Download PERSONAL - Stanford University

CURRICULUM VITAE
William Thomas Clusin, M.D., Ph.D.
PERSONAL
Home Address:
Birthdate:
Children:
EDUCATION
Medical
June 1970June 1976
College
Sept. 1966June 1970
946 Valdez Place, Stanford, CA 9430
March 31, 1949
Three sons born 1982, 1985, 1990
M.D. and Ph.D in Neuroscience, Albert Einstein College of
Medicine, Bronx, NY, Medical Scientist Training Program
Bachelor of Science, Massachusetts Institute of Technology,
Cambridge, MA
PROFESSIONAL APPOINTMENTS
1994-present
Attending Physician Palo Alto VA Hospital
1993-1994
Visiting Associate Professor of Medicine
University of California at San Francisco (Sabbatical)
1990
Visiting Associate Professor of Physiology
University of California at Irvine
1988-present
Associate Professor of Medicine
Stanford University School of Medicine
1988-1990
Associate Professor of Molecular Physiology
Stanford University School of Medicine
1987-1988
Assistant Professor of Medicine and Physiology
Stanford University School of Medicine
1983-1988
Assistant Professor of Medicine (Cardiology)
Stanford University School of Medicine
1981-present
Attending Cardiologist
Stanford University Medical Center
1980-1981
Senior Resident in Medicine
Stanford University Medical Center
1978-1980
Fellow in Cardiology
Stanford University Medical Center
1976-1978
Intern and Junior Resident in Medicine
Stanford University Medical Center
HONORS AND AWARDS
2001
Medal of Merit; XVII World Congress of the International Society
For Heart Research
2001
Fellow of the American Heart Association; Council on Basic
Science
1999
Professional Partners Society, American Liver Foundation
1998
Fellow of the American College of Physicians
1987
American Society for Clinical Investigation
1984-1989
Established Investigator of the American Heart Association
1979-1980
Evelyn L. Neizer Foundation Award, Stanford University
1978-1979
American Heart Association Post-Doctoral Fellowship
William Thomas Clusin, M.D., Ph.D.
1976
1974
1970
1970-1976
1970-1977
Curriculum Vitae
2
Alpha Omega Alpha Medical Honor Society
Epilepsy Foundation of American Research Award
NSF Pre-Doctoral Fellowship (not used)
NIH Pre-Doctoral Fellowship
National Merit Scholar
BOARD CERTIFICATION AND LICENSURE
Diplomate, American Board of Internal Medicine, Subspecialty of Cardiovascular
Disease (#082176), 1995.
Diplomate, American Board of Internal Medicine (#082176), 1982
Licensed Physician, State of California (#G035051)
Diplomate, National Board of Medical Examiners, 1977
ADDITIONAL TRAINING:
1980-1981
Post Fellowship Training in Clinical Cardiac Electrophysiology
CLINICAL ADMINISTRATION AND OTHER DUTIES
2000-present
1981-present
1994-present
1994-1996
1994-1998
1985-1992
Clinical Director, Stanford Electrocardiography Laboratory
Stanford University Hospital
Stanford University Hospital Outpatient Clinics
Palo Alto VA Hospital Outpatient Clinics
Monterey VA Hospital Outpatient Clinics, Seaside, California
Livermore VA Hospital Outpatient Clinics
Medical Credentials Committee; Medical Service; Stanford University
Hospital
SOCIETY MEMBERSHIPS
1978
Society of General Physiologists
1978
Biophysical Society
1982
Associate Fellow of the American College of Cardiology
1982
Member of the American College of Physicians
1983
Cardiac Electrophysiological Society
1983
Council on Basic Science, American Heart Association
1984
International Society for Heart Research
1990
American Association for the Advancement of Science
1992
Council on Clinical Cardiology, American Heart Association
EDITORIAL EXPERIENCE
1988-1992
Associate Editor, Journal of Clinical Investigation
1989-1994
Editorial Board Member, Circulation Research
2004Editorial Consultant, American College of Physicians, PIER Online
Publication Program; Sudden Cardiac Death
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
3
ABSTRACT GRADER
American Heart Association, Annual Scientific Sessions
American College of Cardiology, Scientific Sessions
American Society for Clinical Investigation, Coordinating Reviewer
PRIMARY REFEREE (approx. 250 papers):
American Heart Journal
American Journal of Cardiology
American Journal of Physiology
Basic Research in Cardiology
Basic Research in Biochemical Pharmacology
Biophysical Journal
Cardiovascular Drugs and Therapy
Cardiovascular Research
Cell Biochemistry and Function
Critical Reviews in Clinical Laboratory Sciences
Circulation
Circulation Research
European Journal of Cardiology
European Journal of Pharmacology
European Journal of Physiology
Journal of the American College of Cardiology
Journal of Cardiovascular Pharmacology
Journal of Clinical Investigation
Journal of Experimental Biology and Medicine
Journal of Molecular and Cellular Cardiology
Journal of the National Cancer Institute
Journal of Pharmacology & Experimental Therapeutics
Journal of Physiology (London)
Neuroscience Letters
Pace
Pharmacological Research (Milan)
Physiological Reviews
TRAINING GRANTS
1993-9
Program Director: NIH Training Program in Cardiac and Cellular
Electrophysiology - (14 Trainees Funded).
POSTDOCTORAL FELLOWS
(Funded externally under Dr. Clusin’s sponsorship)
1982-1983
Maurice Buchbinder, M.D.
Canadian Heart Foundation
1983-1985
R. Hardwin Mead, M.D.
U.S. Public Health Service
1984-1985
Joseph Ilvento, M.D.
U.S. Public Health Service
1984-1986
Kathleen Blake, M.D.
U.S. Public Health Service
1985-1988
Hon-Chi Lee, M.D., Ph.D
California Heart Association
1985-1987
Nellis Smith, M.D.
