Download mmc1-2 - Candida Genome Database

Supplementary Material
Candida albicans exhibits enhanced alkaline and temperature
induction of Efg1-regulated transcripts relative to C. dubliniensis
Nicole Caplice and Gary P. Moran
Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, University of
Dublin, Trinity College Dublin, Dublin 2, Republic of Ireland
Contents:
Table S1. Genes upregulated 2-fold or more in C. albicans and C. dubliniensis in response to alkaline pH.
Table S2 Position and sequence of the Rim101-like binding site in C. dubliniensis.
Table S3. Genes repressed 2-fold or more in C. albicans and C. dubliniensis in response to alkaline pH
Table S4. Genes induced >2-fold in C. albicans and C. dubliniensis in response to a shift to 37˚C
Table S5. Genes down-regulated >2-fold in C. albicans and C. dubliniensis in response to a shift to 37˚C.
Table S6. Genes identified as induced > 2-fold in C. dubliniensis only in response to a shift to 37˚C
Table S7. Genes induced > 2-fold following nutrient depletion in C. dubliniensis
Table S8. Genes repressed > 2-fold following nutrient depletion in C. dubliniensis
Table S1. Genes upregulated 2-fold or more in both C. albicans and C. dubliniensis in response
to alkaline pH
Gene Class
Cell surface
Amino acid metabolism
Ion transport
Ribosome biogenesis
Cd36
Number
orf19
Number
Cd36_64210
Cd36_53830
Cd36_64370
Cd36_18190
Cd36_42920
Cd36_44230
Cd36_43400
Cd36_60800
Cd36_81470
Cd36_04870
Cd36_15310
Cd36_52570
Cd36_53250
Cd36_51530
Cd36_07920
Cd36_50700
Cd36_45400
Cd36_00320
Cd36_32920
Cd36_70310
Cd36_13190
Cd36_01620
Cd36_41830
Cd36_22250
Cd36_21110
Cd36_02820
Cd36_29390
Cd36_00190
Cd36_85070
Cd36_18480
Cd36_62220
Cd36_23540
Cd36_13080
Cd36_71620
Cd36_85230
Cd36_82430
Cd36_02890
Cd36_87080
Cd36_84630
Cd36_70890
Cd36_33780
Cd36_06050
Cd36_03380
Cd36_16470
Cd36_24720
Cd36_01510
Cd36_41260
orf19.5741
orf19.3895
orf19.5760
orf19.876
orf19.2685
orf19.3829
orf19.1327
orf19.3642
orf19.1690
orf19.4060
orf19.2098
orf19.4304
orf19.6659
orf19.3195
orf19.386
orf19.568
orf19.1264
orf19.6070
orf19.6139
orf19.7112
orf19.7231
orf19.4546
orf19.4599
orf19.2179
orf19.2232
orf19.2994
orf19.493
orf19.6085
orf19.5982
orf19.840
orf19.3504
orf19.1601
orf19.7217
orf19.6541
orf19.6002
orf19.236
orf19.3002
orf19.6785
orf19.5927
orf19.7018
orf19.6375
orf19.6265
orf19.6265
orf19.1470
orf19.5341
orf19.5341
orf19.4660
Common
Name
ALS1
CHT2
IHD1
PGA33
PGA54
PHR1
RBT1
SUN41
TOS1
ARO4
ARO8
GAP1
GAP6
HIP1
SAM4
SPE2
CFL2
ENA22
FRE7
FRP2
FTR2
HOL4
PHO89
SIT1
RPL11
RPL13
RPL15A
RPL16A
RPL18
RPL21A
RPL23A
RPL3
RPL4B
RPL5
RPL8B
RPL9B
RPS1
RPS12
RPS15
RPS18
RPS20
RPS22A
RPS22A
RPS26A
RPS4A
RPS4A
RPS6A
Annotation
Adhesin; ALS family of cell-surface glycoproteins
Putative GPI-anchored chitinase
Putative GPI-anchored protein of unknown function
Putative GPI-anchored protein of unknown function
Putative GPI-anchored protein; hyphal induced
Glycosidase of hyphal cell surface
Putative cell wall protein with similarity to Hwp1p
Putative cell wall glycosidase involved in biofilm formation
Protein described as similar to alpha agglutinin anchor
3-Deoxy-D-arabinoheptulosonate-7-phosphate synthase
Aromatic transaminase of aromatic alcohol biosynthesis
General amino acid permease
Putative general amino acid permease
Similar to amino acid permeases
S-adenosylmethionine-homocysteine methyltransferase
Putative S-adenosylmethionine decarboxylase
Iron utilization protein
Described as sodium transporter
Protein similar to ferric reductase Fre10p
Protein described as ferric reductase
High-affinity iron permease
Protein described as an ion transporter
Putative phosphate permease
Transporter of ferrichrome siderophores,
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Predicted ribosomal protein
Transcription
Miscellaneous
Uncharacterised
Cd36_81410
Cd36_20060
Cd36_85350
Cd36_33150
Cd36_04890
Cd36_52000
Cd36_41920
Cd36_13310
orf19.1700
orf19.6873
orf19.6975
orf19.2623
orf19.4056
orf19.4225
orf19.4590
orf19.7247
RPS7A
RPS8A
YST1
ECM22
GAT2
LEU3
RFX2
RIM101
Cd36_84480
Cd36_05880
orf19.5908
orf19.1822
TEC1
UME6
Cd36_81390
orf19.1702
ARF3
Cd36_72240
Cd36_34550
Cd36_51080
Cd36_60850
orf19.6459
orf19.7312
orf19.1944
orf19.85
DPP3
ERG13
GPR1
GPX2
Cd36_00690
Cd36_03820
Cd36_54530
Cd36_07220
orf19.6028
orf19.4482
orf19.3981
orf19.1232
HGC1
IFI3
MAL31
VRG4
Predicted ribosomal protein
Predicted ribosomal protein
Ribosome-associated protein
Predicted zinc-finger protein of unknown function
Putative DNA-binding transcription factor
Predicted zinc-finger protein of unknown function
Transcriptional repressor; regulator of filamentation
Transcription factor involved in alkaline pH response
TEA/ATTS transcription factor involved in regulation of
hypha-specific genes
Transcription factor required for hyphal elongation
Similar to yeast GTPase of the Ras superfamily involved in
development of polarity
Protein similar to S. cerevisiae pyrophosphate
phosphatase Dpp1p
Protein similar to S. cerevisiae Erg13p
Putative G-protein-coupled receptor of plasma membrane
Similar to glutathione peroxidase
Hypha-specific G1 cyclin-related protein involved in
regulation of hyphal morphogenesis
Predicted ORF in Assemblies 19, 20 and 21
Putative high-affinity maltose transporter
GDP-mannose transporter
Cd36_81400, Cd36_52910, Cd36_40980,Cd36_04210, Cd36_62530,Cd36_06760, Cd36_27170,
Cd36_53200, Cd36_72740, Cd36_62990, Cd36_12430, Cd36_61130, Cd36_44910, Cd36_63970,
Cd36_13160
Table S2. Position and sequence of the Rim101-like binding site in the promoters of pH regulated
genes in C. dubliniensis identified with MEME (http://meme.sdsc.edu) Strand refers to whether the
motif is present in the sense (-) or antisense (-) strand of double stranded DNA. Numbers refer to
location of the motif where +1 represents the first A of the respective ATG codon. The p-value
gives the probability of a random string (generated from the background letter frequencies) having
the same match score or higher.
