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Supplementary Table 8 Significant enrichment of immunological genes after electrotransfer with non-coding plasmid DNA. Enriched
GO terms for 421 probe-sets up-regulated 2-fold or more after electrotransfer with non-coding plasmid DNA only. To simplify representation,
only key nodes of the GO biological process tree (http://www.geneontology.org/) associated with immunological function are shown.
GO term ID
GO:0050896
Response to
stimulus
1.32 E-24
98
1949
Sample
frequency
(% pET
genes)
14.9%
GO:0002376
Immune system
process
4.51 E-55
80
716
19.3%
2.1%
GO:0050776
Regulation of
immune response
1.50e-22
26
137
6.3%
0.4%
GO:0006954
Inflammatory
response
8.15 E-16
25
223
6.0%
0.7%
GO:0045321
Leukocyte
activation
3.77 E-11
22
260
5.3%
0.8%
GO:0002250
Adaptive immune
response
4.48 E-19
22
113
5.3%
0.3%
GO:0045087
Innate immune
response
B cell mediated
immunity
Hemopoietic or
lymphoid organ
development
T cell activation
8.38 E-13
17
107
4.1%
0.3%
4.70e-15
17
80
4.1%
0.2%
3.43 E-05
16
281
3.9%
0.8%
7.10e-08
15
156
3.6%
0.5%
GO:0019724
GO:0048534
GO:0042110
GO term
Corrected
P value
# of pET
list
genes
Total # of
annotated
genes
Genome
frequency (%
genome
annotations)
1.3%
Annotated genes
Hck, Clec7a, Ccl9, Cd44, Tgtp, H2-Ab1, D3Ucla1, Oasl2, Tapbp, H2M3, H2-DMb1, Ifi47, Cxcl10, H2-T23, Lzp-s, Syk, Cfp, Neurl, H2-D1,
Cdkn1a, Serping1, Gbp2, Fcgr1, Gna13, Ifi27, Cxcl11, Cd47, Ifih1, H2K1, H2-DMa, Apoe, Tap1, Lsp1, Fcer1g, Stat1, C3ar1, Man2b1,
Pycard, C4b, Tap2, Sod3, Ccl5, Cd48, Coro1a, Anxa2, CD45, Psmb9,
Lyn, H2-Aa, Cd74, Slk, Irf8, Itgb2, Dbnl, Fn1, Lbp, C1qb, Mt1, C1qc,
Prkcd, Arrb2, Lyzs, Cxcl9, Tgfb1, Rsad2, Clec4a2, Cxcl14, Ly86, Lilrb3,
C1s, Irgm, Apobec1, Pnp, Cotl1, C3, B2m, Irf7, Thy1, Unc93b1, Mmp2,
F13a1, Rac2, C1qa, Cfb, Mest, Acp5, Serpina3g, Smad3, Fcgr2b, H2Eb1, Bre, Ccl6, Lst1, Ucp3, C1r, Cd14, Psmb8, Cd300d
Clec7a, Cd274, Ccl9, Sfpi1, Id2, Tgtp, H2-Ab1, Gbp4, Oasl2, Tapbp,
H2-M3, H2-DMb1, Cxcl10, H2-T23, Il2rg, Syk, Cfp, H2-D1, Cdkn1a,
Serping1, Gbp2, Fcgr1, Cxcl11, Cd47, Ifih1, H2-K1, H2-DMa, Tap1,
Ifi30, Fcer1g, Irf1, C4b, Tap2, Psme1, Ccl5, Coro1a, CD45, Psmb9,
Lyn, H2-Aa, Cd74, Irf8, Psme2, Tapbpl, Dbnl, C1qb, C1qc, Prkcd,
Cxcl9, Tgfb1, Rsad2, Clec4a2, Gbp6, Bcl2a1a, Cxcl14, Ly86, C1s,
Lilrb3, Irgm, Pnp, C3, B2m, Thy1, Irf7, Unc93b1, Cfb, C1qa, Serpina3g,
Smad3, Fcgr2b, H2-Eb1, Ccl6, Timp1, Lst1, Cebpa, C1r, Cd14,
Psmb8, Cd300d, C2
Clec7a, Pnp, Serping1, Fcgr1, C3, B2m, Thy1, Unc93b1, H2-K1, H2DMa, Fcer1g, Cfb, C1qa, C1qb, Smad3, C1qc, C4b, Fcgr2b, Tap2, H2M3, CD45, Lyn, C1r, Syk, C1s, Cfp
Clec7a, Serping1, Fcgr1, C3, Cxcl11, Fcer1g, Cfb, C1qa, Fn1, Lbp,
Cd44, C1qb, Pycard, C1qc, C4b, Fcgr2b, Cxcl9, Tgfb1, Ccl5, Cxcl10,
C1r, Ly86, Cd14, C1s, Cfp
Cdkn1a, Itgb2, Pnp, H2-DMa, Cd274, Sfpi1, Fcer1g, Lbp, Irf1, Smad3,
Prkcd, Fcgr2b, Tgfb1, Cd48, H2-M3, Coro1a, CD45, H2-Aa, Il2rg, Syk,
Cd74, Lilrb3
Pnp, Serping1, Fcgr1, C3, B2m, Irf7, H2-K1, H2-DMa, Fcer1g, C1qa,
C1qb, C1qc, C4b, Prkcd, Fcgr2b, Tap2, H2-M3, CD45, C1r, Lilrb3,
C1s, Cd74
Clec7a, Irgm, Serping1, Fcgr1, C3, Unc93b1, Ifih1, Cfb, C1qa, Lbp,
C1qb, C1qc, C4b, H2-M3, C1r, C1s, Cfp
Serping1, Fcgr1, C3, Irf7, H2-DMa, Fcer1g, C1qa, C1qb, C1qc, C4b,
Fcgr2b, Prkcd, CD45, C1r, C1s, Cd74, Lilrb3
Irf8, Pnp, H2-DMa, Sfpi1, Id2, Irf1, Timp1, Tgfb1, Cebpa, CD45, Lyn,
H2-Aa, Il2rg, Cd74, Lilrb3, Syk
Smad3, Itgb2, Pnp, Tgfb1, H2-DMa, H2-M3, Cd274, Cd48, Coro1a,
CD45, H2-Aa, Il2rg, Irf1, Syk, Cd74
GO:0002504
GO:0006956
GO:0006909
GO:0002474
Ag presentation
via MHC class II
Complement
activation
Phagocytosis
Ag presentation
via MHC class I
7.79 E-13
10
19
2.4%
0.1%
1.34e-09
10
35
2.4%
0.1%
H2-Eb1, Fcgr2b, Unc93b1, H2-DMa, H2-DMb1, Ifi30, Fcer1g, H2-Ab1,
H2-Aa, Cd74
C4b, C1qc, Serping1, C3, C1qa, Cfb, C1qb, C1r, Cfp, C1s
7.24e-07
1.03 E-08
9
8
46
20
2.2%
1.9%
0.1%
0.1%
Hck, Clec7a, Fcgr2b, Fcgr1, C3, Cd47, Sirpa, Fcer1g, Lbp
H2-D1, Tapbp, Fcgr1, B2m, H2-K1, Tapbpl, Fcer1g, H2-T23