U.S. Public Health Service
1985-1987
Rajendra Mohabir, Ph.D
Canadian Heart Association
1987-1989
Rajendra Mohabir, Ph.D
California Heart Association
William Thomas Clusin, M.D., Ph.D.
1986-1988
1988-1989
1989-1990
1988-1990
1988-1990
1989-1990
1991-1993
1993-1994
1994-1995
1997-2002
Thomas McDonald, M.D.
Walter Chien, M.D.
Walter Chien, M.D.
Michael Lauer, M.D., Ph.D.
Xiao-li Ren, M.D., Ph.D.
Robert Kurz, M.D.
Mark Anderson, M.D., Ph.D.
Mark Anderson, M.D., Ph.D.
Wu Yi Ming, M.D.
You-wen Qian, MD
Curriculum Vitae
4
U.S. Public Health Service
Merck/ACC Fellowship
California Heart Association
California Heart Association
Ho Tim-Stanley Ho Foundation
Max Kade Foundation
California Heart Association
U.S. Public Health Service
NIH RO1 Funds
Sung Pharmaceutical Fund;
Chen Family Foundation
MEDICAL SCHOOL COURSE DIRECTOR:
1991-1993:
Course Co-Director. Cardiac Physiology Course
Stanford University School of Medicine
1990
Principal Lecturer and Course Director, Cardiovascular Physiology
Course; School of Medicine; University of California at Irvine
PEER REVIEW COMMITTEES AND SCIENTIFIC SESSIONS:
LOCAL AND NATIONAL
1984-1995
Co-Organizer, Bay Area Electrophysiology Group
1985-1987
Committee for the Protection of Medical Human Subjects of
Stanford University
1985 -2001
Ad-hoc Reviewer, Veterans Administration, Merit Review Program
1986 -1991
Peer Review Committee, California Heart Association
1987
Ad-hoc Reviewer, Cardiovascular and Pulmonary Study Section,
National Heart, Lung and Blood Institute
1988 -1992
Regular Member, Cardiovascular and Renal Study Section,
National Heart, Lung and Blood Institute
1989
Ad-hoc Reviewer, Cardiovascular Research Program
Development Award, American Heart Association
1989 -1992
Stanford Medical Student Scholars Committee
1990
Ad-hoc Reviewer, Tobacco Related Disease Research Program,
University of California
1990 Interviewer - Stanford Medical School Admissions Committee
1991-1992
Ad-hoc Reviewer, Program Project Study Section, National
Heart, Lung and Blood Institute
1992
Committee on Scientific Sessions Program of the American
Heart Association
1992 -1995
Grant in Aid Study Section of the American Heart Association.
1996 -1998
Examination Question Writer: American Board of Internal Medicine
Certifying Examination
1997
Ph.D Dissertation Ad-hoc Committee, Stanford University, Dept. of
Neuroscience; University Chair
1998; 2000
Ph.D Dissertation Ad-hoc Commitee, Stanford University, Dept. of
Neuroscience; University Chair
1998, 2000
Program Committee; Biophysical Society
1998Committee for the Protection of Medical Human Subjects; Stanford
University
William Thomas Clusin, M.D., Ph.D.
1999
1999, 2001
2003
Curriculum Vitae
5
PhD Dissertation Ad Hoc Committee, Stanford University;
Department of Molecular Physiology; University Chair
Ad- hoc Reviewer, Pathology Study Section A, National Heart Lung
and Blood Institute
Dean’s Fellowship Award Review Committee; Stanford University
School of Medicine
INTERNATIONAL
2001
Invited Nominator Nobel Prize for Physiology or Medicine
2005
Peer Reviewer. The Sir Jules Thorn Award for Biomedical Research
London
INVITED SEMINARS AND ADDRESSES
1978
Departmental Seminar, Department of Physiology, Yale University
School of Medicine, New Haven, Connecticut.
 Departmental Seminar, Department of Neurobiology, Harvard Medical
School, Boston, Massachusetts.
Departmental Seminar, Physiological Laboratory, Rockefeller
University, New York.
Departmental Seminar, Department of Anatomy-Physiology, University of
California, Berkeley.
Society of General Physiologists, 32nd Annual Meeting, Woods Hole,
Massachusetts.
1979
International Symposium on Calcium Antagonists, Scottsdale, Arizona.
American Heart Association, Annual Scientific Sessions, Anaheim,
California.
Departmental Seminar, Department of Pharmacology, University of
California, San Francisco.
Seminar Speaker, Palo Alto Medical Foundation.
Biophysical Society, 23rd Annual Meeting, Atlanta, Georgia.
1980
Departmental Seminar, Cardiology Division, Harvard Medical School.
Departmental Seminar, Cardiology Division, Albert Einstein College of
Medicine, Bronx, New York.
Departmental Seminar, Cardiology Division, University of Chicago School
of Medicine.
Departmental Seminar, Department of Neurobiology, Stanford
University School of Medicine.
1981
International Symposium on Cardiovascular Diseases and Calcium
Antagonists, Ixtapa, Mexico.
Departmental Seminar, Department of Neurology, Stanford University
School of Medicine.
Invited Speaker, Bay Area Electrophysiology Society, San Francisco.
Biophysical Society, 25th Annual Meeting, Denver, Colorado.
1982
Departmental Seminar, Department of Pharmacology, Columbia
College of Physicians and Surgeons, New York.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
6
Society of General Physiologists, 36th Annual Meeting, Woods Hole,
Massachusetts.
American College of Cardiology Annual Scientific Sessions, Atlanta,
Georgia.
American Heart Association, Annual Scientific Sessions, Dallas.
1983
Departmental Seminar, Department of Anatomy, Emory University,
Atlanta, Georgia.
Departmental Seminar, Department of Pharmacology, Emory
University.
Departmental Seminar, Department of Pharmacology, University of
California, San Francisco.
Seminar Speaker, Palo Alto Medical Foundation.