NAME
Cd36_00320
Common Name
ENA22
Cd36_00320
ENA22
Cd36_00320
ENA22
Cd36_70310
Cd36_70310
Cd36_70310
Cd36_41830
STRAND
+
START
-551
P-VALUE
1.85E-05
5'
GAAATTGCAA
SITE
CCAAGAAA
3'
AAATAAAAGA
+
-1186
1.85E-05
CCAATTCAAA
CCAAGAAA
AAAAAAATAG
-
-1548
1.85E-05
CATAATTTCA
CAAAGAAA
AACGTGACTT
FRP2
-
-387
1.85E-05
CTGCTTGGAA
CCAAGAAA
AATACAAGAC
FRP2
-
-331
5.83E-05
AAGTGTAATA
CAAAGAAA
AAAGAATGCT
FRP2
-
-834
5.83E-05
ATTATCACAA
CAAAGAAA
AACCTTTGGA
PHO89
+
-595
1.85E-05
ATTTCAATTG
CCAAGAAA
TGCTGAATTT
Cd36_41830
PHO89
-
-1119
1.85E-05
GAAATTGCAA
CCAAGAAA
AAAAAAAAAA
Cd36_41830
PHO89
-
-1082
5.83E-05
CCTTCTATAA
CAAAGAAA
ACACCGAAAT
Cd36_41830
PHO89
+
-1765
5.83E-05
AATAAAAGCG
CAAAGAAA
TAATGAATAA
Cd36_45400
CFL2
-
-41
1.85E-05
TGAAAACTGT
CCAAGAAA
ATCAACAAGT
Cd36_45400
CFL2
+
-848
1.85E-05
CTAGTATAAG
CCAAGAAA
AGTTATGTAG
Cd36_45400
CFL2
+
-968
5.83E-05
AGAAAACACT
CAAAGAAA
CGAGGAATCA
Cd36_85750
SKN1
+
-268
1.85E-05
TATATGTAAC
CCAAGAAA
TTCTTAATAA
Cd36_85750
SKN1
+
-465
1.85E-05
TTAAGAATTA
CCAAGAAA
TTTGGCCCCA
Cd36_85750
SKN1
-
-1764
7.68E-05
AGAGTTGCTG
CCAACAAA
CACTCTACAA
Cd36_04500
IFE1
+
-291
1.85E-05
CATGATAATT
CCAAGAAA
TATTGTAGAC
Cd36_04500
IFE1
+
-239
5.83E-05
AACACATATT
CAAAGAAA
CCACAAAATA
Cd36_04500
IFE1
-
-363
5.83E-05
CTCAATCCAC
CAAAGAAA
AATAATTGTC
Cd36_44230
PHR1
+
-557
1.85E-05
GGAAATAAAA
CCAAGAAA
ATTTATTCAA
Cd36_44230
PHR1
+
-869
1.85E-05
AGAAAGAATT
CCAAGAAA
AATACTCATT
Cd36_44230
PHR1
-
-326
5.83E-05
GTGAATTTCT
CAAAGAAA
GGCGACAGTA
Cd36_32920
FRE7
+
-16
5.83E-05
GCCGTACCTA
CAAAGAAA
ACACAAGA
Cd36_32920
FRE7
+
-527
7.68E-05
TGATTTCCCA
CCAACAAA
GATTCGTTGC
Table S3. Genes repressed 2-fold or more in both C. albicans and C. dubliniensis in response to
alkaline pH
Gene Class
General Metabolism
Oxidoreductases
Stress response
Transport
Amino acid
metabolism/transport
Signalling/kinases
Hexose transport
Transcription factor
Cell surface
Cell wall biosynthesis
Cd36
Number
Cd36_01580
Cd36_10950
Cd36_32740
Cd36_33110
Cd36_62170
Cd36_09130
Cd36_12650
Cd36_50900
Cd36_34630
orf19
Number
orf19.4551
orf19.1153
orf19.734
orf19.6116
orf19.3507
orf19.4833
orf19.5005
orf19.4135
orf19.7324
Common
Name
CTN1
GAD1
GLK1
GLK4
MCR1
MLS1
OSM2
PRC2
THI13
Cd36_07850
Cd36_27000
Cd36_42290
Cd36_17750
Cd36_30420
Cd36_30670
Cd36_23350
Cd36_31940
Cd36_33850
Cd36_01850
Cd36_12490
Cd36_18140
Cd36_07580
Cd36_08730
Cd36_51400
Cd36_43830
Cd36_64450
Cd36_17380
Cd36_32400
orf19.5113
orf19.2608
orf19.2762
orf19.5805
orf19.638
orf19.5288
orf19.4082
orf19.720
orf19.6387
orf19.4526
orf19.4980
orf19.882
orf19.5079
orf19.4784
orf19.1979
orf19.5307
orf19.5770
orf19.1585
orf19.1847
ADH2
ADH5
AHP1
DLD1
FDH1
IFE2
DDR48
GST3
HSP104
HSP30
HSP70
HSP78
CDR4
CRP1
GIT1
JEN2
OPT8
ZRT2
ARO10
Cd36_16150
Cd36_85550
Cd36_06130
Cd36_10070
Cd36_18460
Cd36_12480
Cd36_00160
Cd36_41060
Cd36_80200
Cd36_28610
Cd36_28770
Cd36_86810
Cd36_32610
Cd36_29780
Cd36_29770
Cd36_52400
Cd36_12220
orf19.1996
orf19.6993
orf19.6257
orf19.2344
orf19.842
orf19.4979
orf19.6091
orf19.4682
orf19.5447
orf19.4384
orf19.4384
orf19.6817
orf19.2356
orf19.535
orf19.532
orf19.4279
orf19.4943
CHA1
GAP2
GLT1
ASR1
ASR3
KNS1
RIM8
HGT17
HGT19
HXT5
HXT5
FCR1
CRZ2
RBR1
RBR2
MNN1
PSA2
Annotation
Predicted carnitine acetyl transferase
Protein described as glutamate decarboxylase
Putative glucokinase
Putative glucokinase
Protein described as NADH-cytochrome-b5 reductase
Malate synthase; enzyme of the glyoxylate cycle
Protein described as mitochondrial fumarate reductase
Protein described as a carboxypeptidase
Similar to S. cerevisiae Thi13p, synthesis of the thiamine
precursor hydroxymethylpyrimidine
Putative alcohol dehydrogenase
Putative alcohol dehydrogenase
Putative alkyl hydroperoxide reductase
Putative D-lactate dehydrogenase
Putative formate dehydrogenase
Protein described as an alcohol dehydrogenase
Immunogenic stress-associated protein
Putative glutathione S-transferase
Functional homolog of S. cerevisiae Hsp104p
Protein described as similar to heat shock protein
Putative chaperone of Hsp70 family
Protein described as a heat-shock protein
Putative transporter of ATP-binding cassette (ABC) superfamily
Copper transporter of the plasma membrane; P1-type ATPase
Putative glycerophosphoinositol permease
Protein described as carboxylic acid transporter
Possible oligopeptide transporter
Protein described as predicted zinc transporter
Aromatic decarboxylase of the Ehrlich fusel oil pathway of
aromatic alcohol biosynthesis
Protein similar to serine/threonine dehydratases
Protein similar to amino acid permeases
