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Principal Investigator/Program Director (Last, first, middle):
DiCorleto, Paul E.
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Paul E. DiCorleto, Ph.D.
Chairman, Lerner Research Institute
eRA COMMONS USER NAME
PAULDICORLETO
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Rensselaer Polytechnic Inst., Troy, NY
Cornell University, Ithaca, N
University of Washington, Seattle, WA
DEGREE
(if applicable)
YEAR(s)
B.S.
Ph.D.
Postdoc
1973
1978
1978-81
FIELD OF STUDY
Chemistry
Biochemistry
Vascular Cell Biology
A. Positions and Honors:
Professional Positions
1981-1982
Project Scientist, Dept. of Cardiovascular Research, Cleveland Clinic Foundation
1982-1985
Associate Staff, Department of Cardiovascular Research, Cleveland Clinic Foundation
1985-1989
Staff, Department of Brain and Vascular Research, Cleveland Clinic Foundation
1985-present
Adjunct Faculty, Department of Biology, Cleveland State University
1989-present
Adjunct Faculty, Department of Biology, Case Western Reserve University
1992-present
Professor, Department of Molecular and Cellular Biochemistry, Ohio State University
1989-present
Professor, Department of Physiology and Biophysics, Case Western Reserve University
1996-1999
Vice Chair, Cleveland Clinic Lerner Research Institute
1997-2001
Associate Chief of Staff, Cleveland Clinic Foundation
1989-2002
Chairman, Department of Cell Biology, Cleveland Clinic Lerner Research Institute
2003-present
Chairman, Department of Molecular Medicine, Case School of Medicine
2002-present
Chairman, Lerner Research Institute, Cleveland Clinic Foundation
Awards and Other Professional Activities:
1985-1990: NIH Research Career Development Award; 1988: Co-Chair with Dr. S. Schwartz of First
Gordon Conference on Vascular Cell Biology; 1987-1991: Member and Chair, NIH Cellular Biology and
Physiology II Study Section; 1991: Visiting Scholar of the British Heart Fund; 1995-1999: Member, Heart,
Lung and Blood Program Project Review Committee, NHLBI; 1999- present: Member, Advisory Panel on
Research, Association of American Medical Colleges; 2001: American Heart Association Special
Recognition Award of the ATVB Council; 2002-2003: President, North American Vascular Biology
Organization
B. Selected Relevant Publications (from over 90):
DiCorleto, P.E. and Bowen-Pope, D.F. (1983). Cultured endothelial cells produce a platelet-derived growth factor-like
protein. Proc. Natl. Acad. Sci. 80: 1919-1923.
Morel, D.W., DiCorleto, P.E. and Chisolm, G.M. (1984) Endothelial and smooth muscle cells alter low density lipoprotein
in vitro by free radical oxidation. Arteriosclerosis 4: 357-364.
DiCorleto, P.E. and de la Motte, C.A. (1985) Characterization of the adhesion of the human monocytic cell line U937 to
cultured endothelial cells. J. Clin. Invest. 75: 1153-1161.
Fox, P.L. and DiCorleto, P.E. (1986) Modified low density lipoproteins suppress production of platelet-derived growth
factor by cultured endothelial cells. Proc. Natl. Acad. Sci. USA 83: 4774-4778.
Fox, P.L., Chisolm, G.M., and DiCorleto, P.E. (1987) Lipoprotein-mediated inhibition of endothelial cell production of
PDGF-like protein depends on free radical lipid peroxidation. J. Biol. Chem. 262: 6046-6054.
Fox, P.L. and DiCorleto, P.E. (1988) Fish oils inhibit endothelial cell production of platelet-derived growth factor-like
protein. Science 241: 453-456.
PHS 398/2590 (Rev. 09/04)
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, first, middle):
DiCorleto, Paul E.
DiCorleto, P.E. and de la Motte, C.A. (1989) Thrombin causes increased monocytic cell adhesion to endothelial cells
through a protein kinase C-dependent pathway. Biochem. J. 264: 71-77.
DiCorleto, P.E. and de la Motte, C.A. (1989) Role of cell surface carbohydrate moieties in monocytic cell adhesion to
endothelium in vitro. J. Immunol. 143: 3666-3672.
Shankar, R., de la Motte, C.A., and DiCorleto, P.E. (1992) Thrombin stimulates platelet-derived growth factor production
and monocyte adhesion through distinct intracellular pathways in human aortic EC. Am. J. Physiol. 262: C199-C206.
Shankar, R., de la Motte, C.A., and DiCorleto, P.E. (1992) 3-Deazaadenosine inhibits thrombin-stimulated PDGF
production and ELAM-1 mediated monocytic cell adhesion in human aortic EC. J. Biol. Chem. 267: 9376-9382.
Shankar, R., de la Motte, C.A., Poptic, E.J. and DiCorleto, P.E. (1994) Thrombin receptor-activating peptides differentially
stimulate PDGF production, monocytic cell adhesion and E-selectin expression in human umbilical vein endothelial
cells. J. Biol. Chem., 269: 13936-13941.
Chisolm, G.M., Ma, G., Irwin, K.C., Martin, L.L., Gunderson, K.G., Linberg, L.F., Morel, D.W., and DiCorleto, P.E. (1994)
7b-hydroperoxycholest-5-en-3b-ol, a component of human atherosclerotic lesions, is a primary cytotoxin of oxidized
human low density lipoprotein. Proc. Natl. Acad. Sci. USA , 91: 11452-11456.
Faruqi, R., de la Motte, C.A., and DiCorleto, P.E. (1994) a-Tocopherol inhibits agonist-induced monocytic cell adhesion to
cultured human endothelial cells. J. Clin. Invest., 94: 592-600.
