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DOC/LP/01/28.02.02
LP- BT6201
LESSON PLAN
LP Rev. No: 00
Sub Code & Name:
Unit: I
BT6201
BIOCHEMISTRY I
Branch: Biotechnology
Date: 20.01.14
Page 1 of 6
Semester: II
UNIT I BIOCHEMICAL ORGANIZATION AND BIOENERGETICS
10 (12)
Scope of clinical biochemistry, component of the cell, structure and biochemical functions,
membrane structure and functions, transport through biological cell membrane, the concept of free
energy, determination of change in free energy from equilibrium constant and reduction potential,
bioenergetics and biological oxidation – general concept of oxidation and reduction, electron
transport chain, oxidative phosphorylation, uncouplers and theories of biological oxidation and
oxidative phosphorylation
OBJECTIVE: To know about the cell and its biochemical functions
Session
No
Topics to be covered
Time
(min.)
1
Introduction to Biochemistry, Scope of
clinical biochemistry
50
2
Component of the Cell
50
3
Structure and Biochemical Functions of Cell
50
4
Membrane Structure and Functions
50
5
50
9
Transport
through
Biological
Cell
Membrane
Transport
through
Biological
Cell
Membrane
The Concept of Free Energy, Determination
of Change in Free Energy From Equilibrium
Constant
Bioenergetics and Biological Oxidation –
General Concept of Oxidation and Reduction
Reduction Potential
10
Text
Book/
Ref
Book
RB 5
TB 1
Page No
1 -9
Teaching
Method
BB/OHP
1-12
SMART
BOARD
3-19
SMART
BOARD
370-380
BB/OHP
TB 1
389-402
BB/OHP
50
TB 1
402-416
50
TB 1
490-495
SMART
BOARD
BB/OHP
50
TB 1
507-509
50
TB 1
509-512
Electron Transport Chain
50
TB 1
512-516
11
Oxidative Phosphorylation, Uncouplers
50
TB 1
691-704
12
Theories of Biological Oxidation
Oxidative Phosphorylation
50
TB 1
704-716
6
7
8
and
1
RB 3
TB 1
SMART
BOARD
BB/OHP
SMART
BOARD
SMART
BOARD
BB/OHP
DOC/LP/01/28.02.02
LESSON PLAN
LP- BT6201
LP Rev. No: 00
Date: 20.01.14
Sub Code & Name:
Unit: II
BT6201
BIOCHEMISTRY I
Branch: Biotechnology
Semester: II
Page 2 of 6
UNIT II BIOMOLECULES
12 (16)
Carbohydrates – classification, properties.starch, glycogen, dextrin, inulin, cellulose, metabolism of
carbohydrates – gluconeogenesis, glycogenolysis, glycolysis. citric acid cycle and its biological significance,
role of sugar in nucleotide biosynthesis and pentose phosphate pathway.
Lipids – Classification, properties. sterols, essential fatty acids, eicosanoids, phospholipids, sphingolipids,
metabolism of lipids, oxidation of fatty acids, α,β - oxidation and biosynthesis of ketone bodies, cholesterol,
porphyrin biosynthesis, metabolism of bile pigments.
Proteins and amino acids – Classification, properties, biosynthesis of amino acids and proteins, essential
amino acids, metabolism of amino acids and proteins, Nitrogen balance.