Alkaline downregulated
Protein described as similar to heat shock proteins
Gene regulated by cAMP and by osmotic stress
Similar to S. cerevisiae Kns1p, which is a protein kinase
Protein involved in the pH response pathway
Putative glucose transporter
Putative glucose/myo-inositol transporter
Protein described as a sugar transporter
Protein described as a sugar transporter
Putative zinc cluster transcription factor
Putative transcription factor; zinc finger
Glycosylphosphatidylinositol (GPI)-anchored cell wall protein
Cell wall protein; expression is repressed by Rim101p
Putative alpha-1,3-mannosyltransferase
GDP-mannose pyrophosphorylase
Miscellaneous
Uncharacterised
Cd36_09690
Cd36_43220
Cd36_80440
Cd36_12150
Cd36_72040
Cd36_18330
orf19.4899
orf19.3369
orf19.5417
orf19.4934
orf19.6489
orf19.856
GCA1
MOH1
DOT5
OP4
FMP45
IFK2
Predicted plasma membrane-associated glucoamylase
Protein similar to S. cerevisiae Moh1p
Alkaline downregulated
Ala- Leu- and Ser-rich protein
Protein induced during the mating process
Protein not essential for viability
Cd36_00340, Cd36_01140, Cd36_01500, Cd36_04190, Cd36_08690, Cd36_08720, Cd36_09200,
Cd36_09560, Cd36_09680, Cd36_09800, Cd36_10510, Cd36_10570, Cd36_10980, Cd36_12250,
Cd36_15160, Cd36_15700, Cd36_16390, Cd36_16860, Cd36_17180, Cd36_18660, Cd36_20100,
Cd36_21350, Cd36_21680, Cd36_21910, Cd36_22040, Cd36_22390, Cd36_22420, Cd36_23910,
Cd36_27950, Cd36_28920, Cd36_31150, Cd36_33100, Cd36_34410, Cd36_40480, Cd36_42090,
Cd36_42230, Cd36_42490, Cd36_42520, Cd36_42860, Cd36_43140, Cd36_44390, Cd36_46100,
Cd36_50140, Cd36_50170, Cd36_50930, Cd36_51940, Cd36_63190, Cd36_65120, Cd36_70560,
Cd36_72320, Cd36_72690, Cd36_81350, Cd36_83680, Cd36_83750, Cd36_87190, Cd36_87250
Table S4. Genes induced >2-fold in both C. albicans and C. dubliniensis in response to a shift to
37˚C
Gene class
Amino acid metabolism
Ribosomal Proteins/biogenesis
Cd36
Number
Cd36_33360
Cd36_16830
Cd36_04870
orf19
Number
orf19.1986
orf19.1517
orf19.4060
Cd36_23240
Cd36_33930
Cd36_17220
Cd36_82300
Cd36_50440
Cd36_07920
Cd36_17680
Cd36_11260
orf19.198
orf19.6402
orf19.1559
orf19.1613
orf19.946
orf19.386
orf19.5838
orf19.5263
Cd36_21250
orf19.2250
Cd36_11440
Cd36_46560
Cd36_42850
Cd36_05310
Cd36_22190
Cd36_31630
Cd36_02890
Cd36_19730
Cd36_62430
orf19.5243
orf19.3099
orf19.2694
orf19.2489
orf19.2185
orf19.3867
orf19.3002
orf19.3553
orf19.3465
Cd36_21110
Cd36_82090
Cd36_02820
Cd36_19200
Cd36_85070
Cd36_41520
Cd36_18480
Cd36_44530
Cd36_23540
Cd36_10350
Cd36_85230
Cd36_82430
Cd36_84640
orf19.2232
orf19.1635
orf19.2994
orf19.4490
orf19.5982
orf19.4632
orf19.840
orf19.3789
orf19.1601
orf19.2311
orf19.6002
orf19.236
orf19.5928
Cd36_87080
Cd36_84630
Cd36_01360
Cd36_33780
Cd36_06050
Cd36_06170
Cd36_80110
Cd36_16470
Cd36_46640
Cd36_52860
Cd36_81410
orf19.6785
orf19.5927
orf19.3334
orf19.6375
orf19.6265
orf19.6253
orf19.5466
orf19.1470
orf19.3087
orf19.4336
orf19.1700
Common Annotation
name
ARO2
Chorismate synthase
ARO3
2-dehydro-3-deoxy-phosphoheptonate aldolase
ARO4
3-deoxy-D-arabino-heptulosonate 7-phosphate
(DAHP) synthase
ASN1
asparagine synthetase
CYS3
cystathione gamma lyase
HOM2
Aspartate-semialdehyde dehydrogenase
ILV2
acetolactate synthase
MET14
adenylylsulfate kinase
SAM4
AdoMet-homocysteine methyltransferase
SER2
Putative phosphoserine phosphatase
SER3
3-phosphoglycerate dehydrogenase, serine
biosynthesis
SPE3
spermidine synthase, putrescine
aminopropyltransferase
TRP3
anthranilate synthase, tryptophan biosynthesis
TRP4
anthranilate phosphoribosyltransferase
TYS1
tyrosyl-tRNA synthetase
KAP123
Ran binding protein, homolog of importin-beta
NSA1
Nop seven associated, ribosome biogenesis
RLP7
ribosomal-like proteins
RP1
ribosomal protein 10
RPF2
ribosome large subunit assembly
RPL10A
ribosomal protein L1A that forms part of the 60S
ribosomal subunit
RPL11
ribosomal protein L11A
RPL12
large subunit ribosomal protein L12.e
RPL13
ribosomal protein
RPL17B
ribosomal protein L17B
RPL18
ribosomal protein L18A (rp28A)
RPL20B
ribosomal protein L20
RPL21A
ribosomal protein L21
RPL24A
ribosomal protein L24A (rp29) (YL21) (L30A)
RPL3
60S large subunit ribosomal protein L3.e
RPL8A
ribosomal protein L8B
RPL8B
ribosomal protein L8B (L4B) (rp6) (YL5)
RPL9B
ribosomal protein L9B
RPP2B
acidic ribosomal protein P2B, ribosomal protein
P2B (YP2beta) (L45)
RPS12
acidic ribosomal protein S12
RPS15
ribosomal protein S15 (S21) (rp52) (RIG protein)
RPS2
ribosomal protein
RPS20
ribosomal protein S20
RPS22
