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CURRICULUM VITAE
Majid Shahbazi PhD
Medical Cellular & Molecular Research Center
Talghani Children University hospital
Bolv. Janbazan, Zip cod- 4916668197
Gorgan, Iran
[email protected]
[email protected] [email protected]
Positions:
Since 2004 I have been working in Gorgan University of Medical Sciences as an assistant professor &
Director of Medical Cellular & Molecular Research Center.
2001-2003 Post-doctoral position on the Wellcome trust for cell matrix center on gene expression of
Cycline-Dependent Kinase Inhibitors (CDKIs) on chondrocytes in Dr Gillian Wallis and Dr Ray BootHandford labs, which is funded by National Institute of Health (NIH) Arthrit Research Council (ARC)
Training:
1998-2001: PhD in the field of immunology and genetics, under supervision of professor Ian V
Hutchinson
The Subject was: GROWTH FACTOR GENES Polymorphisms. (EGF, IGF-I, PDGF, bFGFand
VEGF) in control and diseases.
1997-1998: MSc in Immunology & immmunogetics.
1987-1990: MSc in medical parasitology from school of Public Health University of medical sciences
the subject was study of cross reactivity between hydatic cyst and Actinomycetes.
1983-1987: BSc from school of Public Health University of medical sciences.
1
Publication
1. Marzieh Attar, Saleh Shahbazi Azar, Majid Shahbazi. Interlukin-6 -174 promoter
polymorphism intensifies susceptibility to hepatitis B virus as a risk factor for
hepatocellular carcinoma in an Iranian population. Accepted 2016-02-13
2. Maryam Mansoori, Masoud Golalipour, Shahriar Alizadeh, Ataollah Jahangirerad, Seyed Reza
Khandozi, Habibollah Fakharai and Majid Shahbazi . Variations of the ABCB1 gene may
lead to an mRNA level increase: application to gastric cancer .Asian pacific journal of cancer
prevention .Accepted date: October 2015
3. Ayyoob Khosravi, Bita Javan, Mohammad Amin Tabatabaiefar, Hamid Ebadi, Davood Fathi,
Majid Shahbazi. Association of Interleukin-1 gene cluster polymorphisms and haplotypes
with multiple sclerosis in an Iranian population. Journal of Neuroimmunology. Accepted
date: 22 September 2015
4. Masoumeh Ghasemi, Elham Kashani, Azadeh Fayyaz, Marzieh Attar, Majid Shahbazi.
Interleukin-1 alpha variation is associated with the risk of developing preeclampsia.
European Journal of Obstetrics & Gynecology and Reproductive Biology . 193 (2015) 75–78
5. Hamidreza Iranpoor, Eskandar Omidinia, Venus Vatankhah, Vahid Gharanjik ,Majid Shahbazi.
Expression of Recombinant Human Insulin-like Growth Factor Type 1 (rhIGF-1) in
Escherichia coli. Avicenna Journal of Medical Biotechnology. Vol. 7, No. 3, July-September
2015
6. Touraj Farazmandfar, Mohammad Reza Haghshenas, Majid Shahbazi. Inhibition of HIV-1 by
a Lentiviral Vector with a Novel Tat-Inducible AU2c Expression System and a Specific
Tropism to the Target Cells. Human gene therapy, volume 26 number 00. doi:
10.1089/hum.2015.031
7. Mahakizadeh Simin; Jahanshahi Mehrdad; Haidari Kamran, Shahbazi Majid. Dopamine
Receptors Gene Expression in Male Rat Hippocampus after Administration of MDMA
(Ecstasy). Int. J. Morphol. 33(1):301-308, 2015.
8.
Arash Tahmasebifar, Yaghoub Yazdani, Pooria Gill, Majid Shahbazi. Nanoscopic Study of
Gold Nanorods Used for Efficient Delivery of Sirna in Cancer NanoTherapy. American
Journal of Advanced Drug Delivery. 2014
2
9.
Alireza Haghighi, Davood Fathi, Majid Shahbazi, Mohammad-Mahdy Motahari, Bethany
Friedman. Identification of a c.601 C>G mutation in the CCM1 gene in a kindred with
multiple skin, spinal and cerebral cavernous malformations. Journal of the Neurological
Sciences (2013)
10. Kollaee A, Ghaffarpor M, Pourmahmoudian H, Shahbazi M, Zamani M: Investigation of
CD24 and Its Expression in Iranian Relapsing-Remitting Multiple Sclerosis. Int J Neurosci.
