.0120 5.0028 4.9422 4.9337 4.9178 AMS1 HES1 ECM4 TIP1 YPL250C YIL170W YNL276C YKL051W YJL219W YLR178C 4.8937 HXT12 SFK1 HXT9 TFS1 4.8896 4.8871 4.8543 4.8013 4.7760 Sporulation-specific cell wall maturation protein Proline specific permease Similar to TPS3 gene product/trehalose-6-phosphate synthase/phosphatase complex 123 kDa regulatory subunit Similar to Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; EC 1.14.11.17 The authentic, non-tagged protein was localized to the mitochondria Hypothetical ORF Hypothetical ORF Hypothetical ORF Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in pyridoxine metabolism Hypothetical ORF Probable heat-shock chaperone and possible cysteine protease; one of a mini-family of homologous genes in S. cerevisiae including YDR533C, YOR391C, and YMR322C Hypothetical ORF Alpha mannosidase Similar to human oxysterol binding protein Hypothetical ORF ExtraCellular Mutant Cell wall mannoprotein Hypothetical ORF Hypothetical ORF Hypothetical ORF Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport, interacts genetically with TCP1 and ICY1 Putative hexose permease Hypothetical ORF Suppressor of PI Four Kinase Hexose permease Lipid binding protein (putative)|supressor of a cdc25 mutation Hypothetical ORF NADP-linked glutamate dehydrogenase Hypothetical ORF The RAD59 gene product has homology to the Rad52 protein YPL062W YAL062W YAL018C GDH3 4.7348 4.7070 4.6713 YDL059C RAD59 4.6651 YDL085W YJL045W NDE2 4.6645 4.6495 Similar to SDH1 The authentic, non-tagged protein was 4.5649 localized to the mitochondria Involved in ubiquitin degradation pathway. 4.5090 May act as common transcription factor on proteasomal and proteasome-related genes. 4.4973 Hypothetical ORF Protein of unknown function; green 4.4926 fluorescent protein (GFP)-fusion protein localizes to the cell periphery 4.4820 Involved in nitrosoguanidine resistance Methylenetetrahydrofolate reductase (mthfr) 4.4697 (putative) 4.4563 Hypothetical ORF S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in sulfate 4.3906 assimilation, methionine metabolism, and siroheme biosynthesis 4.3691 Hypothetical ORF 4.3461 Gamma-glutamylcysteine synthetase 4.3411 Homoserine O-trans-acetylase 4.3222 Glucose permease Multistress response protein,Jexpression isJactivated byJa variety of xenobiotic agents 4.2886 and environmental or physiological stressesJJJ 4.2737 High affinity sulfate permease 4.2528 Inhibitor of proteinase Pep4p 1,3-beta-D-glucan synthase catalytic 4.1949 component 4.1943 Hypothetical ORF 4.1779 Arylformamidase The authentic, non-tagged protein was 4.1038 localized to the mitochondria 4.0893 Exo-1,3-beta-glucanase, sporulation-specific 4.0872 Hypothetical ORF YKR049C YDL020C RPN4 YGR201C YDR034WB YGR197C SNG1 YGL125W MET13 YGL007W YKR069W MET1 YLR050C YJL101C YNL277W YOL156W GSH1 MET2 HXT11 YOL052C-A DDR2 YLR092W YMR174C SUL2 PAI3 YGR032W GSC2 YAL069W YJL060W BNA3 YGR052W YOR190W YKR012C SPR1 YBL101C YPR151C YNL305C ECM21 YOL084W PHM7 YPL171C OYE3 YMR094W CTF13 YMR096W SNZ1 YPR150W YHR112C YGR059W SPR3 YBL075C YIL101C YFL056C YLR149C YHR139C-A YHR176W YKL221W SSA3 XBP1 AAD6 YHL024W RIM4 YBL078C ATG8 YGR044C RME1 FMO MCH2 YKL086W YNR019W ARE2 YLL016W YOL118C YOL064C SDC25 YOR173W DCS2 MET22 4.0135 ExtraCellular Mutant 3.9580 3.9504 Hypothetical ORF Protein of unknown function, expression is regulated by phosphate levels; green 3.9490 fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole 3.9375 NADPH dehydrogenase Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending 3.9372 the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis Highly conserved 35 kDa protein that shows 3.9318 increased expression after entry into stationary phase 3.8953 Hypothetical ORF 3.8816 Hypothetical ORF A sporulation-specific homologue of the 3.8594 yeast CDC3/10/11/12 family of bud neck microfilament genes; regulated by ABFI 3.8532 Heat shock protein of HSP70 family 3.8446 Transcriptional repressor 3.8424 Aryl-alcohol dehydrogenase (putative) 3.8214 Hypothetical ORF 3.8096 Hypothetical ORF 3.7783 Flavin-containing monooxygenase 3.7669 Monocarboxylate permease homologue RNA-binding protein of the RRM class 3.7590 (putative) Similar to LC3, a microtubule-associated 3.7426 protein from rat Zinc finger protein|negative regulator of 3.7293 meiosis; directly repressed by a1-alpha 2 regulator ATP-dependent cysteine sulfinic acid 3.7177 reductase Acyl-CoA cholesterol acyltransferase 3.6949 (sterol-ester synthetase) 3.6731 GDP/GTP exchange factor for Ras 3.6606 Hypothetical ORF 3.6581 3(2)5-bisphosphate nucleotidase Non-essential protein containing a HIT 3.6336 (histidine triad) motif; regulated by Msn2p, YJR078W YHR180W BNA2 3.6284 3.6239 YJL079C PRY1 3.6109 YKL225W YAR035W YFL014W YAT1 HSP12 3.5973 3.5967 3.5824 YKL201C MNN4 3.5712 YDR379C-A 3.5602 YDR010C YNL237W YHR138C YGR154C YKL178C STE3 3.5429 3.5425 3.5242 3.5186 3.5090 YJL082W IML2 3.4914 YGL205W YNR044W YKL008C YGL184C YLR307W POX1 AGA1 LAC1 STR3 CDA1 3.4867 3.4601 3.4555 3.4516 3.4350 YDR253C MET32 3.4321 YGL183C YMR272C YMR090W YML089C MND1 SCS7 3.4088 3.3623 3.3597 3.3593 YLL028W TPO1 3.3548 RTS3 VPS73 3.3234 3.3100 3.3068 YJR079W YGR161C YGL104C YTP1 Msn4p, and the Ras-cAMP-cAPK signalling pathway, transcript accumulates under glucose limitation, similar to Dcs1pJJJ Tryptophan 2,3-dioxygenase Hypothetical ORF Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein. Hypothetical ORF Carnitine acetyltransferase Heat shock protein 12 Required for the transfer of mannosylphosphate to cell wall mannans. Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. Hypothetical ORF Yeast putative Transmembrane Protein Homologous to PBI2 Hypothetical ORF A-factor receptor Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Fatty-acyl coenzyme A oxidase A-agglutinin anchorage subunit LAG1 longevity gene homolog Cystathionine beta-lyase Chitin deacetylase Highly homologous to Met31p|transcriptional regulator of sulfur amino acid metabolism|zinc finger protein Needed for Meiotic Nuclear Divisions Desaturase|hydroxylase Hypothetical ORF Hypothetical ORF Plasma membrane-bound exporter, involved in the detoxification of excess spermidine Hypothetical ORF Hypothetical ORF YHR217C YML083C YGR243W YER109C YBR072W FLO8 HSP26 YDR403W DIT1 YPL067C YML125C YMR323W YPL281C ERR2 YDR073W SNF11 YNL195C YIL074C YBL102W SER33 SFT2 YMR191W YLR364W YBR213W YLR327C YLR247C YJL172W YCL023C YGR087C YMR208W MET8 CPS1 PDC6 ERG12 YER091C MET6 YOR230W YMR017W YGR043C YOL119C YCL041C WTM1 SPO20 MCH4 3.3060 Hypothetical ORF 3.2971 Hypothetical ORF The authentic, non-tagged protein was 3.2876 localized to mitochondria 3.2763 Transcriptional activator of FLO1 (putative) 3.2685 Heat shock protein 26 First enzyme in dityrosine synthesis in the 3.2551 outer layer of the spore wall pathway, converting L-tyrosine to N-formyl-L-tyrosine 3.2419 Hypothetical ORF 3.2220 Protein required for cell viability 3.2217 Hypothetical ORF Protein of unknown function, has similarity 3.2112 to enolases SWI/SNF global transcription activator 3.2086 complex component 3.1867 Hypothetical ORF 3.1851 3-phosphoglycerate dehydrogenase 3.1816 Similar to mammalian syntaxin 5 Protein required for survival at high 3.1722 temperature during stationary phase 3.1672 Hypothetical ORF Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of 3.1579 siroheme; also involved in the expression of PAPS reductase and sulfite reductaseJJJ 3.1574 Hypothetical ORF 3.1571 Hypothetical ORF 3.1555 Carboxypeptidase yscS 3.1514 Hypothetical ORF 3.1508 Pyruvate decarboxylase isozyme 3.1412 Mevalonate kinase Vitamin B12-(cobalamin)-independent isozyme of methionine synthase (also called N5-methyltetrahydrofolate homocysteine 3.1327 methyltransferase or 5-methyltetrahydropteroyl triglutamate homocysteine methyltransferase) 3.1222 Transcriptional modulator 3.1191 SNAP 25 homolog 3.0844 Hypothetical ORF 3.0805 Monocarboxylate permease homologue 3.0751 Protein required for cell viability YAL066W YMR297W PRC1 YIR018W YAP5 YBR284W YLR112W YOR347C YNL331C PYK2 AAD14 YPR049C ATG11 YER142C YDR059C MAG1 UBC5 YGR019W UGA1 YBR117C TKL2 YIR019C MUC1 YCL040W YLR101C YOL048C YOL001W YPR127W YNR071C YGL012W YNL231C GLK1 YOR370C MRS6 YEL060C YKR033C YLR046C YLR100W YJL027C YMR304W YLR056W PRB1 YHR057C CPR2 YDL246C SOR2 PHO80 ERG4 PDR16 ERG27 UBP15 ERG3 3.0744 Hypothetical ORF 3.0693 Carboxypeptidase Y (proteinase C) bZIP (basic-leucine zipper) 3.0577 protein|transcription factor 3.0501 Hypothetical ORF 3.0487 Hypothetical ORF 3.0484 Pyruvate kinase, glucose-repressed isoform 3.0359 Aryl-alcohol dehydrogenase (putative) Oligomeric, coiled-coil, peripheral membrane 3.0195 protein required for stable binding of precursor API to its target membrane. 3.0121 3-methyladenine DNA glycosylase 3.0068 Ubiquitin-conjugating enzyme Gamma-aminobutyrate (GABA) 3.0004 transaminase (4-aminobutyrate aminotransferase) 2.9981 Transketolase, similar to TKL1 Cell surface flocculin with structure similar 2.9846 to serine/threonine-rich GPI-anchored cell wall proteins 2.9836 Glucokinase 2.9810 Protein required for cell viability 2.9784 Hypothetical ORF 2.9775 Pho80p cyclin 2.9704 Hypothetical ORF 2.9691 Hypothetical ORF 2.9627 Sterol C-24 reductase 2.9597 Pdr17p homolog|Sec14p homolog Rab geranylgeranyltransferase regulatory 2.9574 subunit 2.9466 Vacuolar protease B 2.9433 Hypothetical ORF 2.9386 Hypothetical ORF 2.9365 3-keto sterol reductase 2.9293 Hypothetical ORF 2.9276 Deubiquitinating enzyme (putative) 2.9274 C-5 sterol desaturase Cyclophilin|peptidyl-prolyl cis-trans 2.9195 isomerase (PPIase) Protein of unknown function, computational analysis of large-scale protein-protein 2.9092 interaction data suggests a possible role in fructose or mannose metabolism YPL054W YPL154C LEE1 PEP4 YDL024C DIA3 YML042W CAT2 YFL057C AAD16 YJL037W YER130C YIL117C PRM5 YAL067C YJL016W YBR139W SEO1 YMR095C SNO1 YPR006C YDR072C YMR306CA YMR262W YPL061W ICL2 IPT1 2.7859 Hypothetical ORF ALD6 YCR018C-A YDR436W PPZ2 YER004W YOR285W YBR212W YPL006W YLR217W NGR1 NCR1 YBL064C PRX1 YNL259C ATX1 YAL028W 2.8716 Product of gene unknown 2.8583 Vacuolar proteinase A Protein of unknown function, involved in 2.8444 invasive and pseudohyphal growth 2.8371 Carnitine O-acetyltransferase Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol 2.8347 dehydrogenase; mutational analysis has not yet revealed a physiological role 2.8343 Hypothetical ORF 2.8302 Hypothetical ORF Pheromone-regulated protein, predicted to 2.8228 have 1 transmembrane segment; induced during cell integrity signalling 2.8226 Permease (putative) 2.8206 Hypothetical ORF 2.8103 Hypothetical ORF Protein of unknown function, involved in pyridoxine metabolism; expression is induced 2.8061 during stationary phase; may be part of a complex that also contains Snz1p 2.8045 2-methylisocitrate lyase 2.7984 Inositolphosphotransferase 1 2.7816 Hypothetical ORF 2.7739 Aldehyde dehydrogenase Similar to probable membrane protein 2.7729 YLR334C and ORF YOL106W 2.7608 Serine-threonine phosphatase Z The authentic, non-tagged protein was 2.7514 localized to the mitochondria 2.7504 Hypothetical ORF 2.7470 Glucose-repressible RNA binding protein 2.7358 Transmembrane protein (putative) 2.7327 Hypothetical ORF Also called mTPx I, a mitochondrial isoform 2.7248 of thioredoxin peroxidase (EC 1.11.1.-) Copper binding homeostasis protein 2.7202 (putative) Exhibits physical and genetic interactions 2.6986 with FRT1 and genetic interactions with TCP1; contains a C-terminal transmembrane YPL185W YGR066C YKR102W YOL099C YJL038C YAR070C YGL180W YPL018W YML058WA YCR023C YLR054C YOR124C YMR315W YLL063C YDR256C YPL036W YDL130WA YKL202W YLR041W 2.6964 2.6954 FLO10 2.6924 ATG1 CTF19 2.6867 2.6805 2.6797 2.6773 2.6751 HUG1 2.6703 AYT1 CTA1 PMA2 2.6634 2.6568 2.6562 2.6547 2.6516 2.6495 2.6492 STF1 2.6444 ATPase stabilizing factor UBP2 YMR306W FKS3 YDR281C PHM6 YIR016W YBR241C YNL036W YPL272C YMR196W YIL056W YPL052W YBR124W YJR025C YMR097C YOL129W YOR393W domain and shows localization to the plasma membrane, the ER, and cytoplasmic vesicular or granule-like structures Hypothetical ORF Hypothetical ORF Protein with similarity to flocculation protein Flo1p Hypothetical ORF Hypothetical ORF Hypothetical ORF Protein kinase Kinetochore protein Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage Hypothetical ORF Outer Spore Wall Ubiquitin-specific protease Hypothetical ORF Transacetylase Catalase A Plasma membrane ATPase NCE103 BNA1 MTG1 VPS68 ERR1 2.6440 Hypothetical ORF 2.6327 Hypothetical ORF Protein with similarity to Gls1p and Gls2p 2.6261 (GB:Z49212) Protein of unknown function, expression is 2.6238 regulated by phosphate levels 2.6011 Hypothetical ORF 2.5888 Hypothetical ORF 2.5837 Carbonic anhydrase-like protein 2.5761 Hypothetical ORF 2.5730 Hypothetical ORF 2.5729 Hypothetical ORF 2.5614 Hypothetical ORF 2.5605 Hypothetical ORF 2.5533 3-hydroxyanthranilic acid dioxygenase 2.5518 GTPase 2.5485 2.5370 Enolase homolog YGR153W YBR280C YGL141W YFL063W HUL5 2.5362 2.5357 2.5299 2.5281 YOL047C 2.5280 YHL037C YHL042W YBR053C YBR105C YIL010W VID24 DOT5 2.5269 2.5192 2.5165 2.5112 2.5086 YML132W COS3 2.5084 YNR058W BIO3 2.5073 YFL062W COS4 2.5067 YLR099WA YER138WA YIR034C YIR028W LYS1 DAL4 YKR050W TRK2 YIL048W YIR027C NEO1 DAL1 YOR316C COT1 2.5057 Hypothetical ORF Hypothetical ORF Ubiquitin ligase (E3) Hypothetical ORF Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Hypothetical ORF Hypothetical ORF Hypothetical ORF Peripheral vesicle membrane protein EC 1.11.1.Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins 7,8-diamino-pelargonic acid aminotransferase (DAPA) aminotransferase Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. 2.5053 Similar to TyB and TyA YFR012W-A YBR151W APD1 YBR302C COS2 YBR062C YJR151C YNL156C DAN4 2.5045 Saccharopine dehydrogenase 2.5036 Allantoin permease Low affinity potassium transport|membrane 2.4989 protein 2.4983 P-type ATPase 2.4971 Allantoinase Vacuolar transporter that mediates zinc 2.4947 transport into the vacuole; overexpression confers resistance to cobalt and rhodium Hypothetical ORF identified by homology. 2.4939 See FEBS Letters [2000] 487:31-36. 2.4884 Actin patches distal Protein of unknown function, member of a 2.4872 family of conserved, often subtelomerically-encoded proteins 2.4808 Hypothetical ORF 2.4791 Cell wall mannoprotein 2.4696 Protein of unknown function, potential YFL015C YMR009W YPR198W 2.4620 2.4545 SGE1 YBR293W 2.4434 2.4426 YER069W ARG5,6 2.4400 YPL135W ISU1 2.4261 YPR184W GDB1 2.4248 YKL103C YKL053W YJL216C YIL153W YBR008C YLR267W YDR476C YNL338W YGR060W YDR259C YOR142WA YDL159WA YOR040W YML007W YDR095C YPL277C YPL113C LAP4 2.4176 2.4034 2.4018 2.4011 2.3968 2.3912 2.3848 2.3827 2.3799 2.3760 GLO4 YAP1 2.3615 2.3606 2.3581 2.3563 2.3536 YJL170C ASG7 2.3508 YOR374W YMR175W YNL274C ALD4 SIP18 2.3491 2.3465 2.3460 YML048W GSF2 2.3420 YIL046W MET30 2.3395 RRD1 FLR1 ERG25 YAP6 2.3759 2.3625 homolog of mammalian Insig 1 Hypothetical ORF Hypothetical ORF Multi-copy suppressor of gal11 null; member of drug-resistance protein family Hypothetical ORF N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase Iron-sulfur cluster nifU-like protein Glycogen debranching enzyme; the enzyme that debranches the glycogen having a glucanotranferase + 1-6amyloglucosidase activity Vacuolar aminopeptidase ysc1 Hypothetical ORF Hypothetical ORF Resistant to Rapamycin Deletion major facilitator transporter Bypass of PAM1 Hypothetical ORF Hypothetical ORF C-4 sterol methyl oxidase bZIP protein TyA Gag protein; the main structural constituent of virus-like particles (VLPs) Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. Glyoxylase-II jun-like transcription factor Hypothetical ORF Hypothetical ORF Putative dehydrogenase An a-specific gene that is induced to a higher expression level by alpha factor aldehyde dehydrogenase Salt-Induced Protein Putative hydroxyisocaproate dehydrogenase ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Contains five copies of WD40 motif and interacts with and regulates Met4p YDR055W PST1 2.3394 YKL210W YPL114W YOR134W YOR220W YJR020W UBA1 2.3354 2.3335 2.3323 2.3291 2.3286 BAG7 YDR533C YDL169C YJR159W 2.3261 UGX2 SOR1 2.3153 2.3149 YNL045W 2.3089 YDL086W YBL107WA YHR096C YIL012W YOL158C YAL051W YDR216W YFR012W YDL085C-A YLL061W YCR060W YLR281C YBL103C 2.3067 the gene product has been detected among the proteins secreted by regenerating protoplasts Ubiquitin activating enzyme e1 Hypothetical ORF GTPase activating protein (GAP) Hypothetical ORF Hypothetical ORF Protein crystal structure indicates structural and functional homology to E. coli Hsp31, a chaperone and putative cysteine protease; expression upregulated on heat-shock and oxidative stress; one four homologous genes in S. cerevisiae Product of gene unknown Sorbitol dehydrogenase, sorbitol-induced Similar to human LTA4 hydrolase but in vivo substrates not yet defined. Hypothetical ORF 2.3037 Similar to TyA and TyB proteins HXT5 ENB1 OAF1 ADR1 MMP1 RTG3 YDL123W SNA4 YGR260W TNA1 YPL150W YDR170WA YDL210W UGA4 YER044C ERG28 2.2998 2.2981 2.2929 2.2865 2.2836 2.2814 2.2802 2.2785 2.2756 2.2713 2.2670 hexose transporter Hypothetical ORF enterobactin transporter transcription factor positive transcriptional regulator Hypothetical ORF Hypothetical ORF High affinity S-methylmethionine permease Hypothetical ORF Hypothetical ORF Phosphoprotein Protein of unknown function, localized to the 2.2668 vacuolar outer membrane High affinity nicotinic acid plasma 2.2650 membrane permease 2.2646 Hypothetical ORF 2.2643 Ty ORF 2.2635 GABA-specific transport protein Endoplasmic reticulum membrane protein, 2.2606 may facilitate protein-protein interactions between the Erg26p dehydrogenase and the YPR026W YAR066W YBR132C YMR046WA YIL030C YPL205C ATH1 SSM4 2.2427 2.2399 YLR256W HAP1 2.2389 YDL215C YOL100W YFR047C YNL034W YBR001C YCL042W YER062C GDH2 PKH2 BNA6 HOR2 2.2385 2.2347 2.2315 2.2285 2.2278 2.2263 2.2245 YNL250W RAD50 2.2228 YJR039W YMR087W YLL058W YEL035C YPL035C YOL002C YNR077C YKL091C YJR004C YFL011W AGP2 2.2570 2.2532 2.2472 2.2446 NTH2 SAG1 HXT10 2.2221 2.2212 2.2147 2.2146 2.2146 2.2135 2.2125 2.2101 2.2098 2.2092 YAR027W UIP3 2.2081 YER119C YFR003C YNL155W YER035W YLR280C YBR012C YNR062C YLL065W AVT6 YPI1 2.2060 2.2004 2.1995 2.1990 2.1977 2.1961 2.1908 2.1905 UTR5 EDC2 Erg27p 3-ketoreductase and/or tether these enzymes to the ER Acid trehalase Hypothetical ORF Plasma membrane carnitine transporter Similar to probable membrane protein YLR334C and ORF YOL106W Integral membrane protein Hypothetical ORF Zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type NAD-dependent glutamate dehydrogenase Pkb-activating Kinase Homologue Quinolinate phosphoribosyl transferase Hypothetical ORF Neutral trehalase Hypothetical ORF DL-glycerol-3-phosphatase Mre11-Rad50-Xrs2 protein complex member involved in joining