ribosomal protein
RPS23
ribosomal protein S23A
RPS24
ribosomal protein S24
RPS26A
40S small subunit ribosomal protein S26A
RPS31
small subunit ribosomal protein
RPS5
ribosomal small subunit protein
RPS7A
ribosomal protein S7A
Miscellaneous
Mitochondrial
RNA metabolism
General metabolism
Translation
Lipid metabolism
Cell cycle
DNA replication
ER/Golgi/secretion
Cd36_20060
Cd36_17060
Cd36_00850
Cd36_29520
Cd36_11250
Cd36_87210
Cd36_64230
Cd36_12110
Cd36_03150
orf19.6873
orf19.1578
orf19.6014
orf19.508
orf19.5265
orf19.6766
orf19.5746
orf19.4931
orf19.3034
RPS8
RRP5
RRS1
QDR1
KIP4
NOP13
ALA1
CysRS
RLI1
Cd36_02510
Cd36_73140
orf19.2960
orf19.6705
FRS2
YEL1
Cd36_62600
Cd36_73450
Cd36_51460
orf19.3481
orf19.7203
orf19.585
MRH4
MRP7
MRPL17
Cd36_18600
Cd36_11130
Cd36_33020
Cd36_19250
orf19.828
orf19.5279
orf19.6129
orf19.150
MRPL24
MRPL51
MRPL8
TIM17
Cd36_06740
Cd36_70880
Cd36_63520
Cd36_85130
Cd36_07810
Cd36_73370
Cd36_06990
Cd36_63370
Cd36_04140
Cd36_00170
Cd36_35040
Cd36_80300
Cd36_30110
Cd36_07910
Cd36_08950
Cd36_53520
Cd36_00970
Cd36_40750
Cd36_29510
Cd36_50780
Cd36_51990
Cd36_61720
Cd36_32660
Cd36_71100
orf19.4447
orf19.7019
orf19.5704
orf19.5991
orf19.5106
orf19.5507
orf19.2795
orf19.5550
orf19.5198
orf19.6090
orf19.7569
orf19.5436
orf19.6317
orf19.385
orf19.4813
orf19.1115
orf19.3291
orf19.4172
orf19.506
orf19.4152
orf19.4223
orf19.3423
orf19.1815
orf19.6906
YMC1
YML6
Cd36_34550
Cd36_80290
Cd36_35370
Cd36_20530
orf19.7312
orf19.5437
orf19.7634
orf19.4105
ERG13
RHR2
MCD1
CSM3
Cd36_27030
Cd36_20640
Cd36_41210
orf19.2611
orf19.5487
orf19.4668
MCM6
CDC46
SCW11
DBP10
DIP2
ENP1
LHP1
MRT4
NOP4
NSR1
SIK1
UTP8
ADE6
GCV2
GUA1
GUK1
HMT1
PHO13
YDJ1
EFT3
EIF2
TIF3
TIF6
ASC1
ribosomal protein S8E
processing of pre-rRNA to 18S and 5.8S rRNA
regulator of ribosome synthesis
multidrug resistance transporter
kinesin heavy chain homolog
Nucleolar Protein 13
alanyl-tRNA synthetase
cysteinyl-tRNA synthetase
putative member of ATP-binding cassette (ABC)
superfamily
Phenylalanine tRNA synthetase
putative guanyl nucleotide exchange factor with
Sec7 domain
DEAD-bix ATP-dependent RNA helicase
mitochondrial large ribosomal subunit
mitochondrial ribosomal protein of the large
subunit
mitochondrial ribosomal protein
conserved hypothetical protein
mitochondrial 60s ribosomal subunit
mitochondrial inner membrane import
translocase subunit
mitochondrial carrier protein
mitochondrial ribosomal protein
hypothetical protein
ATP dependent RNA helicase
beta transducin
rRNA processing
RNA binding protein similar to human La antigen
required for mRNA decay
nucleolar protein
nuclear localization sequence binding protein
nucleolar protein involved in pre- rRNA processing
snoRNA binding protein
5'-phosphoribosylformyl glycinamidine synthetase
glycine decarboxylase complex P subunit
GMP synthase
guanylate kinase
hnRNP methyltransferase
Putatuve alkaline phosphatase
dnaJ homolog and heat shock protein
translation elongation factor
translation initiation factor
translation initiation factor eIF4B
translation initiation factor 6 (eIF6)
WD repeat protein, interacts with translational
machinery
3-hydroxy-3-methylglutaryl coenzyme A synthase
DL-glycerol-3-phosphatase
Mitotic Chromosome Determinant
conserved hypothetical protein required for
chromosome segregation
involved in replication
part of ARS replication initiation complex
glucan 1,3 beta-glucosidase-like protein
Oxidative stress
Cell wall components
Sugar metabolism
Transcription factors/chromatin
Unknown process and function
Cd36_11970
Cd36_61280
Cd36_15900
Cd36_60850
Cd36_64370
orf19.6343
orf19.124
orf19.2028
orf19.85
orf19.5760
FEN1
CIC1
MXR1
GPX1
IHD1
Cd36_85580
Cd36_70090
Cd36_41940
Cd36_30150
orf19.6996
orf19.7062
orf19.4587
orf19.6314
MNT44
RPA135
HGH1
RPB8
Cd36_19820
Cd36_00570
orf19.3564
orf19.6041
RPC40
RPO41
involved in synthesis of 1,3-beta-glucan
protease substrate recruitment factor
Putative methionine sulfoxide reductase
glutathione peroxidase
Induced in Hyphal Development, membrane
protein
alpha-1,3- mannosyltransferase
DNA-directed RNA polymerase I
putative DNA-binding protein of the HMG family
16-kDa RNA polymerase subunit (common to
polymerases I, II and III)
RNA polymerase III (C) subunit
mitochondrial DNA-directed RNA polymerase
Cd36_86710, Cd36_41240, Cd36_20190, Cd36_19020, Cd36_51250, Cd36_52430,
Cd36_35220, Cd36_52320, Cd36_23010, Cd36_18500
Table S5. Genes down-regulated >2-fold in both C. albicans and C. dubliniensis in response to a
shift to 37˚C.