Visiting Professor Lecture, Kaiser Santa Clara Medical Center.
American Section of the International Society for Heart Research.
Annual Meeting, Hilton Head, South Carolina.
1984
Society of General Physiologists 38th Annual Meeting, Woods Hole,
Massachusetts.
American Heart Association Annual Scientific Session, Miami, Florida.
Cardiology Division Seminar, University of California, San Francisco.
1985
International Symposium on Membranes and Muscle, Invited Lecturer
Capetown, South Africa.
Department of Medicine Faculty Research Conference, Stanford
University.
Society of General Physiologists 39th Annual Meeting, Woods Hole,
Massachusetts.
Departmental Lecture, Department of Cell Biology, Stanford University
School of Medicine.
Departmental Seminar, Department of Medicine, University of
Oklahoma, School of Medicine, Oklahoma City, Oklahoma.
1986
Invited Presentation, Satellite Symposium on Cardiac Electrophysiology of the International Congress of Physiology, Banff, Canada.
Departmental Seminar, Department of Pharmacology, Vanderbilt
University, Nashville, Tennessee.
Departmental Seminar, Department of Pharmacology, Columbia College
of Physicians and Surgeons, New York.
Departmental Seminar, Department of Medicine, Johns Hopkins
University School of Medicine, Baltimore, Maryland.
Invited Lecturer, NIH Gerontology Research Center, Baltimore
American Heart Association, National Research Forum for Established
Investigators, Boston, Massachusetts.
American Heart Association Science Writer’s Forum, Los Angeles,
California.
American Heart Association, Annual Scientific Session, Dallas, Texas.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
7
Biophysical Society, 30th Annual Meeting, San Francisco, California
1987
Session Co-Chairman, Biophysical Society, 31st Annual Meeting, New
Orleans, Louisiana.
Session Co-Chairman, American College of Cardiology, Annual Scientific
Sessions, New Orleans, Louisiana.
Seminar Speaker, Palo Alto Medical Foundation.
Departmental Seminar, Cardiology Division, University of Utah School of
Medicine.
Departmental Seminar, Department of Physiology-Anatomy, University of
California, Berkeley.
Postgraduate Seminar Speaker, American Heart Association, Annual
Scientific Sessions, Anaheim, California.
Session Co-Chairman, American Heart Association, Annual Scientific
Sessions, Anaheim, California.
1988
Joint Departmental Seminar, Departments of Physiology and Medicine
(Cardiology), University of California, Los Angeles.
Session Co-Chairman, Western Society for Clinical Investigation, Carmel,
California.
Invited Lecturer, The Rappaport Symposium on Lethal Arrythmias
Resulting from Myocardial Ischemia and Infarction, Haifa, Israel.
Departmental Seminar, Department of Physiology, Albert Einstein College
of Medicine, Bronx, New York.
Invited National Lecturer, Canadian Cardiac Electrophysiology Society,
Algonquin Park, Ontario, Canada.
Joint Departmental Seminar, Departments of Physiology and Medicine,
University of Calgary, Alberta, Canada.
Joint Departmental Seminar, Divisions of Cardiology and
Cardiovascular Radiology, University of California School of Medicine,
San Francisco, California.
Biophysical Society Annual Meeting, Phoenix, Arizona
Session Co-Chair, American Heart Association Annual Scientific
Sessions, Washington, D.C.
Invited Speaker, Annual Meeting of the American Electrophysiological
Society, Washington, D.C.
Annual Meeting, Society of General Physiologists, Woods Hole,
Massachusetts.

1989
Cardiology Grand Rounds, Columbia College of Physicians and
Surgeons, New York.
Biophysical Society Annual Meeting, Cincinnati, Ohio.
Invited Speaker, Stanford-INSERM Joint Symposium on Vascular Biology.
Alliance Francaise de San Francisco, California.
Invited Speaker, International Society for Heart Research Satellite
Symposium, “Energetics and Myocardial Ionic Homeostasis,”
Baltimore, Maryland.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
8
Invited Speaker, Nuclear Magnetic Resonance Center, San Francisco.
Veterans Administration Medical Center, San Francisco, California.
Society of General Physiologists 42nd Annual Meeting, Woods Hole,
Massachusetts.
Cardiology Grand Rounds, Toronto General Hospital, Toronto, Canada.
Departmental Seminar, Cardiology Division, Northwestern University
Chicago, Illinois.
Moderator, Cardiovascular Conference on Calcium Homeostasis. 62nd
Annual Scientific Sessions. American Heart Association, New Orleans,
Louisiana.
1990
American Heart Association Research Symposium,
Princeton, New Jersey.
Featured Speaker, American Society for Clinical Investigation,
National Meeting, Washington, D.C.
Departmental Lecture, Cardiology Division, University of Rochester,
Rochester, New York.
American Heart Association 63rd Annual Scientific Sessions, Dallas, Texas.
Principal Lecturer, Cardiovascular Physiology Course, University of
California, Irvine, California.
1991
 Invited Speaker, Cardiology Division, University of Cincinnati Medical
School, Cincinnati, Ohio.
 Invited Speaker, International Society for Heart Research, Cincinnati, Ohio.
 Invited Speaker, North American Society for Pacing and Electrophysiology,
Washington, D.C.
 Session Co-Chairman. Cardiac Electrophysiology Society. Annual
Meeting. Anaheim, California.
 Cardiology Grand Rounds. Beth Israel Hospital, Boston, Massachusetts.
1992
 Session Co-Chairman, California Heart Association. Young Investigator’s
Conference, Asilomar, California.
 Invited Speaker, Gordon Conference on Bioelectrochemistry, Tilton,
New Hampshire.
 Visiting Professor, Santa Clara Valley Medical Center, San Jose,
California.
1993
 Session Co-Chair: The Biology of Diastole in Health and Disease, Palm
Springs, Florida
 Visiting Professor, Santa Clara Valley Medical Center, San Jose,
California.