2011 Dec;121(12):684-90
11. M. Zamani,
M. Mehri,
A. Kollaee,
P. Yenki,
M. Ghaffarpor, M.H. Harirchian
M. Shahbazi: Pharmacogenetic Study on the Effect of Rivastigmine on PS2 and APOE
Genes in Iranian Alzheimer. Dement Geriatr Cogn Disord Extra 2011; 1:180–189.
12. Shahbazi M, Roshandel D, Omidineya E, Rashidbaghan A: Interaction of HLA-DRB1*1501
allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to
multiple sclerosis. Clin Immunol. 2011; 139(3):277-81.
13. Shahbazi M, Ebadi H, Fathi D, Roshandel D, Mohamadhosseni M, Tahmasebi A, Shahbazi S,
Zamani M, Rashidbaghan A. HLA-DRB1*1501 intensifies the impact of IL-6 promoter
polymorphism on the susceptibility to multiple sclerosis in an Iranian population. Mult
Scler. 2010; 16(10):1173-7.
14. Shahbazi M, Roshandel D, Ebadi H, Fathi D, Zamani M, Boghaee M, Mohammadhoseeeni M,
Rshaidbaghan A, Bakhshandeh A, Shahbazi S.High frequency of the IL-2 -330 T/HLADRB1*1501 haplotype in patients with multiple sclerosis. Clin Immunol. 2010 ;137(1):134-8
15. Shahbazi M, Ebadi H, Fathi D, Roshandel D, Mahamadhoseeni M, Rashidbaghan A,
Mahammadi N, Mahammadi MR, Zamani M. CCR5-delta 32 allele is associated with the risk
of developing multiple sclerosis in the Iranian population. Cell Mol Neurobiol. 2009;
29(8):1205-9.
16. Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE,
Osborne JE, Lear JT, Smith AG, Hutchinson IV.Association between functional
polymorphism in EGF gene and malignant melanoma. Lancet. 2002; 359(9304): 397-401.
17. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, Harden
PN.Vascular endothelial growth factor gene polymorphisms are associated with acute
renal allograft rejection. J Am Soc Nephrol. 2002; 13(1): 260-4.
3
Presentation
18. Marzieh Attar, Maryam Mansoori, Majid Shahbazi. Evaluation of IL6 gene polymorphism
(position: -174) in Gastric cancers patients and healthy controls. The Second International
Gastrointestinal Cancer Congress. 14 - 16 October 2015, Tehran, Olympic Hotel
19. Ehsan Alaee, Behnaz Bazrafshan, seyed Ali Reza Azaminejad, Mahnaz Fooladi Nejad, Majid
Shahbazi. Evaluation of polymorphism UDGT1 (G71R) in the neonates with prlonged
icter. Third National Congress on Cellular and Molecular News in Non-Contagious Diseases
20. Samaneh Naeimipour, Marzieh Attar, Azam Bakhshandeh,Majid Shahbazi. Investigation of
frequency of interleukin-13 polymorphism (position +110) in multiple sclerosis patients
and control group. 10th International Iranian Ms congress. 2013, Isfahan, Iran
21. Azam Bakhshandeh, Marzieh attar, Samaneh naeimipour, Behnaz Bazrafshan, Parastoo kush, Majid
shahbazi. Evaluation of HLA-DQ gene polymorphism (DQ-A1 position: 0102) in MS
patients and healthy population. 10th International Iranian Ms congress. 2013, Isfahan, Iran
22. Behnaz Bazrafshan, Parastoo Kusha, Azam Bakhshandeh, Marzieh Attar, Samaneh Naeimipour,
Majid shahbazi. Evaluation of HLA-DQ gene polymorphism (DQ-B1 position: 0602) in MS
patients and healthy population. 10th International Iranian Ms congress. 2013, Isfahan, Iran
23. Samaneh Naeimipour, Reza Salehi Manzari, Aref Salehi, Seied Ali Sharifian, Marzieh Attar1,
Majid shahbazi. Investigation of InterLukin-13 ( +110 ( polymorphism in patients with
Coronary Artery Disease and healthy people. 2nd international Preventive Cardiology
congress. 16-18 oct 2013. Shiraz, Iran
24. Behnaz Bazrafshan, Reza Salehi Manzari, Samaneh Naeimi Pour, Seied Ali Sharifian, Aref
Salehi, Majid Shahbazi. Study of Functional Insulin-Like Growth Factor 1 gene
polymorphism in position -383 in people with Coronary Artery Disease (CAD) and healthy
control. 2nd international Preventive Cardiology congress. 16-18 oct 2013. Shiraz, Iran
25. Marzieh Attar, Majid Shahbazi. Association of IL6-174 promoter polymorphism with
hepatitis B infection in an Iranian population. 3nd Iranian genetic in medicine Congress. 1516 may 2013. Tehran, Iran. 2nd international Preventive Cardiology congress. 16-18 oct 2013.