Gene class(es)
Oxidoreductases
Cell wall components
Stress response
Sugar/polysacchride
metabolism
General metabolism
Cd36
number
Cd36_83180
Cd36_63190
Cd36_34410
Cd36_21350
Cd36_80440
Cd36_42290
Cd36_12650
Cd36_01150
Cd36_03900
Cd36_07850
Cd36_30670
Cd36_27000
Cd36_19080
Cd36_17750
orf19
number
orf19.320
orf19.5565
orf19.7288
orf19.2262
orf19.5417
orf19.2762
orf19.5005
orf19.3311
orf19.1048
orf19.5113
orf19.5288
orf19.2608
orf19.4504
orf19.5805
Common
Name
Cd36_17740
Cd36_23050
Cd36_64800
Cd36_64610
Cd36_40190
Cd36_40180
Cd36_40510
Cd36_13090
Cd36_29780
Cd36_12490
Cd36_33850
Cd36_01930
Cd36_01850
Cd36_51940
orf19.5806
orf19.220
orf19.1097
orf19.4555
orf19.5636
orf19.5635
orf19.5674
orf19.7218
orf19.535
orf19.4980
orf19.6387
orf19.3664
orf19.4526
orf19.4216
ALD5
PIR1
ALS2
ALS4
RBT5
RBT6
RBT8
RBE1
RBR1
HSP70
HSP104
HSP31
HSP30
HSP122
Cd36_10070
Cd36_03180
Cd36_83590
Cd36_06380
orf19.2344
orf19.3038
orf19.356
orf19.6229
ASR1
TPS2
GST4
CTA1
Annotation
short chain dehydrogenase
homologous to 3-hydroxyisobutyrate dehydrogenase
acetyl-coenzyme-A dehydrogenase
NADPH:quinone reductase | zeta-crystallin
derepressor of telomeric silencing
alkyl hydroperoxide reductase
osmotic growth protein
oxidoreductase
conserved aryl-alcohol dehydrogenase
alcohol dehydrogenase
Zn-containing alcohol dehydrogenase
alcohol dehydrogenase II
alcohol dehydrogenase
mitochondrial D-lactate ferricytochrome c
oxidoreductase
aldehyde dehydrogenase
cell wall structural constituent with tandem repeats
cell wall protein
agglutinin-like protein 4
repressed by TUP1 protein 5
glycosyl- phosphatidylinositol protein | similar to RBT5
glycosyl-phosphatidylinositol protein | similar to RBT5
Cell wall protein; repressed by Efg1
GPI-anchored protein required for filamentous growth
heat shock protein 70
heat shock protein 104
membrane heat shock protein
plasma membrane heat shock protein
heat shock protein
Putative heat shock protein; transcription regulated by
cAMP
threalose-6-phosphate phosphatase
glutathione S-transferase
catalase A, peroxisomal
Cd36_09690
Cd36_42240
Cd36_41060
Cd36_25850
Cd36_70860
Cd36_35570
Cd36_12220
Cd36_01990
Cd36_02000
Cd36_32740
Cd36_04240
Cd36_25650
orf19.4899
orf19.2768
orf19.4682
orf19.3278
orf19.7021
orf19.7676
orf19.4943
orf19.3670
orf19.3672
orf19.734
orf19.6844
orf19.7481
CGA1
AMS1
QUP3
GSY1
GPH1
SOR1
PSA2
GAL1
GAL10
GLK1
ICL1
MDH2
glycoaqmylase involved in beta-1,6-glucan synthesis
vacuolar alpha mannosidase
quinate permease
glycogen(starch) synthase
glycogen phosphorylase
sorbitol dehydrogenase
mannose-1-phosphate guanyltransferase
galactokinase
UDP glucose-4-epimerase
aldohexose specific glucokinase
isocitrate lyase
malate dehydrogenase
ACD99
ZTA1
DOT5
AHP1
OSM2
ADH2
YAL60
ADH5
ADH4
DLD3
Lipid metabolism
Vacuolar proteolysis
Mitochondrial
DNA
metabolism/repair
Hexose transport
Amino acid
metabolism
Secreted/degradative
enzymes
Miscellaneous
Uncharacterised
Cd36_09130
Cd36_33110
Cd36_18350
Cd36_10950
Cd36_01650
Cd36_10110
Cd36_34370
Cd36_51850
Cd36_03120
Cd36_46520
Cd36_20470
Cd36_25170
Cd36_34280
orf19.4833
orf19.6116
orf19.854
orf19.1153
orf19.4543
orf19.2341
orf19.7281
orf19.3171
orf19.3029
orf19.3104
orf19.4114
orf19.7520
orf19.6445
MLS1
GLK4
UGA1
GAD1
UGA22
HNT1
PDK2
ACH1
EHD3
YDC1
FAA2
POT11
ECI1
Cd36_34260
Cd36_81950
Cd36_40880
Cd36_04200
orf19.6443
orf19.1652
orf19.4157
orf19.6838
ECI12
POX1
SPS19
SPS24
Cd36_13270
Cd36_50900
Cd36_21180
Cd36_21670
Cd36_51350
Cd36_04900
Cd36_01500
Cd36_54090
orf19.7242
orf19.4135
orf19.2242
orf19.1891
orf19.1974
orf19.449
orf19.3353
orf19.3931
NCR1
PRC2
PRB1
APR1
TFS1
CIA30
SFC1
malate synthase
aldohexose specific glucokinase
4-aminobutyrate aminotransferase
glutamate decarboxylase
succinate-semialdehyde dehydrogenase
similarity to protein kinase C inhibitor-I
pyruvate dehydrogenase kinase
Acetyl CoA hydrolase
enpyl-CoA hydratase, mitochondrial
alkaline dihydroceramidase
long-chain-fatty-acid CoA ligase
peroxysomal 3-ketoacyl-CoA thiolase A
enoyl-CoA isomerase | d3,d2-Enoyl-CoA Isomerase
enoyl-CoA isomerase | delta3-cis-delta2-trans-enoylCoA isomerase
fatty-acyl coenzyme A oxidase
peroxisomal 2,4-dienoyl-CoA reductase
peroxisomal 2,4- dienoyl-CoA reductase
polytopic membrane protein involved in sterol
homeostasis and trafficking
carboxypeptidase Y precursor
Vacuolar protease
vacuolar aspartic proteinase precursor
carboxypeptidase Y inhibitor
predicted phosphatidyl synthase
possible complex I intermediate associated protein
mitochondrial succinate-fumarate transporter
Cd36_34540
Cd36_23350
Cd36_01970
Cd36_80200
Cd36_01840
Cd36_28770
orf19.7310
orf19.4082
orf19.3668
orf19.5447
orf19.4527
orf19.4384
MSC1
DDR48
HGT2
HGT19
HGT1
HXT10
Meiotic Sister-Chromatid recombination
flocculent specific protein | contains NNDDNSYG motif
hexose transporter
sugar transporter
hexose transporter
fructose symporter
Cd36_83950
Cd36_01580
orf19.2809
orf19.4551
CTN3
YAT1