double-stranded breaks and DNA recombination Hypothetical ORF Hypothetical ORF Hypothetical ORF Product of gene unknown Hypothetical ORF Involved in PHO signaling pathway Hypothetical ORF Sec14p homolog Alpha-agglutinin High affinity hexose transporter Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Asp, Glu transporter PP1 phosphatase inhibitor Hypothetical ORF Enhancer of mRNA Decapping Hypothetical ORF Hypothetical ORF Hypothetical ORF Growth inhibitor YPL206C YGL121C 2.1880 GPG1 2.1818 YDR506C 2.1813 YPL017C 2.1794 Endoplasmic reticulum protein of unknown function Heterotrimeric G protein gamma subunit mimic Hypothetical ORF Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family 26S protease subunit component (putative)|ATPase Histone acetyltransferase 6-O-methylguanine-DNA methylase Hypothetical ORF Hypothetical ORF Suppressor of Exocyst Mutations; Homolog of DSS1; similar to hypothetical protein from S. pombe Hypothetical ORF very low affinity methionine permease Arginine specific|carbamoyl phosphate synthetase Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Hypothetical ORF Endochitinase Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange Hypothetical ORF c-terminal TMD|integral membrane protein YKL145W RPT1 2.1749 YPR193C YDL200C YIL055C YIL067C HPA2 MGT1 2.1733 2.1732 2.1728 2.1720 SEM1 2.1719 YLR279W YHL036W MUP3 2.1695 2.1691 YOR303W CPA1 2.1652 YNL279W PRM1 2.1632 YKL224C YLR286C CTS1 2.1555 2.1549 YKR046C PET10 2.1539 PEP12 2.1538 2.1529 HOR7 2.1513 Hyperosmolarity-responsive gene FUN34 PRE2 DNF2 2.1509 2.1502 2.1473 2.1468 YDR363WA YPR197C YOR036W YMR251WA YOR389W YNR002C YPR103W YDR093W Hypothetical ORF Transmembrane protein (putative) Proteasome subunit Potential aminophospholipid translocase YDR210W 2.1467 YMR271C YMR170C URA10 ALD2 2.1429 2.1396 YBR046C ZTA1 2.1392 YNL074C YOR227W MLF3 2.1337 2.1329 YNL200C YCL026C-A 2.1313 FRM2 2.1301 YOR235W YHR190W YKL133C ERG9 2.1292 2.1284 2.1257 YOR035C SHE4 2.1238 YML128C MSC1 2.1237 YPL080C 2.1234 YFL033C RIM15 2.1231 YGR135W YMR180C YOL136C PRE9 CTL1 PFK27 2.1231 2.1210 2.1207 YGL186C TPN1 2.1204 YLR216C CPR6 2.1203 YER096W YCL026C-B SHC1 2.1176 2.1173 YER053C YER018C YCR089W 2.1146 SPC25 FIG2 2.1140 2.1136 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Orotate phosphoribosyltransferase 2 aldeyhde dehydrogenase Zeta-crystallin homolog, has similarity to E. coli quinone oxidoreductase and human zeta-crystallin which has quinone oxidoreductase activity Protein of unknown function Hypothetical ORF Hypothetical ORF; similarity to human TGR-CL10C, thyroidal receptor for N-acetylglucosamine Protein involved in the integration of lipid signaling pathways with cellular homeostatis Hypothetical ORF Squalene synthetase Hypothetical ORF Required for mother cell-specific HO expression Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc1 mutants are defective in directing meiotic recombination events to homologous chromatids Hypothetical ORF Trehalose-associated protein kinase related to S. pombe cek1+ Proteasome component Y13 RNA triphosphatase 6-phosphofructo-2-kinase Plasma membrane pyridoxine transport protein cyclophilin 40|peptidyl-prolyl cis-trans isomerase (PPIase) sporulation-specific protein similar to Skt5p Hypothetical ORF Sequence similarity to mitochondrial phosphate transporters Spindle pole component GPI-anchored cell wall protein (putative) YOR255W YLR144C ACF2 YDR502C SAM2 YOR321W PMT3 YIL166C YNL336W COS1 YOR186W YMR173W DDR48 YAL034C YKL147C YPL170W YEL072W FUN19 YDR032C PST2 DAP1 RMD6 YMR173WA YGR065C VHT1 YOR212W STE4 YKL052C ASK1 YPL223C GRE1 YMR008C PLB1 2.0785 Hypothetical ORF YDL222C YDR171W HSP42 YKR011C YJR161C 2.1119 Outer Spore Wall Glucan-hydrolyzing protein that specifically acts on 1,3-beta linkages, with an endolytic 2.1091 mode of action. necessary for actin polymerization in permeabilized cells. 2.1048 Methionine biosynthesis regulation Dolichyl phosphate-D-mannose:protein 2.1028 O-D-mannosyltransferase Hypothetical ORF, member of the Dal5p 2.1003 subfamily of the major facilitator family Protein of unknown function, member of a 2.0944 family of conserved, often subtelomerically-encoded proteins 2.0942 Hypothetical ORF Contains >35 repeats of the amino acid 2.0941 sequence NNNDSYGS|flocculent specific protein 2.0889 Protein of unknown function 2.0852 Hypothetical ORF 2.0836 sterol-binding protein (putative) 2.0830 Required for Meiotic nuclear Division Protoplasts-SecreTed protein; the gene 2.0820 product was detected among the proteins secreted by regenerating protoplasts COS5 2.0782 H+-biotin symporter G protein beta subunit|coupled to mating 2.0776 factor receptor 2.0754 Associated with Spindles and Kinetochores Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock 2.0734 and heavy metals); regulated by the HOG pathway 2.0697 Phospholipase B (lypophospholipase) The authentic, non-tagged protein was 2.0674 localized to the mitochondria; cell cortex protein Similar to HSP26; expression is regulated by 2.0667 stress conditions 2.0639 Hypothetical ORF Protein of unknown function, member of a 2.0634 family of conserved, often YDR453C TSA2 2.0633 YGL216W YOR011W YJL077C KIP3 AUS1 ICS3 2.0618 2.0596 2.0589 YLR270W DCS1 2.0543 YBR148W YER103W YHR145C YSW1 SSA4 2.0515 2.0509 2.0490 YMR189W GCV2 2.0470 YMR151W YIM2 2.0467 YHR124W NDT80 2.0443 YKR097W YDL124W PCK1 2.0416 2.0414 YDR513W TTR1 2.0361 YCR030C YDL128W YLR080W SYP1 VCX1 EMP46 2.0358 2.0358 2.0341 YKL065C 2.0335 YDR122W KIN1 2.0328 YDR283C GCN2 2.0319 YJL206C YLR312C YGR248W YHR214W YGR049W YKR106W SOL4 SCM4 2.0313 2.0305 2.0289 2.0267 2.0247 2.0243 subtelomerically-encoded proteins Thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl hydroperoxides with the use of hydrogens provided by thioredoxin, thioredoxin reductase, and NADPH|EC 1.11.1.Kinesin-related protein ATP-binding cassette (ABC) family Protein of unknown function Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity andJa HIT (histidine triad)Jmotif; interacts with neutral trehalase Nth1pJJ Spore-specific protein HSP70 family Hypothetical ORF Glycine cleavage system P subunit|glycine decarboxylase complex P subunit|glycine synthase P subunit Product of gene unknown DNA binding transcription factor that activates middle sporulation genes Phosphoenolpyruvate