Shiraz, Iran
26. S.ziyaie, Z.siyamarzgoie, M.baghbaniyan, M.shahbazi. Evaluation of genotyping in GM-CSF
(position - 1916) in multiple sclerosis patients & healthy controls Iranian population. 3nd
Iranian genetic in medicine Congress. 15-16 may 2013. Tehran, Iran
27. Reza Salehi Manzari, Aref Salehi, Hossein Ali Sharifian, Samaneh Naeimipour, Marzieh
Attar, Majid Shahbazi . Study of Functional Vascular Endothelial Growth Factor gene
polymorphism in position -2578 in people with CoronaryArtery Disease (CAD) and
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healthy control. 3nd Iranian genetic in medicine Congress. 15-16 may 2013. Tehran, Iran
28. Shahbazi M., Koochaki M., Sadeqi J., Fathi D. The susceptibility of multiple sclerosis is
influenced by IL-10 promoter polymorphisms and their combination with HLA-DRB1*15
alleles, among Iranian population. The 9th international MS congress of Iran. Tehran, Iran, 1-2
Nov 2012
29. Ziaee S., Siamarzgoie Z., Baghbanian M., Shahbazi M. Evaluation of genotyping in GM-CSF
in positions of GM-CSF (-1916) in multiple sclerosis patients & healthy controls Iranian
population. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012
30. Safari R , Sadeqi J, Koochaki M , Ebadi H ,Shahbazi M. Genetic variation of Nerve Growth
Factor )NGF( gene in MS patients and healthy Turkmen and non-Turkmen samples. The
9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012
31. Saleh Shahbazi, Davood Fathi, Majid Shahbazi. High frequency of the IL-2 −330 T/HLADRB1*1501 haplotype in patients with multiple sclerosis. The 9th international MS congress
of Iran. Tehran, Iran, 1-2 Nov 2012
32. Shahbazi M, Roshandel D , omidnyiab E , Rshaidbaghan A ,bakhshandeh A, Attar M.
Interaction of HLA-DRB1*1501 allele and TNF-alpha−308 G/A single nucleotide
polymorphism in the susceptibility to multiple sclerosis. The 9th international MS congress of
Iran. Tehran, Iran, 1-2 Nov 2012
33. Khosravi Ayyoob, Bita Javan, Mehrnaz Izadpanah, Majid Shahbazi. Association of IL-1β gene
polymorphisms with multiple sclerosis in Iranian population. The 9th international MS
congress of Iran. Tehran, Iran, 1-2 Nov 2012
34. Abdolmohammadi R, Ebadi H, Bakhshande A, Shahbazi M. Novel functional IGF-1 promoter
polymorphism (-383C>T) Association with the susceptibility to multiple sclerosis. The 9th
international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012
35. Ghasemi M. Shahbazi M. Evaluation of IL-1alpha gene polymorphism (position -889) in
pre-eclampsia and healthy pregnancy. 12th Iranian Genetic congress, 21-23 May 2012.