carnitine acetyltransferase | alcohol metabolism
mitochondrial carnitine acetyltransferase
Cd36_18360
orf19.853
SAP99
Cd36_20100
Cd36_72040
Cd36_73940
Cd36_27990
Cd36_41830
Cd36_43830
Cd36_70500
Cd36_40170
Cd36_06830
Cd36_07580
orf19.6877
orf19.6489
orf19.7140
orf19.2849
orf19.4599
orf19.5307
orf19.7093
orf19.5634
orf19.4438
orf19.5079
PNG2
FMP45
Gpi-anchored aspartic protease
related to peptide-N4-(N-acetyl-beta-D-glucosaminyl)
asparaginase amidase N
conserved hypothetical protein
catechol o- methyltransferase
aquaporin
Na+/Pi symporter
carboxylic acid transporter
sugar transporter-like protein
ferric reductase
zinc-finger transcription factor
ABC transporter
AQY1
PHO89
JEN2
STL12
FRP1
RME1
CDR4
Cd36_50930, Cd36_23410, Cd36_43220, Cd36_10510, Cd36_62800, Cd36_21910, Cd36_72690,
Cd36_01480, Cd36_15880, Cd36_30200,Cd36_01680, Cd36_42230, Cd36_42800, Cd36_23910,
Cd36_15700, Cd36_50140, Cd36_31150, Cd36_54110, Cd36_24050, Cd36_65270, Cd36_81030,
Cd36_18660, Cd36_09560, Cd36_33100, Cd36_32750, Cd36_42520, Cd36_05170, Cd36_01070
Table S6. Genes identified as induced > 2-fold in C. dubliniensis only in response to a shift to
37˚C
Gene Class
Amino acid
metabolism/transport
Cd36 Number
Common
Name
Cd36_15310
Cd36_61160
Cd36_60830
Cd36_06660
Cd36_54920
Cd36_19370
Cd36_40210
Cd36_40700
Cd36_45140
Cd36_65370
Cd36_82300
Cd36_00180
Cd36_44980
Cd36_26410
Cd36_19070
Cd36_86570
ARO8
CAN2
CAN3
GAP4
HIS1
HIS3
HIS4
HIS5
HOM3
ILS1
ILV2
LEU4
LYS1
LYS12
LYS22
LYS9
Miscellaneous
Cd36_07700
Cd36_43760
Cd36_46220
Cd36_54370
Cd36_33650
Cd36_54790
Cd36_27120
Cd36_62120
Cd36_81590
Cd36_50650
Cd36_71880
Cd36_73270
Cd36_04840
Cd36_54320
Cd36_11600
Cd36_20310
Cd36_32540
Cd36_07420
Cd36_07910
Cd36_32190
Cd36_71390
Cd36_52840
Cd36_02040
Cd36_83020
Cd36_44380
Cd36_06880
Cd36_05880
BUL1
ECM1
GUT2
HAS1
NOP10
PCL5
PHO113
PLB2
PPT1
THR1
LIG1
DED81
GPT1
MES1
WRS1
IDP1
MIS11
ADE5,7
GCV2
SEO1
NUP
TNA1
ABP140
AIP2
BAS1
CPH1
UME6
tRNA synthesis
General Metabolism
Permeases
Cell motility/budding
Transcription Factor
Annotation
Aromatic transaminase of aromatic alcohol biosynthesis
Putative amino acid permease
Putative amino acid permease
Putative amino acid permease
Enzyme of histidine biosynthesis
Enzyme of histidine biosynthesis
Enzyme of histidine biosynthesis
Putative histidinol-phosphate aminotransferase
Putative L-aspartate 4-P-transferase
Protein similar to isoleucyl-tRNA synthetase
Protein described as acetolactate synthase
Putative 2-isopropylmalalate synthase
Saccharopine dehydrogenase, enzyme of lysine biosynthesis pathway
Protein described as mitochondrial homoisocitrate dehydrogenase
Putative homocitrate synthase
Putative enzyme of lysine biosynthesis
Similar to S. cerevisiae Bul1p, which may be involved in selection of
substrates for ubiquitination
Induced by heavy metal (cadmium) stress; Hog1p regulated
Predicted ORF in Assemblies 19, 20 and 21
Putative DEAD-box RNA helicase
Small nucleolar ribonucleoprotein
Protein similar to S. cerevisiae Pcl5p
Protein described as a constitutive acid phosphatase
Putative phospholipase B
Protein described as serine/threonine phosphatase
Putative homoserine kinase
tRNA ligase
Putative tRNA-Asn synthetase
GABA/polyamine transporter
Cytoplasmic methionyl-tRNA synthetase (MetRS)
Putative tRNA-Trp synthetase
Protein described as isocitrate dehydrogenase
Putative mitochondrial C1-tetrahydrofolate synthase
Enzyme of adenine biosynthesis
Putative protein of glycine catabolism
Major facilitator superfamily (MFS) transporter
Nucleoside permease for adenosine and guanosine
Putative nicotinic acid transporter
Protein similar to S. cerevisiae actin-binding protein
Protein described as an actin interacting protein
Transcription factor with Myb-like DNA-binding motif
Transcription factor for hyphal growth on solid media
Transcription required for hyphal elongation
Cell Wall
Stress Response
Cd36_64210
Cd36_33470
ALS1
YHB5
Adhesin; ALS family of cell-surface glycoproteins
Protein related to flavohemoglobins
Uncharacterised
Cd36_02770, Cd36_08390, Cd36_11670, Cd36_12430, Cd36_12710, Cd36_15360, Cd36_16750,
Cd36_20320, Cd36_20600, Cd36_23450, Cd36_23740, Cd36_24620, Cd36_25100, Cd36_26980,
Cd36_30120, Cd36_30270, Cd36_32010, Cd36_32660, Cd36_40980, Cd36_41340, Cd36_43460,
Cd36_44910, Cd36_45290, Cd36_50340, Cd36_50750, Cd36_54450, Cd36_54680, Cd36_62230,
Cd36_70150, Cd36_73000, Cd36_80300, Cd36_81270, Cd36_81400, Cd36_84450, Cd36_86070
Table S7. Genes induced > 2-fold following nutrient depletion in C. dubliniensis
Gene Class
Amino acid and protein
degradation
Nitrogen Uptake
carbohydrate uptake and
catabolism
Cell wall biosynthesis
Cell surface proteins
Cd36 Number
Common
Name
Cd36_84150
Cd36_61780
Cd36_29830
Cd36_10900
Cd36_34360
Cd36_20100
Cd36_50900
Cd36_70380
Cd36_12840
Cd36_04400
Cd36_85550
Cd36_27190
Cd36_17580
AFP99
CAR1
LAP3
MET2
NIT2
PNG2
PRC2
VPS70
DAL7
DUR3
GAP2
IFC3
UGA4
Cd36_42240
Cd36_22310
Cd36_63660