1994
 Visiting Professor, Santa Clara Valley Medical Center, San Jose,
California.
1995
 Biophysical Society Annual Scientific Sessions, San Francisco, California.
 Society of General Physiologists, 49th Annual Meeting, Woods Hole, MA
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
9
 American Heart Association Annual Scientific Sessions, Anaheim, CA.
1996
• Invited Speaker, Cardiovascular Division, University of California at
San Francisco (UCSF).
1998
 Cardiology Grand Rounds, Seton Medical Center, San Francisco,
California.
 Biomedicine Annual Scientific Sessions, Washington, D.C.
 Fifty Second Annual Meeting of General Physiologists, Woods Hole, Mass.
 Invited Speaker, New Insights into Arrhythmogenesis and Use of T Wave
Alternans for Risk Assessment. Dallas, Texas.
1999
 Session Co-Chair; Biophysical Society Annual Scientific Sessions,
Baltimore,MD.
 Twentieth Annual Scientific Session, North American Society for Pacing and
Electrophysiology, Toronto, Canada.
 Invited Speaker, Dr. Percy Lavon Julian Centenary Celebration. Oak Park,
Illinois. Sponsored by American Chemical Society.
 Continuing Medical Education Series; Cowell Student Health Center; Stanford
University.
 American Heart Association; Annual Scientific Sessions, Atlanta, Georgia,
How - to - Session.
2000
 Session Co-Chair and Presenter; Biophysical Society Annual Scientific
Sessions, Baltimore, MD
 Invited Speaker, Community Hospital of Los Gatos; Continuing Medical
Education Program.
 Medical Grand Rounds, Department of Medicine, Stanford University School
Of Medicine.
 Electrophysiology Rounds, Cardiology Division, University of California
At San Francisco, School of Medicine.
2001
• Session Co-chair and Presenter; Biophysical Society Annual Scientific
Sessions, Boston, MA.
 Invited Speaker, Cardiology Division, University of North Carolina at Chapel
Hill
 Invited Speaker, XVII World Congress of the International Society for
Heart Research, Winnipeg, Canada
 Departmental Seminar, Cardiology Division, Albert Einstein College of
Medicine
 Divisional Seminar, Cardiac Electrophysiology, University of California
at San Francisco, School of Medicine
 American Heart Association; Annual Scientific Sessions, Anaheim, CA
2002
Invited Speaker, Educational Program, St. Jude Medical; Sylmar, CA
Departmental Seminar; Cardiology Division; UCLA School of Medicine
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
10
Symposium on Sudden Cardiac Death; The Chicago Medical School
Chicago, Ill.
2003
 Invited Poster, First Keystone Symposia on Molecular Pathology of Cardiac
Arrhythmias; Santa Fe, New Mexico
Session Co-Chair, North American Society for Pacing and Electrophysiology
Washington, DC
Invited Speaker, Gordon Research Conference on Arrhythmia Mechanisms;
Colby-Sawyer College, New London, New Hampshire
Moderator, Office Practice Seminar of the Vascular Biology Working Group,
San Francisco, CA
Invited Speaker, Department of Internal Medicine, National Cheng Kung
University Hospital, Tainan, Taiwan
Invited Speaker, Division of Cardiology, National Taiwan University Hospital
Taipei, Taiwan
Invited Speaker, Division of Cardiology, Kaohsiung Medical University,
Kaohsiung, Taiwan
2004
Moderator, Office Practice Seminar of the Vascular Biology Working Group;
Sacramento, CA
Session Co-Chair; Two Sessions; North American Society for Pacing and
Electrophysiology (Heart Rhythm Society); San Francisco, CA
Invited Speaker, 14th World Congress in Cardiac Electrophysiology and
Cardiac Techniques (CARDIOSTIM), Nice, France
Electrophysiology Rounds, Cardiology Divison, University of California at San
Francisco School of Medicine
2005
●Department of Medicine Resident Conference, USAF Hospital, Travis AFB
Sacramento, CA
BIOGRAPHICAL SKETCHES
Thursday’s Child; Story of a Juvenile Heart Transplant Patient; Victoria Poole,
Little Brown, Boston; 1981; pp 184-185.
Confronting the War Machine; Draft Resistance During the Vietnam War; Michael
S. Foley; University of North Carolina Press, Chapel Hill; 2003; pp. 200-201; also
198, 408, 410.
BIBLIOGRAPHY
Ph.D. Thesis
Clusin WT: Current and voltage clamp analysis of skate electroreceptor
epithelium. Department of Neuroscience. Sue Golding Graduate Division of
Medical Sciences of Yeshiva University, 1976.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
11
JOURNAL ARTICLES
Citation History Noted for all Articles Cited More Than 30 Times
1.
Clusin W, Giannitrapani D, Roccaforte P: A numerical approach to matching
amplification for the spectral analysis of recorded EEG. Electroencephalography
Clin Neurophysiol 1970;28:639-641.
2.
Clusin W, Spray DC, Bennett MVL: Activation of a voltage insensitive conductance by inward calcium current. Nature 1975;256:425-427.
Number of Citations: 56
3.
Clusin WT, Bennett MVL: Calcium-activated conductance in skate electroreceptors: Current clamp experiments. J Gen Physiol 1977;69:121-143.
Number of Citations: 47
4.
Clusin WT, Bennett MVL: Calcium-activated conductance in skate electroreceptors: Voltage clamp experiments. J Gen Physiol 1977;69:144-182.
Number of Citations: 64
5.
Clusin WT, Bennett MVL: Multiple roles of calcium in a sensory receptor.
Ann NY Acad Sci 1978;307:439-44.
5.
Clusin WT, Bennett MVL: The oscillatory responses of skate electroreceptors to
small voltage stimuli. J Gen Physiol 1979;73:685-702.
