Download Molecular Biology:

Biology
Mutations
Mutation:
Sample DNA sequence
TAC GTA C
TA GCG TCT TGG GCT TAG ATC
The large T in the DNA sequence is mutated. What mutations are possible?
Types of Mutations
Substitution:
Insertion:
Deletion:
What effect do mutations have?
1. No effect, for example:
2. change _______________
3.
4. change reading frame
Reading Frame:
Biology
Mutations
Insertion Mutations
Original DNA sequence: TAC GTA CTA GCG TCT TGG GCT TAG ATC
Original RNA sequence: AUG CAU GAU CGC AGA ACC CGA AUC UAG
Original amino acid sequence:
Insertion of A: TAC GTA C
ATA GCG TCT TGG GCT TAG ATC
New reading frame:
New RNA sequence:
New amino acid sequence:
Deletion Mutations
Original DNA sequence: TAC GTA CTA GCG TCT TGG GCT TAG ATC
Original RNA sequence: AUG CAU GAU CGC AGA ACC CGA AUC UAG
Original amino acid sequence:
Deletion of T: TAC GTA CTA GCG TCT TGG GCT TAG ATC
New reading frame:
New RNA sequence:
New amino acid sequence:
Chromosomal Abnormalities
Duplication
Deletion
Inversion
Biology
Mutations
Codon Table