carboxylkinase Hypothetical ORF glutaredoxin|thioltransferase/glutathione reductase|EC 1.20.4.1 Suppressor of Yeast Profilin deletion vacuolar H+/Ca2+ exchanger homolog of the Golgi protein Emp47p Yeast endoplasmic reticulum 24 kDa transmembrane protein Serine/threonine protein kinase Eukaryotic initiation factor 2 alpha (eIF2-alpha) kinase Hypothetical ORF Hypothetical ORF 6-phosphogluconolactonase Putative membrane protein Protein that suppresses ts allele of CDC4 when overexpressed Hypothetical ORF YBR299W YLR174W YKR053C YDR335W MAL32 IDP2 YSR3 MSN5 2.0238 2.0232 2.0198 2.0184 YMR139W RIM11 2.0148 YOR092W YKL146W YNL280C YBL041W YOR084W ECM3 AVT3 ERG24 PRE7 2.0134 2.0114 2.0107 2.0106 2.0102 YGR037C ACB1 2.0099 YMR276W YML131W YGR284C YKL070W DSK2 2.0058 2.0054 2.0039 2.0016 YBR214W SDS24 YPR124W CTR1 -12.5488 YOL152W FRE7 -12.2951 YGR144W THI4 -11.2966 YDL241W YHR128W FUR1 -9.3779 -8.0710 YNL112W DBP2 -7.0214 ERV29 YPR123C 2.0010 -6.6529 YNL141W AAH1 -6.6065 YDR399W HPT1 -5.7893 YPL058C YLR004C YMR326C YGR293C YOR004W PDR12 -5.5090 -5.5043 -5.1049 -4.9925 -4.8400 YCR020C PET18 -4.8092 Maltase NADP-dependent isocitrate dehydrogenase DHS-1-P phosphatase Multicopy suppressor of snf1 mutation Required for Ime1p phosphorylation, association of the Ime1p-Ume6p meiotic activator, early meiotic gene expression, and sporulation ExtraCellular Mutant Gln (Asn), Ile (Leu), Tyr transporter Sterol C-14 reductase proteasome subunit acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI)/endozepine (EP) ubiquitin-like protein Hypothetical ORF ER-Golgi transport vesicle protein Hypothetical ORF Similar to S. pombe SDS23, suppresses DIS2, localized to the nucleus Copper transport protein Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels but not by low iron levels biosynthetic pathway component producing the thiazole precursor of thiamine Hypothetical ORF UPRTase ATP dependent RNA helicase|dead box protein Hypothetical ORF Adenine aminohydrolase (adenine deaminase) Hypoxanthine guanine phosphoribosyltransferase Multidrug resistance transporter Hypothetical ORF Hypothetical ORF Hypothetical ORF Protein required for cell viability Protein required for respiratory growth and stability of the mitochondrial genome YFR055W YGR021W YIL119C YLR237W YLR214W YBR238C YDL182W RPI1 THI7 FRE1 LYS20 YJL218W YOR342C -4.7865 -4.7753 -4.7531 -4.7428 -4.6440 -4.4464 -4.3328 -4.3186 -4.2082 Hypothetical ORF Hypothetical ORF Ras inhibitor Thiamine transporter Cupric reductase|ferric reductase Hypothetical ORF YDL131W (LYS21) homolog|homocitrate synthase Hypothetical ORF Hypothetical ORF Snooze: stationary phase-induced gene family Nuclear localization sequence binding protein Hypothetical ORF Translation initiation factor eIF3 subunit Putative transmembrane domain protein involved in cell wall biogenesis histone H2A (HTA1 and HTA2 code for nearly identical proteins) transcriptional activator protein of CYC1 (component of HAP2/HAP3 heteromer) Protein that binds to the C-terminal domain of Hyp2p (eIF5A); has four to five HEAT-like repeats Hypothetical ORF Hypothetical ORF Malic enzyme Purine-cytosine permease Multicopper oxidase Isocitrate dehydrogenase 1 alpha-4-beta-4 subunit Hypothetical ORF Iso-1-cytochrome c YFL059W SNZ3 -4.1843 YGR159C YBR025C YBR079C NSR1 RPG1 -4.1661 -4.1538 -4.1105 YAL059W ECM1 -3.9355 YBL003C HTA2 -3.8144 YKL109W HAP4 -3.8032 YJR070C LIA1 -3.7979 YLR296W YBR300C YKL029C YER056C YMR058W MAE1 FCY2 FET3 -3.7967 -3.7685 -3.6538 -3.6392 -3.6301 YNL037C IDH1 -3.6053 CYC1 -3.5682 -3.5635 FCY22 -3.5138 purine-cytosine permease YGR160W YJR048W YER060WA YIL019W YOR272W YTM1 YPR100W MRPL51 YFL060C SNO3 -3.4930 Protein required for cell viability -3.4728 Microtubule-associated protein Mitochondrial ribosomal protein of the large -3.4713 subunit Protein of unknown function, nearly identical to Sno2p; expression is induced before the -3.4578 diauxic shift and also in the absence of thiamin YOR095C RKI1 YDL051W LHP1 YBR092C YHR061C PHO3 GIC1 YDR033W MRH1 YGR109C YOR101W CLB6 RAS1 YOR108W LEU9 YLR449W YER001W YDR375C FPR4 MNN1 BCS1 YDL205C HEM3 YNL175C NOP13 YML056C IMD4 YLR168C YDR021W FAL1 YOL124C YPR145W ASN1 YOL055C THI20 YFR056C YDR277C YDR534C YNL174W MTH1 FIT1 -3.4553 Ribose-5-phosphate ketol-isomerase Protein homologous to human La (SS-B) -3.4480 autoantigen -3.4417 Acid phosphatase -3.4144 Gtpase-interacting component 1 Membrane protein related to Hsp30p; Localized by immunofluorescence to membranes, mainly the plasma membr. -3.4127 punctuate immunofluorescence pattern observed in buds. The nuclear envelope, but not vacuole or mitochondrial membranes also stained -3.4112 B-type cyclin -3.3774 ras homolog Alpha-isopropylmalate synthase -3.3665 (2-isopropylmalate synthase) -3.3546 Peptidyl-prolyl cis-trans isomerase (PPIase) -3.3110 Alpha-1,3-mannosyltransferase -3.3059 ATPase (AAA family) Phorphobilinogen deaminase -3.3029 (uroporphyrinogen synthase) Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA -3.3023 recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA -3.2934 IMP dehydrogenase homolog Possibly involved in intramitochondrial -3.2505 sorting -3.2247 RNA helicase (putative)|dead box protein Putative S-adenosylmethionine-dependent -3.2155 methyltransferase of the seven beta-strand family -3.2041 asparagine synthetase THI for thiamine metabolism. Transcribed in the presence of low level of thiamine -3.1914 (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. -3.1774 Hypothetical ORF -3.1591 Msn3p homolog (61% identical) -3.1212 Cell wall protein involved in iron uptake -3.1171 Hypothetical ORF YMR006C YNL220W YOR203W YDL060W YBL039C YJL033W YLR073C YGR108W YHR020W PLB2 ADE12 YBR240C THI2 -3.0043 YDL050C YOR315W YLR269C YDR226W ADK1 -2.9826 -2.9715 -2.9685 -2.9368 YNL333W SNZ2 -2.9037 YCR087C-A YJL122W YOR248W YML087C YPL199C YKL078W DHR2 -2.8990 -2.8801 -2.8744 -2.8693 -2.8602 -2.8596 YLR074C BUD20 -2.8425 YOR282W YMR319C YHR066W FET4 SSF1 -2.8086 -2.7919 -2.7898 YGL053W PRM8 -2.7853 YBL029W YKL132C RMA1 -2.7771 -2.7726 YHR049W FSH1 -2.7724 YDR322W MRPL35 -2.7704 YGR061C ADE6 -2.7680 YKL030W TSR1 URA7 HCA4 CLB1 -3.1027 -3.0893 -3.0757 -3.0721 -3.0533 -3.0513 -3.0359 -3.0353 -3.0099 -2.7440 Lysophospholipase|phospholipase B Adenylosuccinate synthetase Protein required