Number of Citations: 35
7.
Clusin WT, Bennett MVL: The ionic basis of oscillatory responses in skate
electroreceptors. J Gen Physiol 1979;73:703-725.
8.
Clusin WT: Correlation between relaxation and automaticity in embryonic heart
cell aggregates. Proc Natl Acad Sci 1980;77:679-683.
9.
Clusin WT: The mechanical activity of chick embryonic myocardial cell
aggregates. J Physiol (Lond) 1981;320:149-174.
Number of Citations: 43
10.
Clusin WT, Bristow MR, Baim DS, Schroeder JS, Jaillon P, Brett P, Harrison DC:
The effects of diltiazem and reduced serum ionized calcium on ischemic
ventricular fibrillation in the dog. Circ Res 1982;50:518-526.
Number of Citations: 104
William Thomas Clusin, M.D., Ph.D.
11.
Curriculum Vitae
12
Clusin WT, Bristow MR, Karagueuzian HS, Katzung BG, Schroeder JS: Do
calcium-dependent ionic currents mediate ischemic ventricular fibrillation? Am J
Cardiol 1982;49:606-612.
Number of Citations: 91
12.
13.
Mason JW, Swerdlow CD, Winkle RA, Griffin JC, Ross DL, Keefe DL, Clusin WT:
Programmed ventricular stimulation in predicting vulnerability to ventricular
arrhythmias and their response to antiarrhythmic therapy. Am Heart J
1982;102:633-639.
Echt DS, Berte LE, Clusin WT, Samuelsson RG, Harrison DC, Mason JW:
Prolongation of the human monophasic action potential by sotalol. Am J Cardiol
1982;50:1082-1086.
Number of Citations: 116
14.
Clusin WT, deLeon AC: Anti-fibrillatory action of diltiazem during global left
ventricular ischemia. American College of Cardiology Extended Learning
Multimedia Journal, 1982;Vol. 14, Tape 12, Side 2.
15.
Clusin WT: Caffeine induces a transient inward current in cultured cardiac cells.
Nature 1983;301:248-250.
Number of Citations: 83
16.
Clusin WT, Buchbinder M, Harrison DC: Calcium overload, “injury” current and
early ischemic cardiac arrhythmias — A direct connection. Lancet 1983;I:272-274.
Number of Citations: 91
17.
Clusin WT: Mechanism by which metabolic inhibitors depolarize cultured cardiac
cells. Proc Natl Acad Sci 1983;80:3865-3869.
18.
Gillis AM, Clusin WT, Mason JW: New horizons in antiarrhythmic therapy.
J Cardiovasc Med 1983;9:959-964.
Article partially reprinted in The Yearbook of Emergency Medicine. DK
Wagner, ed. 1985;130-131.
19.
Clusin WT, Fischmeister R, DeHaan RL: Time course and voltage-sensitivity of
the caffeine-induced current in small clusters of cultured cardiac cells. Am J
Physiol 1983;245:H528-532.
Number of Citations: 51
20.
Clusin WT, Buchbinder M, Bristow MR, Harrison DC: Evidence for the role of
calcium in the genesis of early ischemic cardiac arrhythmias. Perspectives in
Cardiovasc Res 1984;9:293-302.
William Thomas Clusin, M.D., Ph.D.
21.
Curriculum Vitae
13
Clusin WT, Buchbinder M, Ellis AK, Kernoff RS, Giacomini JC, Harrison DC:
Reduction of ischemic depolarization by the calcium channel blocker diltiazem:
Correlation with improvement of ventricular conduction and early arrhythmias in
the dog. Circ Res 1984;54:10-20.
Article partially reprinted in The Yearbook of Emergency Medicine. DK
Wagner, ed., pp. 130-131
Number of Citations: 73
22.
Gillis AM, Clusin WT: The role of beta adrenergic receptor antagonists in the
prevention of sudden cardiac death. Comprehensive Ther 1984;10:60-67.
23.
Mason JW, Swerdlow CD, Winkle RA, Ross L, Echt DS, Anderson KP, Mitchell LB,
Clusin WT: Ventricular tachycardia induction for drug selection: Experience with
311 patients. Perspectives in Cardiovasc Res 1984;10:229-239.
24.
Mead RH, Clusin WT: Origin of the background sodium current and effects of
sodium removal in cultured embryonic cardiac cells. Circ Res 1984;55:67-77.
25.
Clusin WT: Do caffeine and metabolic inhibitors increase free calcium in the
heart? — Interpretation of conflicting intracellular calcium measurements. J Mol
Cell Cardiol 1985;17:213-220.
Number of Citations: 30
26.
Mead RH, Clusin WT: Paradoxical electromechanical effect of lanthanum ions in
cardiac muscle cells. Biophys J 1985;48:695-700.
27.
Blake K, Smith NA, Clusin WT: Rate-dependence of ischemic myocardial
depolarization — Evidence for a novel membrane current. Cardiovasc Res
1986;20:557-562.
28.
Blake K, Clusin WT: Reduction of ischemic myocardial depolarization and
extracellular potassium accumulation by diltiazem. Eur J Pharmacol
1986;127:261-265.
29.
Lee H-C, Clusin WT: Na+/Ca++ exchange in cardiac myocytes: Effect of ouabain
on voltage dependence. Biophys J 1987;51:169-176.
30.
Lee H-C, Smith NA, Mohabir R, Clusin WT: Cytosolic calcium transients from the
beating mammalian heart. Proc Natl Acad Sci 1987;84:7793-7797.
Number of Citations: 135
31.
Lee H-C, Clusin WT: Cytosolic calcium staircase in cultured myocardial cells.
Circ Res 1987;61:934-939.
Number of Citations: 64
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
14
32.
Blake K, Clusin WT, Franz MR, Smith NA: Mechanism of depolarization in the
ischemic canine heart: Discrepancy between T-Q potentials and potassium
accumulation. J Physiol (Lond) 1988;397:307-330.
