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ABSTRACT OF THE PAPER Physico–chemical and physiological studies of biological giant molecules with metal ions. Amino acids and its derivatives are fascinating valuable agents with many medicinal biological and industrial indications. So, investigations on the chemistry of such metals chelates of mixed amino-acids and L-Lysine monohydrochloride, physico-chemical and physiological studies, biological importance, medicinal uses will form the subject matter for this presentation. Interaction between LLysine monohydrochloride and glutamic acid with metal ions, Pb(11), As(11), Cd(11), Hg(11) & Cr(111) chelates. All the chelates have been isolated and their formulae determined on the basis of chemical analysis. The I.R. data molecular and molar conductance have been used to assign to the chelates. pH-metery, spectrophotometery and Xray studies have been carried out for those new chelates. Chelates of ligands and metal ions are synthisised and study of erythrocytes and homogenate of rats brain, kidney, Lungs Liver and muscle tissue were carried out. Complexes have been tested for their effect on biochemical parameters, viz enzyme activity, level of bioconstituents properties. The screening for hypoglycemic activity has been carried out in mice, chromium chelates formed by these ligands are useful in curing diabetes in mice, 25 to 30% fall in blood sugar has been reported. Chelating agents have been used as antidotes against metal poisonings, snake bites and various drugs to some extent. These Chelates can remove any toxic metal from the body. Hence we are keen to have tests on human & like system.