for cell viability Twenty S rRNA accumulation CTP synthase RNA helicase (putative) Hypothetical ORF B-type cyclin Protein required for cell viability Transcriptional activator of thiamine biosynthetic genes Hypothetical ORF Hypothetical ORF Hypothetical ORF Adenylate kinase Snooze: stationary phase-induced gene family Hypothetical ORF Hypothetical ORF Hypothetical ORF Hypothetical ORF Hypothetical ORF Required for 18S ribosomal RNA synthesis Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Protein required for cell viability low affinity Fe2+ transport protein Ssf2p homolog Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER Hypothetical ORF probable folyl-polyglutamate synthetase Serine hydrolase that localizes to both the nucleus and cytoplasm. Sequence similary to Fsh2p and Fsh3p Mitochondrial ribosomal protein of the large subunit 5-phosphoribosylformyl glycinamidine synthetase Hypothetical ORF YNR066C YDR496C YGR234W YAL025C PUF6 YHB1 MAK16 YMR049C ERB1 YDL062W YPL092W YMR290WA YPR144C SSU1 -2.7409 -2.7393 -2.7303 -2.7165 Hypothetical ORF Member of the PUF protein family flavohemoglobin Nuclear protein (putative) Protein required for maturation of the 25S -2.7077 and 5.8S ribosomal RNAs; homologous to mammalian Bop1 -2.7075 Hypothetical ORF -2.6972 major facilitator superfamily -2.6961 Protein required for cell viability NOC4 YHR062C RPP1 YOR242C SSP2 YBR061C TRM7 YLR196W PWP1 YPL093W NOG1 YML027W YOX1 YIL036W CST6 YNL334C SNO2 YJL217W YMR120C ADE17 YPL256C YGR145W YHR052W CLN2 YGL078C DBP3 YMR081C ISF1 YJL096W MRPL49 CIC1 -2.6783 U3 snoRNP protein Nuclear ribonuclease P (RNase P) protein -2.6632 subunit -2.6585 Sporulation SPecific 2-O-ribose tRNA anticodon loop -2.6458 methyltransferase Periodic tryptophan proteinProtein with periodic trytophan residues that resembles -2.6439 members of beta-transducin superfamily because of presence of WD-40 repeats Homologs identified in human and -2.6330 Trypanosoma brucei|nucleolar G-protein (putative) -2.6302 Homeobox-domain containing protein basic leucine zipper (bZIP) transcription -2.6236 factor Protein of unknown function, nearly identical to Sno3p; expression is induced before the -2.6104 diauxic shift and also in the absence of thiamin -2.6061 Hypothetical ORF 5-aminoimidazole-4-carboxamide -2.5958 ribonucleotide (AICAR) transformylase/IMP cyclohydrolase -2.5938 G1 cyclin -2.5915 Essential protein of unknown function -2.5775 Core interacting component 1 ATP dependent RNA helicase|dead/deah box -2.5753 protein CA3 May regulate NAM7 function, possibly at -2.5730 level of mRNA turnover -2.5712 Mitochondrial ribosomal protein of the large YKL016C YIL096C YER188W ATP7 -2.5708 -2.5565 -2.5545 YGR165W MRPS35 -2.5544 YBR093C YDR324C YLR395C PHO5 UTP4 COX8 -2.5535 -2.5507 -2.5451 YNL151C RPC31 -2.5451 YPL132W COX11 -2.5423 YLL018C-A COX19 -2.5411 YPL266W YJL208C YML094C-A YKR039W YDR321W DIM1 NUC1 -2.5345 -2.5209 -2.5176 -2.5110 -2.5077 GAP1 ASP1 YOL007C YGL171W -2.5061 ROK1 -2.5024 YLR063W YJL148W YPR010C YKL056C RPA34 RPA135 -2.4990 -2.4974 -2.4965 -2.4929 YER006W NUG1 -2.4884 YLR365W YIL070C MAM33 -2.4883 -2.4851 YJL025W RRN7 -2.4772 YLR397C YHR169W YFR035C YBR271W AFG2 DBP8 -2.4768 -2.4666 -2.4618 -2.4516 subunit ATP synthase d subunit Hypothetical ORF Hypothetical ORF Mitochondrial ribosomal protein of the small subunit Acid phosphatase U3 snoRNP protein Cytochrome c oxidase chain VIII HMG1-like protein|RNA polymerase III (C) 31 kDa subunit Mitochondrial membrane protein required for assembly of active cytochrome c oxidase, probably involved in insertion of Cu(B) and magnesium Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase Dimethyladenosine transferase Nuclease Hypothetical ORF General amino acid permease Asparaginase I|intracellular isozyme Appears to be a structural component of the chitin synthase 3 complex ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis Hypothetical ORF RNA polymerase I subunit A34.5 RNA polymerase I subunit Hypothetical ORF Nuclear GTPase involved in Ribosome biogenesis Hypothetical ORF 33-kDa mitochondrial acidic matrix protein yeast Pol I core factor (CF) also composed of Rrn11p, Rrn6p and TATA-binding protein Similar to the CDC48 gene product Dead box protein Hypothetical ORF Putative S-adenosylmethionine-dependent YFL017W-A SMX2 YBL031W SHE1 -2.4502 -2.4468 YBL090W -2.4437 MRP21 YHL013C YOR206W -2.4428 NOC2 YIL025C -2.4401 -2.4400 methyltransferase of the seven beta-strand family snRNP G protein (human Sm-G homolog) Product of gene unknown Mitochondrial ribosome small subunit component Hypothetical ORF Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors Hypothetical ORF Responsible for most, if not all, m(1)G(9) modification of tRNAs. Mitochondrial ribosome recycling factor RiboSome Assembly 2 Protein tyrosine phosphatase induced by nitrogen starvation Ribosomal protein S5 (putative) 14 kDa mitochondrial ribosomal protein|similar to E. coli S14 protein Heat shock transcription factor homolog Malate dehydrogenase Coiled-coil protein Protein required for cell viability SnRNP protein Hypothetical ORF Hypothetical ORF Mitochondrial ribosomal protein of the large subunit Ribosomal protein S9A (S13) (rp21) (YS11) Hypothetical ORF Ribonuclease III YOL093W TRM10 -2.4337 YHR038W YMR131C RRF1 RRB1 -2.4305 -2.4299 YIR026C YVH1 -2.4199 YBR251W MRPS5 -2.4170 YPR166C MRP2 -2.4133 YJR147W YKL085W YGL029W YPL251W YJR022W YCR087W YHL008C HMS2 MDH1 CGR1 -2.4115 -2.4073 -2.4064 -2.4056 -2.4049 -2.4015 -2.3969 YKR085C MRPL20 -2.3939 YPL081W YOL014W YMR239C YKR081C YLR445W YOL077WA YPR041W YER070W YBR120C YNL300W RPS9A -2.3934 -2.3904 -2.3891 -2.3771 -2.3769 Hypothetical ORF LSM8 RNT1 RPF2 ATP19 -2.3646 ATP synthase subunit k homolog TIF5 RNR1 CBP6 -2.3640 -2.3623 -2.3589 -2.3561 Translation initiation factor eIF5 Ribonucleotide reductase, large (R1) subunit Translational activator of COB mRNA Hypothetical ORF YHR183W GND1 -2.3552 YHR092C YGR245C HXT4 SDA1 -2.3502 -2.3501 YOR224C RPB8 -2.3486 YOR135C -2.3484 YHR085W -2.3338 YGL055W YDL063C OLE1 -2.3332 -2.3279 YJL158C CIS3 -2.3241 YNL291C MID1 -2.3185 YDR060W MAK21 -2.3165 YDL181W Q0045 INH1 COX1 -2.3121 -2.3060 YBR161W CSH1 -2.3056 YNR053C NOG2 -2.3040 YAR028W -2.3036 YDL055C PSA1 -2.3009 YGR169C YCR046C PUS6 IMG1 -2.2977 -2.2973 YNL061W NOP2 -2.2926 YDR120C TRM1 -2.2891 YLR265C YKL131W NEJ1 -2.2888 -2.2846 6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2 High affinity glucose transporter Severe Depolymerization of Actin 16 kDa RNA polymerase subunit (common to polymerases I, II and III) Hypothetical ORF Protein of unknown function, essential for viability, may be involved in rRNA processing Delta-9-fatty acid desaturase Hypothetical ORF Similar to Hsp150p and Pir1p, Pir2p, and Pir3p N-glycosylated integral plasma membrane protein Essential for 60s ribosome biogenesis; involved in nuclear export of pre-ribosomes ATPase inhibitor Cytochrome c oxidase subunit I Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p part of a pre-60S complex Putative integral membrane protein, member of DUP240 gene family GDP-mannose pyrophosphorylase|mannose-1-phosphate guanyltransferase RNA:Psi-synthase mitochondrial ribosomal protein 90 kDa protein homologous to a human proliferation-associated nucleolar protein, p120 N2,N2-dimethylguanosine-specific tRNA methyltransferase Mating-type regulated component of NHEJ Hypothetical ORF YHL004W MRP4 -2.2773 YCR098C GIT1 -2.2756 YMR217W YHR148W YNL110C YNL017C YOR146W GUA1 IMP3 NOP15 -2.2746 -2.2685 -2.2681 -2.2652 -2.2612 YPL252C YAH1 -2.2605 YGL129C RSM23 -2.2586 YDR087C RRP1 -2.2584 YGL117W -2.2568 YCL058C FYV5 -2.2560 YER110C YGR123C KAP123 PPT1 -2.2556 -2.2475 YDR299W BFR2 -2.2443 YNR018W YIL122W YOR334W POG1 MRS2 -2.2438 -2.2435 -2.2421 YLR160C ASP3-4 -2.2420 YOL164W YHR033W -2.2415 -2.2403 YML009C MRPL39 -2.2403 YCR003W YPL267W YIL082W MRPL32 -2.2382 -2.2355 -2.2351 YLL053C YMR290C YOR246C -2.2325 HAS1 -2.2322 -2.2284 Mitochondrial ribosomal protein|mitochondrial ribosome 37 S subunit component|similar to E. coli ribosomal protein S2 Permease involved in the uptake of glycerophosphoinositol (GroPIns) GMP synthase U3 snoRNP protein Ribosome biogenesis Hypothetical ORF Protein required for cell viability Iron-sulfur protein similar to human adrenodoxin ATPase (putative)|mitochondrial ribosome small subunit component Involved in processing rRNA precursor species to mature rRNAs Hypothetical ORF Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Karyopherin beta 4 Serine/threonine phosphatase Involved in protein transport step at the Brefeldin A blocks Hypothetical ORF Transcription factor (putative) magnesium ion transporter Nitrogen catabolite-regulated cell-wall L-asparaginase II Hypothetical ORF Hypothetical ORF Mitochondrial ribosomal protein of the large subunit Ribosomal protein (YmL32) Hypothetical ORF Hypothetical ORF Hypothetical ORF; maybe continuous with YLL052C (AQY2) in some strain backgrounds including Sigma1278b; functions as an aquaporin in these strains. RNA-dependent helicase (putative) Hypothetical ORF YLL044W YGR208W YHR089C YBL100C SER2 GAR1 -2.2263 -2.2233 -2.2205 -2.2193 YDR083W RRP8 -2.2185 YDR041W RSM10 -2.2182 YOL077C BRX1 -2.2170 YDR465C YOR314W YCR006C YNL296W YJR077C YGR273C YLR212C YLR432W RMT2 TUB4 IMD3 -2.2168 -2.2092 -2.2075 -2.2049 -2.2031 -2.2011 -2.2005 -2.1993 YLR175W CBF5 -2.1983 YOR310C NOP58 -2.1980 MIR1 YIL080W -2.1951 YOR375C GDH1 -2.1903 YHR093W AHT1 -2.1871 YLL009C YOR294W YOL022C COX17 RRS1 -2.1802 -2.1801 -2.1772 YKR080W MTD1 -2.1762 YOR271C -2.1721 YGR082W TOM20 -2.1719 YMR193W MRPL24 -2.1717 Hypothetical ORF Phosphoserine phosphatase Small nucleolar RNP protein Sporulation Nucleolar protein required for efficient processing of pre-rRNA at site A2; methyltransferase homolog Mitochondrial ribosome small subunit component Essential nucleolar protein required for biogenesis of the 60S ribosomal subunit Arginine methyltransferase Hypothetical ORF Hypothetical ORF Hypothetical ORF Product of gene unknown Hypothetical ORF Gamma tubulin IMP dehydrogenase homolog Major low affinity 55 kDa centromere/microtubule binding protein U3 snoRNP protein TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition NADP-specific glutamate dehydrogenase The AHT1 DNA sequence is upstream of HXT4 and contains an HXT4 regulatory element which is a multicopy suppressor of glucose transport defects; probable non-functional ORF Cysteine-rich protein Regulator for ribosome synthesis Protein required for cell viability NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase Hypothetical ORF 20 kDa mitochondrial outer membrane protein import receptor Mitochondrial ribosomal protein of the large subunit YLR295C YGL120C YDR398W ATP14 PRP43 UTP5 YOR187W TUF1 YBR291C YJL010C CTP1 YPL214C THI6 YLR406C RPL31B YOL109W ZEO1 YDR347W MRP1 YIL064W YPR136C YNR036C YPL173W MRPL40 YIL093C RSM25 YIR021W MRS1 YPL124W SPC29 YHR170W NMD3 YNL284C MRPL10 YOL069W NUF2 YBR268W MRPL37 YJL125C GCD14 YPR119W YOR091W YCL024W CLB2 KCC4 -2.1680 ATP synthase subunit h -2.1659 RNA helicase -2.1659 U3 snoRNP protein Translation elongation factor Tu, -2.1627 mitochondrial -2.1619 Citrate tranporter -2.1617 Protein required for cell viability TMP -2.1616 pyrophosphorylase|hydroxyethylthiazole kinase -2.1614 ribosomal protein L31B (L34B) (YL28) Peripheral membrane protein of the plasma membrane that interacts with Mid2p; -2.1604 regulates the cell integrity pathway mediated by Pkc1p and Slt2p -2.1591 37 kDa mitochondrial ribosomal protein Putative S-adenosylmethionine-dependent -2.1591 methyltransferase of the seven beta-strand family -2.1587 Hypothetical ORF -2.1555 Hypothetical ORF Mitochondrial ribosomal protein of the large -2.1537 subunit Mitochondrial ribosome small subunit -2.1523 component RNA splicing protein of the mitochondrial -2.1490 carrier (MCF) family -2.1489 Spindle pole body component Factor required for a late assembly step of the -2.1434 60S subunit Mitochondrial ribosomal protein of the large -2.1432 subunit Spindle pole body protein, required for chromosome segregation during mitosis; part -2.1428 of a centromeric complex along with Tid3p, Spc25p, and Spc24p Mitochondrial ribosomal protein of the large -2.1407 subunit Subunit of tRNA(1-methyladenosine) -2.1401 methyltransferase, along with Gcd10p -2.1384 B-type cyclin -2.1381 Hypothetical ORF -2.1378 S. pombe Nim1 homolog|protein kinase YIL127C YPL013C MRPS16 YER126C NSA2 YKL191W DPH2 YDR023W SES1 YCL063W VAC17 YHR059W FYV4 YLR156W YBL028C YLR157C-B YHR149C YHL009WA YKR013W PRY2 YOL125W YCR019W MAK32 YOL052C YNL142W SPE2 MEP2 