Nucleic acids –genetic code, nucleic acids, and structure of DNA and RNA, purine biosynthesis and
pyrimidine biosynthesis
OBJECTIVE: To discuss in detail about the structures and properties of carbohydrates, lipids, proteins and
Nucleic acids
Session
No
13
Topics to be covered
18
Carbohydrates – Classification, Properties
Starch,
Glycogen,
Dextrin,
Inulin,
Cellulose
Metabolism
of
Carbohydrates
–
Gluconeogenesis, Glycogenolysis
Glycolysis
Citric Acid Cycle And Its Biological
Significance
Role of Sugar in Nucleotide Biosynthesis
and Pentose Phosphate Pathway
19
Lipids – Classification, Properties
14
15
16
17
20
21
22
23
24
25
26
27
28
Sterols, Essential Fatty Acids, Eicosanoids,
Phospholipids, Sphingolipids
Metabolism of Lipids, Oxidation of Fatty
Acids, α,β – Oxidation, Biosynthesis of
Ketone bodies
Biosynthesis of Cholesterol
Porphyrin Biosynthesis, Metabolism of
Bile Pigments
Proteins and Amino Acids –
Classification, Properties
Biosynthesis of Amino Acids and Proteins,
Essential Amino Acids
Metabolism of Amino Acids and Proteins,
Nitrogen Balance
Nucleic acids –Genetic Code, Nucleic
Acids, and Structure of DNA and RNA
Purine Biosynthesis, Pyrimidine
Biosynthesis
Time
(min)
50
50
50
50
50
50
50
50
Ref
Page No
Teaching Method
TB 1
RB 5
239-255
49-51
BB/OHP
TB 2
157-173
TB 2
TB 2
149-156
SMART BOARD
143-147
SMART BOARD
TB 2
174-182
RB 5
55-57
RB 5
57-68
TB 2
184-192
SMART BOARD
TB2
TB 2
224-233
271-283
SMART BOARD
SMART BOARD
RB 4
54-61
BB/OHP
TB 2
234-238
BB/OHP
TB 2
239-246
SMART BOARD
BB/OHP
SMART BOARD
SMART BOARD
BB/OHP
BB/OHP
50
50
50
50
50
50
50
50
2
RB 5
TB 2
97-101
292-300
BB/OHP
SMART BOARD
DOC/LP/01/28.02.02
LP- BT6201
LESSON PLAN
LP Rev. No: 00
Sub Code & Name:
Unit: III
BT6201
BIOCHEMISTRY I
Branch: Biotechnology
Semester: II
Date: 20.01.14
Page 3 of 6
UNIT III BIOENERGETICS
5
High energy compounds, electronegative potential of compounds, respiratory chain, ATP cycle,
Calculation of ATP during oxidation of glucose and fatty acids.
OBJECTIVE: To discuss in detail about the energy produced by biological molecules during
metabolism.
Session
No
Topics to be covered
Time
(min)
29
High Energy Compounds
50
30
Electronegative Potential of
Compounds
50
31
Respiratory Chain
50
32
ATP Cycle
50
33
Calculation of ATP During
Oxidation of Glucose and Fatty
acids.
Ref
RB 4
Page No
229-231
RB 4
231-233
TB 2
103-109
TB 1
704-716
Teaching
Method
BB/OHP
BB/OHP
BB/OHP
BB/OHP
TB 2
50
3
155
BB/OHP
DOC/LP/01/28.02.02
LP- BT6201
LESSON PLAN
LP Rev. No: 00
Sub Code & Name:
Unit: IV
BT6201
BIOCHEMISTRY I
Branch: Biotechnology
Semester: II
Date: 20.01.14
Page 4 of 6
UNIT IV MACROMOLECULES, VITAMINS, HORMONES, ENZYMES
10 (16)
Physical and chemical properties, structure of haemoglobin, immunoglobulins and nucleoprotein,
classification and their properties, occurrence, functions, requirements, deficiency manifestations
and role of vitamins as coenzyme, chemical nature and properties, hormones, Nomenclature,
enzyme kinetics, classification and their properties, mechanism of action, enzyme induction and
inhibition, coenzyme significance and enzymes of clinical importance
OBJECTIVE: To impart knowledge on other macromolecules, micro molecules, hormones and its
function.