shahid beheshti university, Tehran, Iran (Persian)
36. Ghasemian N. Shahbazi M. Frequency determination of IFN_gamma gene
polymorphisms in HBs-Ag positive individuals and healthy controls. 12th Iranian Genetic
congress, 21-23 May 2012. shahid beheshti university, Tehran, Iran (Persian)
37. Javan B., Shahbazi M. polymorphisms of interleukin-1 Beta Genes in Patients with Chronic
Hepatitis B in Iran. 4th international Tehran Hepatitis Congress. Nov. 2011
38. Abdolmohammadi R. et al. Association of IGF-1 promoter polymorphism (-383C>T) with the
susceptibility to multiple sclerosis.2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June
2011
39. Mansoori M. et al. Association of TNF-α promoter polymorphism (-308G>A) with the outcome
of hepatitis B virus infection. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011
40. Bita Javan, et al. Polymorphism of interleukin-1 receptor antagonist gene in patients with
Chronic hepatitis B in Iran. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011
41. Tahmasebifar A. et al. HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism
5
on the susceptibility to multiple sclerosis in an Iranian population. 2nd Genetic in Medicine
congress, Tehran, Iran, 20-21 June 2011
42. Shahbaziazar S., et al. High frequency of the IL-2 −330 T/HLA-DRB1*1501 haplotype in
patients with multiple sclerosis. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June
2011
43. BITA Javan, Mohammad Reza Kalani, Ayyoob Khosravi, Maryam Mansoori, Reza
Abdolmohammadi, Majid shahbazi: Polymorphisms association of interleukin-1 alpha
genes in patients with chronic hepatitis B. The first international student congress on cell and
molecular medicine. Shiraz, Iran(17-19 february 2011)
44. Abdolmohammadi Reza, Ayyoob khosravi, Maryam Mansoori, Byta Javan, Saleh Shahbazi,
Majid Shahbazi. Association between CCR5 polymorphisms and susceptibility to HBV
infection. The first international student congress on cell and molecular medicine. Shiraz,
Iran(17-19 february 2011)
45. M. Shahbazi, H. Ebadi, M. Rahmat, M. Mohammad Hosseyni and N. Mohammadi: Role of
interleukin 4 in Iranian multiple sclerosis patients. (13th international of Immunology 2007)
46. M. Shahbazi, H. Ebadi, N. Mahammadi, D. Fathei, and M. Mahammadi: Association of
CCR5delta32 gene Deletion with multiple sclerosis in Iranian patients. (13th international of
Immunology 2007)
47. M. Shahbazi, H. Ebadi, D. Fathei, M. Mohammad Hosseyni and J. Lotfi: An assessment of the
association between IL-6 gene polymorphisms and Iranian patients with multiple sclerosis. (13th
international of Immunology 2007)
48. M. Shahbazi, H. Ebadi, a. Rashidbaghan, D. Fathei and, J. Lotfi : Genetic association studies of
tumour necrosis factor alpha-308 alleles in Iranian multiple sclerosis. (13th international of
Immunology 2007)
49. M. Shahbazi, H. Ebadi, D. Fathei, D. Roshandel, M. Mohammad Hosseyni and N. Mohammadi:
IL-10 promoter polymorphisms in Iranian patients with multiple sclerosis. (13th international
of Immunology 2007)
50. M. Shahbazi, M. Rahmat, A. Borghei, A. Bakhshandeh and J. Lotfi: Role of Heat shock protein
(HSP) 70-1 gene polymorphism in Iranian multiple sclerosis patients. (13th international of
Immunology 2007)
51. HM Ramsay, AA Fryer. PN Harden, M Shahbazi, V Pravica, IV Hutchinson: Platelet derived
growth factor gene polymorphisms are associated with non- Melanoma skin cancer risk in renal
transplant recipients. 6th annual scientific meeting of the international dermato-epidermiology
association. the Eden –IDEA congress the Netherlands 2001.
52.
M Shahbazi, V pravica, AA Fryer, HM Ramsay, IV Hutchinson and PN Harden: Insulin like
growth factor polymorphisms are associated with renal acute rejection risk. The British renal
association Annual meeting, Nottingham, UK, 2001
53. Majid Shahbazi, Anthony A Fryer, Vera Pravica, Helen M Ramsay, Paul N Harden and Ian V
Hutchinson: Functional Polymorphisms in VEGF are associated with increased risk of acute
6
rejection in renal transplant recipients. The 7the Basic sciences symposium of the
transplantation society August 2001 Switzerland, it will be published on transplant
Immunology on spring 2002.
54. M.Shahbazi, H.Fakhoury, A. A. Fryer, V. Pravica, R. C. Strange, P. E.Hutchinson, J.E.
Osborne, J. T. Lear, A. G. Smith and I.V. Hutchinson: Functional Polymorphism in the human
EGF gene malignant melanoma; 7th Annual Congress of British Society for Immunology,
Harrogate, UK; Immunology. Vol 101, Supplement 1 December 2000.
55. M. Shahbazi, A. A. Fryer, V. Pravica, H. M. Ramsay, P. N. Harden and I.V.Hutchinson:
Functional Polymorphisms in the human VEGF gene associated with renal acute rejection; 7th
Annual Congress of British Society for Immunology, Harrogate, UK; Immunology. Vol 101,
Supplement 1 December 2000.