33.
Clusin WT: What is the solution to sudden cardiac death? Cardiovasc Drugs and
Ther 1987;1:335-342.
34.
Lee H-C, Mohabir R, Smith N, Franz MR, Clusin WT: Effect of ischemia on
calcium-dependent fluorescence transients in rabbit hearts containing Indo-1:
Correlation with monophasic action potentials and contraction. Circulation
1988;78:1047-1059.
Number of Citations: 225
35.
Lee H-C, Clusin WT: Effect of BAY K8644 on cytosolic calcium transients and
contraction in embryonic cardiac ventricular myocytes. Pflugers Archiv
1989;413:225-233.
36.
McDonald T, Courtney KR, Clusin WT: Use-dependent block of single sodium
channels by lidocaine in guinea pig ventricular myocytes. Biophys J
1989;55:1261-1266.
37.
Dennis SC, Coetzee WA, deJong JW, Clusin W, Opie LH: Effects of coronary
flow, pacing rate, isoprenaline and diltiazem on ischemic ventricular arrhythmias in
guinea pig hearts. J Pharm Exper Ther 1989;248: 372-377.
38.
Opie L, Clusin WT: Cellular mechanisms of cardiac arrhythmias. Ann Rev Med
1990;41: 231-238.
39.
Mohabir R, Clusin WT, Franz MR: In vivo electrophysiologic detection of
myocardial ischemia through monophasic action potential recording. Prog in
Cardiovasc Disease 1991;34:15-28.
40.
Chien WW, Mohabir R, Clusin WT: Effect of thrombin on calcium homeostasis in
chick embryonic heart cells: Receptor-operated calcium entry with IP3 and a
pertussis toxin-sensitive G protein as second messengers. J Clin Invest
1990;86:1436 -1443.
Number of Citations: 33
41.
Chien WW, Mohabir R, Newman D, Leung LLK, Clusin WT: Effect of platelet
release products on cytosolic calcium in cardiac myocytes. Biochem Biophys Res
Comm 1990;170:1121-1127.
42.
Mohabir R, Lee H, Kurz RW, Clusin WT: Effects of ischemia and hypercarbic
acidosis on calcium transients, contraction and pHi in perfused rabbit hearts
containing Indo-1 and BCECF. Circulation Research 1991;69:1525-1537.
Number of Citations: 72
William Thomas Clusin, M.D., Ph.D.
43.
Curriculum Vitae
15
Lauer MR, Gunn MD, Clusin WT: Endothelin activates voltage-dependent Ca++
current by a G-protein-dependent mechanism in cardiac myocytes. J Physiol
1992;448:729-747.
Number of Citations: 63
44.
Wu Y, Clusin WT: Calcium transient alternans in blood perfused ischemic hearts:
Observations with the fluorescent indicator Fura Red. Am J Physiol 1997;373:
H2161-H2169.
Number of Citations: 33
45.
Clusin WT, Anderson M: Calcium channel blockers: Current controversies and
basic mechanisms of action. Advances in Pharmacology 1999; 46:253-296.
46.
Qian YW, Clusin WT, Lin SF, Han J, Sung RJ: Spatial heterogeneity of calcium
transient alternans during the early phase of myocardial ischemia in the blood
perfused rabbit heart. Circulation 2001; 104: 2082-2087.
47.
Clusin WT: Calcium and cardiac arrhythmias – DAD’s, EAD’s and alternans.
Critical Reviews in Clinical Laboratory Sciences 2003; 40: 337-375.
48.
Qian Y-W, Sung RJ, Lin S-F, Province R, Clusin WT: Spatial heterogeneity of
action potential alternans in blood-perfused ischemic rabbit hearts. American J of
Physiology (Heart and Circulatory Physiology) 2003; 285: H2722-H2733 Published on Line, August 7.
BOOK CHAPTERS
1.
Clusin WT: A simple electric motor. In World Book Encyclopedia E: 1963;136136a.
2.
Bennett MVL, Clusin WT: Physiology of the ampulla of Lorenzini, the electroreceptor of Elasmobranchs. In Sensory Biology of Sharks, Skates and Rays.
E.S. Hodgson, ed., U.S. Department of Naval Research, Arlington, VA, 1978;483505.
3.
Bennett MVL, Clusin WT: Transduction by electroreceptors: Origins of sensitivity.
In Membrane Transduction Systems -- A Symposium. RA Cone and JE Dowling,
1979;91-116.
4.
Clusin WT: The role of intracellular calcium in alterations of cardiac excitation. In
Drug-Induced Heart Disease. MR Bristow, ed., Elsevier Press, Amsterdam,
1980;103-126.
5.
Clusin WT: Normal and abnormal automaticity of cultured embryonic cardiac
cells. In Cardiac Arrhythmias -- A Decade of Progress. DC Harrison, JW Mason,
HA Miller and RA Winkle, eds., G.K. Hall, Boston MA. 1981;69-85.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
16
6.
Clusin WT, Buchbinder M, Mead RH: The potentially direct role of intracellular
calcium overload in the electrophysiology of cardiac ischemia. In Cardiac
Antagonists -- Mechanisms of Actions on Cardiac Muscle and Vascular Smooth
Muscle. N Sperelakis and B. Caulfield, eds., Martinus Nijhoff, Boston, MA.
1984;203-217.
7.
Clusin WT, Blake K, Smith NA, Buchbinder M.: Mechanism of cellular
depolarization in the acutely ischemic heart. In Membranes and Muscle. MC
Berman, W Gevers, LH Opie, eds., IRL Press, Oxford, 1985;291-307.
8.
Clusin WT: Role of calcium-activated ion currents in the heart. In Cardiac
Physiology and Pathophysiology. N Sperelakis, ed., 2nd ed., Martinus Nijhoff,
Boston, MA. 1988;95-114.