Cd36_32740
Cd36_33110
Cd36_52690
Cd36_25850
Cd36_70490
Cd36_29090
Cd36_54530
Cd36_27900
Cd36_52470
Cd36_35570
Cd36_85780
Cd36_27860
Cd36_13040
Cd36_09690
Cd36_52400
Cd36_02500
Cd36_52340
Cd36_81610
Cd36_82120
Cd36_64210
Cd36_23630
Cd36_52240
Cd36_25710
Cd36_45820
Cd36_15090
Cd36_46450
Cd36_29780
Cd36_43400
AMS1
ARA1
GLC3
GLK1
GLK4
GRE3
GSY1
HGT12
HGT3
MAL31
PGM2
XYL1
XYL2
ALG5
EXG2
GCA1
MNN1
MNN44
MNT4
UTR2
ALS1
EAP1
ECM331
IFF4
PGA43
PGA52
PRA1
RBR1
RBT1
Annotation
Protein described as related to arginases
Responsible for arginine degradation
Protein described as an aminopeptidase
Similar to A. nidulans CYSA serine O-trans-acetylase
hydrolase activity, acting on carbon-nitrogen bonds
Peptide-n4-(n-acetyl-beta-d-glucosaminyl) asparaginase amidase
Protein described as a carboxypeptidase
glutamate carboxypeptidase, putative
Putative allantoate permease
Putative urea transporter
Protein similar to amino acid permeases
Oligopeptide transporter
gamma-aminobutyrate (GABA) transport protein
Vacuolar alpha mannosidase, involved in oligosaccharide
degradation
D-Arabinose dehydrogenase
glycogen-branching enzyme, putative
Putative glucokinase
Protein described as a glucokinase
Similar to D-xylose reductases
Protein described as glycogen synthase
Glucose, fructose and mannose major facilitator transporter;
Putative glucose transporter of the major facilitator superfamily
Maltose permease, high-affinity maltose transporter
Similar to S. cerevisiae Pgm2p, which is phosphoglucomutase
Xylitol dehydrogenase, converts xylitol to D-xylulose
Protein described as similar to D-xylulose reductase
Negative regulator of gluconeogenesis
Putative glucosyltransferase involved mannan biosynthesis
Protein described as similar to glucan 1,3-beta-glucosidase
Predicted plasma membrane-associated glucoamylase
Putative alpha-1,3-mannosyltransferase
mannosylphosphorylation of N-linked oligosaccharides
alpha-1,3-mannosyltransferase, putative
Putative cell-surface glycosidase
Putative mannan endo-1,6-alpha-mannosidase precursor
Adhesin; ALS family of cell-surface glycoproteins
Cell wall adhesin required for adhesion and biofilm formation
Putative GPI-anchored protein
Putative GPI-anchored protein
Putative GPI-anchored protein
Putative GPI-anchored protein
Cell surface protein, enriched at hyphal tips
GPI-anchored cell wall protein required for filamentous growth
Putative cell wall protein with similarity to Hwp1p
Ion homeostasis
Cd36_54185
Cd36_32930
Cd36_27310
Cd36_26350
Cd36_41000
Cd36_17380
Cd36_16960
CUP1
FRE6
GEF2
HOL3
SMF1
ZRT2
ZRT3
Stress response
Cd36_18070
Cd36_02230
Cd36_23350
Cd36_20830
Cd36_16780
Cd36_70560
Cd36_31940
Cd36_05570
CHK1
PSO2
DDR48
RTA2
SFD1
Cd36_61180
Cd36_31730
Cd36_05880
Cd36_30830
Cd36_44490
Cd36_34590
Cd36_17970
CIP1
ZCF19
UME6
SUA72
CSR1
SUC1
STP4
Cd36_85720
Cd36_27000
Cd36_53880
Cd36_25260
Cd36_63800
Cd36_01150
Cd36_07850
Cd36_85770
CRZ1
ADH5
SOX2
ALK3
GRE2
IFD3
ADH2
FMO1
Cd36_41960
Cd36_62120
Cd36_18360
Cd36_11420
Cd36_84360
PHO114
PLB2
SAP99
BUL2
HUL4
Cd36_85340
PIM1
Cd36_23100
AVO2
Cd36_12480
KNS1
Cd36_42040
GPB1
Cd36_01680
Cd36_70160
Cd36_82280
Cd36_73150
Cd36_05380
RDI1
FGR2
FGR23
GYP7
AUT7
Transcription factor
oxidoreductase
Secreted/degradative
enzymes
Protein fate
Signaling/kinases/phosph
atases
Cell motility/budding/cell
division
ER/Golgi/secretion
GST3
SIP5
Metallothionein, involved in copper resistance
similar to ferric reductase Fre10p
Voltage-gated chloride channel, putative
Predicted ORF
divalent metal ion transporter, putative
Protein described as predicted zinc transporter
Protein described as predicted zinc transporter
Histidine kinase involved in a two-component signaling pathway that
regulates cell wall biosynthesis
Predicted ORF
Immunogenic stress-associated protein
Stress-associated protein
Protein not essential for viability, Stress response DeFective
Induced in core stress response
Expression is regulated upon white-opaque switching
Putative transcription factor with zinc finger DNA-binding motif
NmrA-like family protein, involved in nitrogen metabolite repression
in fungi
Predicted zinc-finger protein of unknown function
Transcription factor required for hyphal elongation
Predicted transcriptional regulator
Putative zinc-finger transcription factor involved in zinc homeostasis
Putative transcriptional regulator with N-terminal zinc finger
Putative transcription factor with zinc finger DNA-binding motif
Transcription factor; similar to S. cerevisiae calcineurin-regulated
transcription factor Crz1p
Putative alcohol dehydrogenase
Putative benzene desulfurase
N-alkane inducible cytochrome P-450, putative
NADPH-dependent methylglyoxal reductase
Aryl-alcohol dehydrogenase
Putative alcohol dehydrogenase
Putative oxidoreductase
Putative acid phosphatase
Putative phospholipase B
Putative secreted aspartyl protease
E3-ubiquitin ligase complex subunit, putative, GAP1 sorting!