YOR335C ALA1 YDL037C BSC1 YMR128W ECM16 -2.1367 Hypothetical ORF Mitochondrial ribosomal protein of the small -2.1355 subunit -2.1349 Ribosome biogenesis Protein of unknown function, involved in -2.1317 diphtheria toxicity and diphthamide biosynthesis, not essential for viability -2.1307 Serine-tRNA ligase the vacuole-specific receptor of Myo2p, a -2.1303 class V myosin Protein of unknown function, required for -2.1286 survival upon exposure to K1 killer toxin Note: YLR156W, YLR159W, and -2.1241 YLR161W are identical. -2.1239 Hypothetical ORF TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN -2.1226 proteins that are required for retrotransposition Protein of unknown function found in the bud -2.1220 tip and bud neck, potential Cdc28p substrate TyA Gag protein; the main structural -2.1193 constituent of virus-like particles (VLPs) Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% -2.1167 identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein. -2.1132 Hypothetical ORF Protein necessary for structural stability of -2.1112 L-A double-stranded RNA-containing particles -2.1108 S-adenosylmethionine decarboxylase -2.1078 ammonia transport protein Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation -2.1076 (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog Bypass of Stop Codon transcript encoded by -2.1038 this ORF shows a high level of stop codon bypass -2.1037 U3 snoRNP protein YGR151C YML060W YDR449C YHR064C OGG1 UTP6 SSZ1 -2.1017 -2.1014 -2.0998 -2.0991 YGR103W NOP7 -2.0944 YDR278C YNL217W YLR434C YBL013W YML120C FMT1 NDI1 -2.0939 -2.0935 -2.0920 -2.0913 -2.0909 YGR174C CBP4 -2.0899 YKL081W TEF4 -2.0892 YPL211W NIP7 -2.0861 YGL068W YCR057C PWP2 -2.0854 -2.0843 YPR037C ERV2 -2.0772 DCD1 -2.0766 -2.0761 YLL022C YHR144C Q0075 AI5_BET A -2.0757 YNL173C MDG1 -2.0752 YGR251W -2.0698 YBL045C COR1 -2.0689 YOR361C YGR291C YGR288W YBL054W YNL248C PRT1 RPA49 -2.0684 -2.0656 -2.0643 -2.0635 -2.0611 YLR029C RPL15A -2.0604 YJL050W MTR4 -2.0598 MAL13 Hypothetical ORF 43 kDa 8-oxo-guanine DNA glycosylase U3 snoRNP protein HSP70 family Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles Hypothetical ORF Hypothetical ORF Hypothetical ORF Methionyl-tRNA transformylase NADH dehydrogenase (ubiquinone) Essential for the expression and activity of ubiquinol-cytochrome c reductase Translation elongation factor EF-1gamma Nip7p is required for 60S ribosome subunit biogenesis Protein required for cell viability U3 snoRNP protein Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Hat1 Interacting Factor 1 dCMP deaminase Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG Multicopy suppressor of bem1 mutation, may be involved in G-protein mediated signal transduction; binds cruciform DNA Protein required for cell viability Coenzyme QH2 cytochrome c reductase 44 kDa core protein subunit Translation initiation factor eIF3 subunit Hypothetical ORF MAL-activator protein Hypothetical ORF RNA polymerase A 49 kDa alpha subunit Ribosomal protein L15A (YL10) (rp15R) (L13A) RNA helicase YAL003W YDR089W YGR272C EFB1 YKL138C MRPL31 YHR127W YDR405W MRP20 YJR047C ANB1 YNL252C MRPL17 YGR183C QCR9 YFR028C YLR312WA YPR020W YJR154W YKL183W YDL080C CDC14 YNL315C ATP11 YNL029C YIL083C KTR5 YPR112C MRD1 MRPL15 ATP20 LOT5 THI3 YPL257W-B YPR102C RPL11A YGR081C SLX9 YHR136C SPL2 -2.0569 Translation elongation factor EF-1beta -2.0539 Hypothetical ORF -2.0532 Hypothetical ORF Mitochondrial ribosomal protein of the large -2.0515 subunit (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4. Suppression is very -2.0475 specific to this allele. It has no affect on the analogous YPT1 allele. No homology or known function. 263 amino acid mitochondrial ribosomal -2.0468 large subunit|similar to L23 family of ribosomal proteins Translation initiation factor eIF-5A, -2.0464 anaerobically expressed form Mitochondrial ribosomal protein of the large -2.0451 subunit Ubiquinol cytochrome c oxidoreductase -2.0432 complex 7.3 kDa subunit 9 -2.0426 Protein phosphatase Mitochondrial ribosomal protein of the large -2.0418 subunit -2.0416 ATP synthase subunit g homolog -2.0403 Hypothetical ORF -2.0398 LOw Temperature responsive -2.0373 Alpha-ketoisocaproate decarboxylase Essential for assembly of a functional -2.0371 F1-ATPase; binds the beta subunit of F1-ATPase. -2.0335 Mannosyltransferase (putative) -2.0322 Homolog to human PPCS Multiple RNA Binding Domain; essential for -2.0321 synthesis of the small ribosomal subunit TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN -2.0294 proteins that are required for retrotransposition Ribosomal protein L11A (L16A) (rp39A) -2.0286 (YL22) Protein of unknown function; deletion mutant -2.0274 has synthetic fitness defect with an sgs1 deletion mutant -2.0272 Protein with similarity to cyclin-dependent YGL045W RIM8 -2.0254 YBR202W CDC47 -2.0248 YMR042W ARG80 -2.0237 YJL063C MRPL8 -2.0232 YGL143C MRF1 -2.0229 YDR225W HTA1 -2.0225 YHR088W RPF1 -2.0217 YPR074W-A YKL143W -2.0214 LTV1 -2.0211 YOR006C YDL031W YEL034W DBP10 HYP2 -2.0182 -2.0172 -2.0164 YEL050C RML2 -2.0150 YKL181W YPL255W PRS1 BBP1 -2.0105 -2.0083 YGL236C MTO1 -2.0079 YPL029W SUV3 -2.0058 YNL022C YJL168C a b -2.0057 SET2 -2.0026 kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Regulator of IME2 (RIM) Involved in proteolytic processing of Rim1p Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Transcription factor Mitochondrial ribosomal protein of the large subunit Mitochondrial polypeptide chain release factor Histone H2A (HTA1 and HTA2 code for nearly identical proteins) Protein that localizes to the nucleolus Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. Protein required for viability at low temperature Hypothetical ORF Dead box protein 10 Translation initiation factor eIF-5A mitochondrial ribosomal protein L2 of the large subunit Ribose-phosphate pyrophosphokinase Involved in mitotic cell cycle and meiosis Mitochondrial Translation Optimization; Strong similarity to E. coli GidA ATP dependent helicase (putative) Non-essential protein with similarity to S. pombe hypothetical protein E349594 Contains SET domain Genes with expression changes upon treatment with 64 µg of dictamnine per ml. Fold change refers to expression increases or decreases for upregulated or downregulated genes, respectively.