9.
Clusin WT, Mohabir R, Lee H: Role of cytosolic calcium in the normal and
ischemic heart: Potential insights from the second generation indicator, Indo-1. In
Lethal Arrhythmias of Myocardial Ischemia and Infarction. MR Rosen and Y Palti,
eds. 1988;13-29,.
10.
Mohabir R, Clusin WT, Lee H: Intracellular calcium alternans and the genesis of
ischemic ventricular fibrillation. In Cardiac Electrophysiology -- From Cell to
Bedside. DP Zipes and J Jalife, eds., 2nd ed. WB Saunders Co., 1990;448-456.
11.
Opie LH, Coetzee WA, Clusin WT: Calcium ions and ventricular arrhythmias. In:
“Myocardial Response to Injury”, edited by J. R. Parratt. MacMillen Press,
1992;48-66.
12.
Clusin WT: The role of cytosolic calcium in electrical alternans: Correlation of
electrical, mechanical and calcium fluorescence signals. In: Monophasic Action
Potentials: Bridging Cell and Bedside M.R. Franz, ed Futura, 1999;209-225.
13.
Clusin WT: Calcium signalling during acute myocardial ischemia: New insights
from optical mapping techniques. In: Pathophysiology of Cardiovascular Disease
edited by N.S. Dhalla, H. Rupp, A. Angel and G.N. Pierce. Kluwer, Boston 239255; 2004.
PUBLISHED ABSTRACTS
1.
Clusin WT, Giannitrapani D: EEG and visual performance. Electroencephalography Clin Neurophysiol 1969;27:707.
2.
Clusin WT, Giannitrapani D: EEG and short-term digit retention. Electroencephalography Clin Neurophysiol 1970;28:418.
3.
Clusin WT, Bennett MVL: Calcium electrogenesis in skate electroreceptors.
Biological Bulletin 1973;145:429.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
17
4.
Clusin WT, Spray DC, Bennett MVL: Cytoplasmic calcium initiates the outward
current in skate electroreceptors. Proceedings of the Jerusalem Symposium on
Synaptic Transmission of the XXVI International Congress of Physiology 1974;13.
5.
Clusin WT, Bennett MVL: Negative slope resistance in skate electroreceptors.
Federation Proceedings 1974;33:1471.
6.
Clusin WT, Spray DC, Bennett MVL: Ionic currents in skate electroreceptors.
Biological Bulletin 1974;147:472.
7.
Bennett MVL, Clusin WT: Transduction by electroreceptors. J Gen Physiol
1977;70:19a.
8.
Clusin WT: Contraction signals during diastolic depolarization in beating
embryonic heart cell aggregates. J Gen Physiol 1978;72:3-4a.
9.
Clusin WT: The role of intracellular calcium in the automaticity of embryonic heart
cell aggregates. Biophys J 1979;25: 80a.
10.
Clusin WT: Mechanical properties of chick embryonic heart cell aggregates.
Circulation 1979;60 II:138.
11.
Clusin WT: Overdrive pacing alters relaxation in chick embryonic heart cell
aggregates. Circulation 1979:60 II:138.
12.
Clusin WT, Griffin J, Profitt C, Harrison DC: Production of narrow, complex
ventricular tachyarrhythmias by QRS-triggered pacing during coronary occlusion.
Clin Res 1979;27(1):2A,.
13.
Clusin WT: Evidence for a role of sodium-calcium exchange in the regulation of
contractility in chick embryonic myocardial cell aggregates. Biophys J
1981;33:10a.
14.
Clusin WT, Bristow MR, Jaillon P, Brett P, Schroeder JS: Diltiazem and re-duced
serum-ionized calcium both retard ventricular fibrillation following coronary ligation.
Clin Research 1981;29 (2):181A.
15.
Echt DS, Berte LE, Clusin WT, Samuelsson RG, Harrison DC, Mason JW:
Monophasic action potential effects of sotalol compared to propranolol. Circulation
1981;63 II:136.
16.
Clusin WT, Baim DS, Bristow MR, Schroeder JS, Harrison DC: Antifibrillatory
action of diltiazem during global left ventricular ischemia. Am J Cardiol 1982;49:
913.
17.
Clusin WT: Substances releasing intracellular Ca++ ions induce inward current in
cultured cardiac cells. J Gen Physiol 1982;80:13a.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
18
18.
Clusin WT: Metabolic inhibitors induce calcium-dependent inward current in
cultured cardiac cells. Circulation 1982;66 II:15.
19.
Clusin WT: Caffeine induces a transient inward current in cultured cardiac cells.
Circulation 1982;66 II:15.
20.
Harrison DC, Bristow MR, Clusin WT: Calcium in acute myocardial ischemia.
Proc of the 13th Biennial Congress of the Southern African Cardiac Society, 1982.
21.
Mead RH, Clusin WT: Effects of Na removal on “background” current in cultured
cardiac cells. Circulation 1983;68 III:97.
22.
Clusin WT, Buchbinder M, Ellis AK, Kernoff RS, Giacomini JC, Harrison DC:
Reduction of ischemic depolarization by diltiazem: A flow-independent effect.
Circulation 1983;68 III:883.
23.
Mead RH, Clusin WT: Paradoxical effect of La+++ ions on the response of
cultured cardiac cells to sodium withdrawal. J Gen Physiol 1984;84:83a.
24.
Clusin WT, Opie LH, Thandroyen FT, Owen P: Drastic reduction of cardiac work
fails to mimic the antifibrillatory effect of low calcium. Circulation 1984;70 II:346.
25.
Blake K, Clusin WT: Reduction of ischemic myocardial K+ efflux by diltiazem —
Correlation with improvement of “injury” potentials. Circulation 1984;70 II:501.
26.
Blake K, Smith NA, Clusin WT: Ionic basis of cellular depolarization in the
ischemic heart. J Gen Physiol 1985;86:39a.