Protein with similarity to hect domain E3 ubiquitin-protein ligases
ATP-dependent Lon protease, involved in degradation of misfolded
proteins in mitochondria
Homology to yeast AVO2, Tor interacting protein
Protein not essential for viability; similar to S. cerevisiae Kns1p,
which is a protein kinase
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream
of Gpa2p and Cyr1p
Rho GDP dissociation inhibitor involved in the localization and
regulation of Cdc42p and Rho1p
Protein similar to phosphate transporters
Transposon mutation affects filamentous growth
Vesicular protein trafficking Rab GTPase-activating protein, putative
autophagy-related protein 8 precursor ATG8, putative
Lipid metabolism
Miscellaneous
Uncharacterized
Cd36_15680
Cd36_72700
Cd36_12610
Cd36_43730
Cd36_22420
Cd36_15230
Cd36_34930
Cd36_29040
Cd36_80890
TGL1
PHS1
CYB2
EEP1
UCF1
STF2
IFA14
PRP13
triglyceride lipase-cholesterol esterase, putative
Involved in sphingolipid biosynthesis and protein trafficking
cytochrome b2, mitochondrial precursor, putative
endonuclease/exonuclease/phosphatase family protein, putative
Up-regulated by CAMP in Filamentous growth
Protein involved in ATP biosynthesis
Putative LPF family protein
Predicted ORF
hypothetical LPF family protein, pseudogene, putative
Cd36_65240, Cd36_43450, Cd36_16310, Cd36_82530, Cd36_40910, Cd36_09640, Cd36_12330,
Cd36_72270, Cd36_13010, Cd36_85650, Cd36_33100, Cd36_32750, Cd36_05170, Cd36_03910,
Cd36_03920, Cd36_53460, Cd36_45480, Cd36_19320, Cd36_15700, Cd36_81030, Cd36_82780,
Cd36_42230, Cd36_42220, Cd36_46120, Cd36_46100, Cd36_54110, Cd36_08780, Cd36_08810,
Cd36_09560, Cd36_20250, Cd36_24630, Cd36_63380, Cd36_63640, Cd36_84070, Cd36_84270
Cd36_06620, Cd36_30360, Cd36_34310, Cd36_71340, Cd36_31150, Cd36_87000, Cd36_34545,
Cd36_86070, Cd36_04650, Cd36_34810, Cd36_24360, Cd36_22590, Cd36_28820, Cd36_01770,
Cd36_20260, Cd36_85970, Cd36_15880, Cd36_18660, Cd36_01480, Cd36_81460, Cd36_22860,
Cd36_04900, Cd36_73440, Cd36_70980, Cd36_80010, Cd36_25010, Cd36_50010, Cd36_00010
Table S8. Genes repressed > 2-fold following nutrient depletion in C. dubliniensis
Gene Class
Cell Surface
Secreted enzymes
Transport
Iron Uptake
Cell cycle
General metabolism
Miscellaneous
Uncharacterised
Cd36 number
Cd36_86290
Cd36_64220
Cd36_60170
Cd36_07060
Cd36_13090
Cd36_22720
Cd36_85220
Cd36_04610
Cd36_03630
Cd36_45880
Cd36_72090
Cd36_02400
Cd36_34560
Cd36_73910
Cd36_08290
Cd36_60410
Cd36_19580
Cd36_40170
Cd36_27290
Cd36_82710
Common
Name
ALS6
ALS9
PGA25
PRY1
RBE1
YWP1
SAP3
SAP7
SEN15
SOU1
YPS7
PUT4
SSU1
TPO2
TPO3
FET3
FRE9
FRP1
KAR4
SMC3
Cd36_63950
Cd36_35120
Cd36_64170
Cd36_20820
Cd36_05820
Cd36_86810
POL5
INO1
PAD1
RTA3
BUD16
FCR1
Annotation
ALS family protein
ALS family protein
Putative GPI-anchored protein of unknown function
Transcription is opaque specific
Putative cell wall protein
Protein with suggested role in dispersal in host
Secreted aspartyl proteinase
Member of the secreted aspartyl proteinase family
Similar to delta subunit of tRNA splicing endonuclease
Enzyme involved in utilization of L-sorbose; sorbitol dehydrogenase
Putative aspartic-type endopeptidase
Putative proline permease
Protein similar to S. cerevisiae Ssu1p sulfite transport protein
Putative polyamine transport protein
Possible role in polyamine transport; MFS-MDR family
Multicopper oxidase; required for growth under low-iron conditions
Protein similar to ferric reductase Fre10p
Protein similar to ferric reductases
Protein similar to S. cerevisiae Kar4p, which has a role in karyogamy
Similar to S. cerevisiae Smc3p, which is an ATPase involved in sister
chromatid cohesion
Similar to S. cerevisiae POL5
Inositol-1-phosphate synthase; enzyme of inositol biosynthesis
Protein described as phenylacrylic acid decarboxylase
Similar to S. cerevisiae Rta1p and Rsb1p (flippase)
Protein similar to S. cerevisiae Bud16p
Zinc cluster transcription factor; negative regulator of fluconazole
resistance
Cd36_00770, Cd36_03950, Cd36_05550, Cd36_05910, Cd36_07410, Cd36_08960, Cd36_10140,
Cd36_10360, Cd36_11450, Cd36_12810, Cd36_16290, Cd36_16490, Cd36_16630, Cd36_16980,
Cd36_19760, Cd36_20300, Cd36_20670, Cd36_20880, Cd36_21050, Cd36_21280, Cd36_22440,
Cd36_22650, Cd36_22840, Cd36_23450, Cd36_23460, Cd36_24680, Cd36_29080, Cd36_32000
Cd36_32520, Cd36_34350, Cd36_40970, Cd36_41230, Cd36_41240, Cd36_42690, Cd36_43040,
Cd36_43120, Cd36_43280, Cd36_44650, Cd36_45020, Cd36_46630, Cd36_52760, Cd36_53900,
Cd36_54590, Cd36_62580, Cd36_63560, Cd36_63710, Cd36_63910, Cd36_70550, Cd36_70940,
Cd36_71260, Cd36_71960, Cd36_72080, Cd36_81270, Cd36_85590, Cd36_85710, Cd36_86490,
Cd36_86890, Cd36_87040