56. M. Shahbazi, V. Pravica. M.R. Awad, I. Brogan, I. V. Hutchinson: Functional polymorphisms
in the growth factors (EGF, PDGF-BB, VEGF); The third joint international meeting of the
ICS and the ISICR Amsterdam the Netherlands; European cytokine Network Vol 11, Special
issue, November 2000.
57. Majid Shahbazi, Vera Pravica, Anthony A Fryer, Helen M Ramsay, Ian V Hutchinson and
Paul N Harden: Vascular endothelial growth factor gene Polymorphisms are associated with
acute rejection risk; The American society of nephrology 33rd Annual meeting 11-16
October 2000 Toronto, Canada.
58. M Shahbazi, H. Fakhoury, V. Pravica, and I. V. Hutchinson: A novel Polymorphism in the 5'
UTR of the human epidermal growth factor (EGF) gene associated with EGF production in
vitro. (Presentation BSI 1999).
Awards and Prizes:
Distinguished lecturer by Iranian Ministry of Health & Medical Education (1994).
Ongoing Research:
1- Gene profiling Multiple sclerosis (MS) patients and Turkmen and non-Turkmen healthy individuals.
2- Cloning and expression of human interleukin (IL-11) and analyses of it bioactivity in in vitro
3- Studying the changes in apoptosis induction of Adriamycin by IL-11 and changes in expression of
genes and proteins of p53, Bcl-2 and Caspase 3 in K562 and T47D human cancer cell lines.
4- Cloning and expression of human interleukin 2 gene in E.coli for production recombinant protein.
7
Further I have found and submitted following novel gene polymorphisms in the gene bank:
DEFINITION Homo sapiens insulin-like growth factor gene, promoter region.
ACCESSION AF417592
VERSION AF417592.1 GI:16033735
KEYWORDS .
SOURCE
human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 282)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Human insulin-like growth factor (IGF-I) gene, promoter region
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 282)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research
Group, School of Biological Sciences, University of
Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UK
FEATURES
Location/Qualifiers
source
1..282
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23"
/cell_type="peripheral blood mononuclear cells"
/tissue_type="blood"
promoter
<1..>282
/note="insulin-like growth factor; IGF-I"
variation
96
/note="polymorphism"
/replace="t"
BASE COUNT
70 a 73 c 54 g 85 t
ORIGIN
1 ctcatcgcag gagaaaaagt atgagacagt gccctaaagg gaccaatcca
51 atgctgcctg cccctccata ggttctagga aatgagatca cacccctcac
101 ttggcaactg ggacaagggg tcacccgagt gctgtcttcc aatctacttt
151 accccagtca cttcagggtt aaaattgtag agtttgctgg agagggtctt
201 atcgtccttt ctttcttttt ttgttttaaa taatgcattt gctctagaat
251 ctaaaattgc tctcccatcc cccatattcc tt
8
DEFINITION Homo sapiens insulin-like growth factor gene, promoter region.
ACCESSION AF417591
VERSION AF417591.1 GI:16033733
KEYWORDS .
SOURCE
human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 307)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Human insulin-like growth factor (IGF-I) gene, promoter region
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 307)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research
Group, School of Biological Sciences, University of
Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UK
FEATURES
Location/Qualifiers
source
1..307
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q23"
/cell_type="peripheral blood mononuclear cells"
/tissue_type="blood"
promoter
<1..>307
/note="insulin-like growth factor; IGF-I"
variation
271
/note="polymorphism"
/replace="c"
BASE COUNT 110 a 66 c 54 g 77 t
ORIGIN
1 aatgttgctg aacatagtgc accattgaca caacataatt ccagatttct
51 aactttgatt tctgaaaggt aaacattgct acaatgtatt aaccacacag
101 aagactcaaa caaacccaac ccccttccaa acaaagcagg tttgtttgtt
151 ttttgttagg gcacccactt ctacaaacaa atttctggcc ccaggataac
201 acaaagagcc agagtaggat ttcaagcaga actgtgtttt cagttgatgt
251 gtcagtcccc tgagagccat gtggaaaaaa aaaaaaagaa aaaattcaag
301 gtccagg
9
DEFINITION Homo sapiens platelet-derived growth factor A chain (PDGFA) gene, exon 1 and partial
sequence.
ACCESSION AF417590
VERSION AF417590.1 GI:16033732
KEYWORDS .