Soyombo, A.A. and DiCorleto, P.E. (1994) Stable expression of human PDGF B chain by bovine aortic endothelial cells:
matrix association and selective proteolytic cleavage by thrombin. J. Biol. Chem., 269: 17734-17740.
Scarpati, E.M. and DiCorleto, P.E. (1996) Identification of a thrombin-response element in the human platelet-derived
growth factor B chain (c-sis) promoter. J. Biol. Chem., 271:3025-3032.
Faruqi, R.M., Poptic, E.J., Faruqi, T.R., de la Motte, C., and DiCorleto, P.E. (1997) Distinct mechanisms for Nacetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Am. J. Physiol., 273: H817-H826.
Faruqi, T.R. and DiCorleto, P.E. (1997) IFN-stranded RNA-induced E-selectin expression in human
endothelial cells. J. Immunol., 159: 3989-3994.
Faruqi, T.R., Erzurum, S.C., Kaneko, F.T., and DiCorleto, P.E. (1997) Role of nitric oxide in poly(I-C)-induced endothelial
cell expression of leukocyte adhesion molecules. Am. J. Physiol., 273: H2490-2497.
Van Heek, M., Schmitt, D., Toren, P., Cathcart, M.K., and DiCorleto, P.E., (1998) Cholesteryl HPODE from oxidized LDL
inactivates platelet-derived growth factor. J. Biol. Chem., 273: 19405-19410.
Patel, C., Sharangpani, R. Bandyopadhyay, S., and DiCorleto, P.E. (1999) Endothelial cells express a novel, TNF- -regulated
variant of HOXA9. J. Biol. Chem., 274:1415-1422.
Stenina, O. I., Poptic, E.J. and DiCorleto, P.E. (2000) Thrombin activates a Y box-binding protein (DNA-binding protein B) in
endothelial cells. J. Clin. Invest., 106, 579 - 587.
Guetta, E., Scarpati, E. and DiCorleto, P.E. (2001) The effect of cytomegalovirus immediate early gene products on
endothelial cell gene activity. Cardiovasc. Res., 50:538-46.
Mao, C.D., Hoang, P., and DiCorleto, P.E. (2001) Lithium inhibits cell cycle progression and induces stabilization of p53 in
bovine aortic endothelial cells. J. Biol. Chem., 276:26180-26188.
Stenina, O. I., Shaneyfelt, K., and DiCorleto, P.E. (2001) Thrombin induces the release of the Y-box protein dpbB from
mRNA: a new mode of transcription factor activation, Proc. Natl. Acad. Sci. USA, 98:7277-7282.
Byzova, T.V., Goldman, C.K., Jankau, J., Chen, J., Cabrera, G., Achen, M.G., Stacker, S.A., Carnevale, K.A., Siemionow M.,
Steven R. Deitcher S.R., and DiCorleto, P.E. (2002) Adenovirus encoding VEGF-D induces tissue-specific vascular
patterns in vivo. Blood, 99:4434-42.
Askari, A.T., Unzek, S., Popovic, Z.B., Goldman, C.K., Forudi, F., Kiedrowski, M., Rovner, A., Ellis, S.G., Thomas, J.T.,
DiCorleto, P.E., Topol, E.J., Penn, M.S. (2003) Effect of Stromal- cell-derived factor-1 on stem cell homing and tissue
regeneration in ischaemic cardiomyopathy. Lancet 362(9385):697-703.
Mazumder, B., Sampath, P., Seshadri, V., Maitra, R.K., DiCorleto, P.E. and Fox, P.L. (2003) Regulated release of L13a from
the 60S ribosomal subunit: A mechanism of transcript-specific translational control. Cell, 115:187-198.
Askari A, Unzek S, Goldman CK, Ellis SG, Thomas JD, DiCorleto PE, Topol EJ, Penn MS. (2004) Cellular, but not direct,
adenoviral delivery of vascular endothelial growth factor results in improved left ventricular function and
neovascularization in dilated ischemic cardiomyopathy J Am Coll Cardiol. 43:1908-14.
Tian, X., Kadaba,, R., You, S.-A., Liu, M., Timur, A.A., Yang, L., Chen, Q., Szafranski, P., Rao, S., Wu, L., Housman, D.E.,
DiCorleto, P.E., Driscoll, D.J., Borrow, J., and Wang, Q. (2004) Identification of an angiogenic factor that when
mutated cause susceptibility to Klippel-Trenaunay syndrome, Nature, 427:640-5.
Chandrasekharan, U.N., Yang, L., Walters, A., Howe, P.H. and DiCorleto, P.E. (2004) Role of CL-100, a dual specificity
phosphatase, in thrombin-induced endothelial cell activation. J. Biol. Chem., 279:46678-85.
PHS 398/2590 (Rev. 09/04)
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, first, middle):
DiCorleto, Paul E.
C. Research Support
Research Projects Ongoing or Completed During the Last Three Years:
“Regulation of Endothelial Cell Activation by Thrombin and Cytokines”: Project 4 of Program Project “Vascular
Cell Function and Atherosclerosis”
Principal Investigator: Paul E. DiCorleto, Ph.D., (P.I. of Program Project, of Project 4 & Cell Culture Core)
Agency: National Heart, Lung and Blood Institute
Type: P01 (HL29582, years 21 - 25) Period: 7/1/03 - 6/30/08
This project explores signaling pathways and transcription factors that play a role in EC expression of
activation genes in response to thrombin and TNF.
PHS 398/2590 (Rev. 09/04)
Page ____
Biographical Sketch Format Page