Session
No
34
Topics to be covered
Physical and Chemical Properties,
Structure of Hemoglobin
Time
50
35
Immunoglobulins
50
36
Immunoglobulins
50
37
Nucleoprotein
Occurrence, Functions,
Requirements, Deficiency
Manifestations and Role of
Vitamins as Coenzyme
Occurrence, Functions,
Requirements, Deficiency
Manifestations and Role of
Vitamins as Coenzyme
Occurrence, Functions,
Requirements, Deficiency
Manifestations and Role of
Vitamins as Coenzyme
Chemical Nature And Properties,
Hormones
Chemical Nature And Properties,
Hormones
Chemical Nature And Properties,
Hormones
50
44
Nomenclature, Enzyme Kinetics
50
45
Classification and Their Properties
50
46
Mechanism of Action
50
47
Enzyme induction and Inhibition
48
Coenzyme Significance
49
Enzymes of Clinical Importance
38
39
40
41
42
43
50
Ref
RB 6
RB 5
RB 2
RB 5
RB 2
Page No
186-189, 365-377
102-109
922-926
457-461
RB 5
RB 6
RB 4
100-101
926-929
Teaching
Method
SMART
BOARD
SMART
BOARD
SMART
BOARD
BB/OHP
396-427
170-180
BB/OHP
180-192
BB/OHP
192-200
BB/OHP
498-511
BB/OHP
RB4
50
RB4
50
50
50
50
50
50
50
4
RB4
RB 4
511-522
RB4
522-538
RB 6
RB 4
RB 6
RB 4
RB 6
RB 4
RB 6
RB 4
RB 6
RB 4
RB 6
RB 4
198-211, 43-47
139-157, 159
211-222, 37-38
159-161
40-43
142-146
47-50
157-161
38-39
146- 148
54-60
157-158
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
DOC/LP/01/28.02.02
LP- BT6201
LESSON PLAN
LP Rev. No: 00
Sub Code & Name:
Unit: V
BT6201
BIOCHEMISTRY I
Branch: Biotechnology
Date: 20.01.14
Page 5 of 6
Semester: II
UNIT V BIOCHEMISTRY OF CLINICAL DISEASES
8 (11)
Diabetes mellitus, atherosclerosis, fatty liver, and obesity, hormonal disorders, aging, inborn errors
of metabolism organ function tests
OBJECTIVE: To impart knowledge biochemical basis of degenerative diseases.
Session
No
Topics to be covered
Time
(min)
50
50
Diabetes mellitus
51
Atherosclerosis
50
52
53
Fatty liver
Obesity
50
50
54
Hormonal Disorders
50
55
Hormonal Disorders
56
Aging
50
50
57
Inborn Errors of Metabolism
58
Organ Function Tests
59
60
Organ Function Tests
Organ Function Tests
50
50
50
50
5
Ref
RB 5
RB 6
RB 5
RB 5
RB 5
RB 6
RB 5
RB 5
Internet
Sources
RB 5
RB 6
RB 5
RB 6
RB 6
Page
No
270-271
177-179
528
299
504-506
537-549
462-470
462-485
---449-454
517-536
581-586
517-524
524-536
Teaching
Method
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
BB/OHP
DOC/LP/01/28.02.02
LP- BT6201
LESSON PLAN
LP Rev. No: 00
Sub Code & Name:
BT6201
Date: 20.01.14
BIOCHEMISTRY I
Branch: Biotechnology
Page 6 of 6
Semester: II
Course delivery plan:
WEEK
UNITS
1
2
3
4
5
I
6
7
II
8
III
9
10
11
12
13
IV
14
15
V
EACH WEEK: 4 HRS
TOTAL: 45 (60) PERIODS
TEXT BOOKS
1. Lehninger A.L., Nelson D.L. and Cox M.M. Principles of Biochemistry. CBS publishers and
distributers
2. Murray R.K., Granner D.K., Mayes P.A. and Rodwell V.W. Harpers Biochemistry. Appleton and
Lange ,Stanford ,Conneticut.
3. Thomas M. Devlin.Textbook of Biochemistry with clinical correlations. Wiley Liss Publishers
REFERENCES
1. Burtis & Ashwood W.B. Tietz Textbook of Clinical chemistry. Saunders Company
2. Lubert Stryer W.H. Biochemistry. Freeman and company, New york.
3. Donald Voet & Judith G. Voet. Biochemistry. John Wiley and Sons ,Inc.
4. Rama Rao Textbook of Biochemistry
5. Deb. Textbook of Biochemistry
6. DM.Vasudevan Sri Kumari, Text Book of Biochemistry for Medical Students, Jaypee Brothers
Medical publication
Prepared by
Approved by
Dr. S. Prabhu
Prof. Sulochana Somasundaram
Associate Professor (BT)
HOD of Biotechnology
20.01.14
20.01.14
Signature
Name
Designation
Date
6
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