SOURCE
human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria;
Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 392)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Human platelet-derived growth factor A-chain (PDGF) gene,
5' end region
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 392)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research
Group, School of Biological Sciences, University of
Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UK
FEATURES
Location/Qualifiers
source
1..392
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p22-p21"
/cell_type="peripheral blood mononuclear cells"
/tissue_type="blood"
5'UTR
<1..>392
/gene="PDGFA"
mRNA
<1..>392
/gene="PDGFA"
/product="platelet-derived growth factor A chain"
gene
<1..>392
/gene="PDGFA"
exon
<1..>392
/gene="PDGFA"
/number=1
variation
327
/gene="PDGFA"
/note="polymorphism"
/replace="c"
BASE COUNT
29 a
142 c 182 g
39 t
10
ORIGIN
1 ctactcctcc tcctcctctc ccggcggcgg ctgcggcgga ggcgccgact
51 cggccttgcg cccgccctca ggcccgcgcg ggcggcgcag cgaggccccg
101 ggcggcgggt ggtggctgcc aggcggctcg gccgcgggcg ctgcccggcc
151 ccggcgagcg gagggcggag cgcggcgccg gagccgaggg cgcgccgcgg
201 agggggtgct gggccgcgct gtgcccggcc gggcggcggc tgcaagagga
251 ggccggaggc gagcgcgggg ccggcggtgg gcgcgcaggg cggctcgcag
301 ctcgcagccg gggccgggcc aggcgttcag gcaggtgatc ggtgtggcgg
351 cggcggcggc ggcggcccca gactccctcc ggagttcttc tt
DEFINITION Homo sapiens basic fibroblast growth factor gene, partial sequence.
ACCESSION AF239155
VERSION AF239155.1 GI:8308033
KEYWORDS .
SOURCE
human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 250)
AUTHORS Shahbazi,M. and Hutchinson,I.V.
TITLE Direct Submission
JOURNAL Submitted (24-FEB-2000) Cell, Development & Immunology,
School of Biological Sciences, Univesity of Manchester,
3.239 Stopford Bldg., Oxford Road, Manchester M13 9Pt, UK
FEATURES
Location/Qualifiers
source
1..250
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q25-q27"
/cell_type="mononculear"
/tissue_type="blood"
promoter
<1..11
mRNA
12..>250
/product="basic fibroblast growth factor"
5'UTR
12..>250
exon
12..>250
/number=1
variation
91
/replace="c"
variation
233
/replace="t"
11
BASE COUNT
43 a 71 c 107 g 29 t
ORIGIN
1 aactcagagg ccggccccag aaaacccgag cgagtagggg gcggcgcgca
51 ggagggagga gaactggggg cgcgggaggc tggtgggtgt cgggggtgga
101 gatgtagaag atgtgacgcc gcggcccggc gggtgccaga ttagcggacg
151 gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt gggaggcggc
201 tctccccagg cggcgtccgc ggagacaccc atctgtgaac cccaggtccc
DEFINITION Homo sapiens egf gene promoter and 5'UTR.
ACCESSION AJ131611
VERSION AJ131611.1 GI:7378722
KEYWORDS egf gene; epidermal growth factor.
SOURCE
human.
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 242)
AUTHORS Shahbazi,M., Fakhoury,H., Pravica,V. and Hutchinson,I.V.
TITLE A novel polymorphism in the human epidermal growth factor
EGF) 5'untranslated region
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 242)
AUTHORS Fakhoury,H.
TITLE Direct Submission
JOURNAL Submitted (22-DEC-1998) Fakhoury H., Immunology Research
Group, University of Manchester, Stopford Building, Oxford
Road, Manchester M13 9PT, UNITED KINGDOM
FEATURES
Location/Qualifiers
source
1..242
/organism="Homo sapiens"
/db_xref="taxon:9606"
promoter
<1..78
/gene="egf"
/standard_name="epidermal growth factor"
gene
1..242
/gene="egf"
5'UTR
79..242
/gene="egf"
/standard_name="epidermal growth factor"
variation
139
/gene="egf"
/replace="g"
12
BASE COUNT
64 a 54 c 52 g 72 t
ORIGIN
1 tgtcactaaa ggaaaggagg tggagcctga agagctttaa aaagcaaagc
51 tgagtcattc cacttttcaa aaagagaaac tgttgggaga ggaatcgtat
101 ctccatattt cttctttcag ccccaatcca agggttgtag ctggaacttt
151 ccatcagttc ttcctttctt tttcctctct aagcctttgc cttgctctgt
201 cacagtgaag tcagccagag cagggctgtt aaactctgtg aa
13