27.
Lee H-C, Clusin WT: Microfluorometric Ca++ measurements in Quin 2 loaded
cardiac cells: Effects of zero sodium and caffeine. Biophys J 1986;49:52a.
28.
Lee H, Clusin WT: Intracellular Ca++ transients in chick embryonic heart cells —
Correlation with mechanical activity. Proceedings of the Banff Satellite
Symposium on Cardiac Muscle of the XXXII International Congress of Physiology,
1986.
29.
Lee H-C, Clusin WT: Intracellular Ca++ transients in chick embryonic heart cells
— Correlation with mechanical activity. Circulation 1986;74:II-169a.
30.
Blake K, Smith NA, Franz MR, Clusin WT: Mechanism of depolarization in the
acutely ischemic canine heart. Circulation 1986;74:II-117a.
31.
Lee H, Clusin WT: Mechanism of cardiac staircase demonstrated by Indo-1
microfluorometry. Biophys J 1987;51:411.
32.
Lee H, Clusin WT: Factors governing the duration of cytosolic calcium transients
and contraction in embryonic myocardial cell aggregates. Circulation 1987;76:IV471.
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
19
33.
Lee H, Mohabir R, Clusin WT: Cytosolic calcium transients from the intact
mammalian heart. Biophys J 1988;52:641a.
34.
Mohabir R, Lee H, Clusin WT: Cytosolic calcium transients from isolated rabbit
hearts. Proc Can Fed Biol Sci, 1988;p.132.
35.
Mohabir R, Lee H, Clusin WT: Mechanism of the early increase in [Ca++]i during
cardiac ischemia: Does ATP secretion play an role? J Gen Physiol 1988;92:48a49a.
36.
Mohabir R, Lee H, Clusin WT: Does extracurricular ATP mediate the early effect
of ischemia on cytosolic calcium transients in the intact heart? Circulation
1988;78 II:461.
37.
Lee H, Mohabir R, Franz MR, Clusin WT: Alternans behavior of calcium
transients, action potentials and contraction in the acutely ischemic rabbit heart.
Circulation 1988;78 II:462.
38.
Mohabir R, Lee H-C, Clusin WT: Simultaneous recordings of [Ca++]i and pHi in
perfused rabbit hearts containing Indo-1 and BCECF. Biophys J 1989;55:485a.
39.
Chien W, Mohabir R, Leung LL, Clusin WT: Effects of thrombin on calcium
transport in cultured cardiac myocytes. J Gen Physiol 1989;94:22a.
40.
Lauer MR, Gunn MD, Clusin WT: Effect of endothelin on cytosolic calcium and
membrane current in single ventricular myocytes. Circulation 1989;80:94.
41.
Chien W, Mohabir R, Leung L, Clusin WT: Effects of platelet release products on
cytosolic calcium in cardiac myocytes. Circulation 1989;80:148.
42.
Chien W, Mohabir R, Clusin WT: Thrombin promotes calcium entry and release
in cultured cardiac myocytes. Circulation 1989;80:196.
43.
Mohabir R, Kurz RW, Clusin WT: Calibration of cytosolic calcium transients
during global ischemia in the rabbit heart. Circulation 1990,82:(III):570.
44.
Lauer MR, Clusin WT: Endothelin increases cytosolic Ca++ and enhances cardiac
myocyte Ca++ current by a G-protein-dependent mechanism.
Biophys.J . 1991;59:552a.
45.
Lauer MR, Clusin WT: Effect of endothelin on cardiac Ca++ current: Further
studies of the subcellular mechanism. Circulation 1991;84.
46.
Wu YM, Clusin WT: Fura-Red: A superior indicator for recording calcium
transients in perfused hearts. Biophys.J. 1995,68:A419.
47.
Wu Y-M, Clusin WT: Greater incidence of calcium transient alternans in blood
perfused ischemic rabbit hearts. Circulation 1995,92:I-1220 (abstr.).
William Thomas Clusin, M.D., Ph.D.
Curriculum Vitae
20
48.
Wu YM, Clusin WT: Effects of Ischemia on Cytosolic Calcium Transients in Blood
Perfused Rabbit Hearts Loaded with Fura Red. J. Gen. Physiol. 1995,106:19a
(abstr.).
49.
Clusin WT, Vriens P, and Qian YW. Cytosolic calcium transients from in vivo
porcine hearts. J Investigative Med 1998;46:193a (abstr.).
50.
Clusin WT, Vriens P, Qian YW and Robbins RC: Calcium transients from the left
ventricular surface of the heart in open chest pigs. J. Gen. Physiol. 1998;112:16a
(abstr.).
51.
Clusin WT, Qian YW, Han J and Lin SF: Optical imaging of [Ca]i transients and
[Ca++]i transient alternans in normal and ischemic rabbit hearts. Biophysical J ,
1999;76:A28.
52.
Clusin WT, Han J and Qian YW: Simultaneous recordings of calcium transients
and action potentials from small regions of the perfused rabbit heart. Pace
1999;22:834,.
53.
Qian YW, Han J, Lin S-F, Clusin WT: Local heterogeneity of calcium transient
Alternans in the ischemic rabbit heart. Circulation 1999;100:I –50.
54
Qian YW, Lin SF, Han J, Sung RJ, and Clusin WT: Quantitative maps of calcium
transient alternans in the ischemic rabbit heart. Biophysical J 2000;78:16A (abstr).
55.
Qian YW, Lin SF, Sung RJ, Clusin WT: Spatial Heterogeneity of action potential
alternans in blood perfused ischemic rabbit hearts. Biophysical J. 2001;80:643a.
56.
Qian YW, Clusin WT, Sung RJ, Lin SF, Province R: Comparison of action
potential and calcium transient alternans maps in bood perfused ischemic rabbit
hearts. Circulation 2001; 104: 516a.
Rev Jan 2005